Human Fibroblast-Like Synoviocytes (HFLS) are found in the joints, where they produce synovial fluid glycoproteins essential for lubrication. CAI's normal HFLS are derived from joints of healthy donors.  Proinflammatory cytokines like GM-CSF induce HFLS proliferation and stimulate production of erosive enzymes that degrade subchondral bone and articular cartilage.  We also isolate HFLS from those suffering from Rheumatoid and Osteoarthritis.  See all of our arthritis disease models.