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IL-35: Human Interleukin-35

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Description

BACKGROUND  Interleukin 35 (IL-35) is a member of the IL-12 cytokine family and is produced by regulatory T cells (Tregs).  IL-35 is a heterodimeric cytokine that is comprised of the interleukin 12 subunit P35 (IL-12a) and the interleukin 27 subunit beta (IL-27b) chains.  IL-35 binds the IL-12Rbeta2/gp130 hetero- and homodimers to activate STAT1 and STAT4 signaling.  IL-35 functions as a suppressor of immune cell inflammatory responses.

 

Products are for research use only. They are not intended for human, animal, or diagnostic applications.

Resources

Product Sheet RP1049

Format: PDF

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