Anti-AQP1: Polyclonal Aquaporin 1 Antibody

AQP1 is the predominant and least specialized subtype. It plays a major role in constitutive water transport through the membranes of several cell types including endothelial cells, red blood cells, and renal proximal tubule cells. It has been shown that AQP1 may also function as a cyclic nucleotide-gated cation channel that is activated mainly by cGMP and indirectly also by cAMP. It was reported that AQP-1 transports small gas molecules such as carbon dioxide and NO in cells.² Moreover, ion currents of native aquaporins were confirmed in choroid plexus epithelium and shown to modulate fluid transport of those cells. Furtheremore, it was shown that PKC positively regulates both water permeability and ionic conductance of AQP1 channels.³