Anti-GSTM1: Mouse GSTM1 Antibody
Mouse GSTM1 Antibody: Mouse GSTM1 Antibody
Size: 100 ul
Price: $457.00
Description
GSTM1 is polymorphic in humans. Approximately 50% of individuals in most human populations completely lack the gene and thus the activity of GSTM1. The deletion of the GSTM1 gene seems to be caused by an unequal crossing over event between sequences about 5 kb downstream from GSTM2 and GSTM1, which results in the deletion of the entire GSTM1 gene. The GSTM1 copy number variation (CNV) is in a sense unique. It was shown recently that that ∼60–70% expression from one allele of GSTM1 could suffice for protection against breast cancer; null activity and over activity of GSTM1 are both disadvantageous. These results indicate a U-shaped association of GSTM1 with breast cancer.2
2. Yu, K.-D. et al: FASEB J. 23:2274-87, 2009
Details
Cat.No.: | CP10437 |
Antigen: | Recombinant human GSTM1 fragments expressed in E. coli. |
Isotype: | Mouse IgG1 |
Species & predicted species cross- reactivity ( ): | Human, Mouse, Rat |
Applications & Suggested starting dilutions:* | WB 1:1000 IP n/d IHC 1:50 – 1:200 ICC n/d FACS 1:50 – 1:200 |
Predicted Molecular Weight of protein: | 28 kDa |
Specificity/Sensitivity: | Detects GSTM1 proteins in various cell lysate. |
Storage: | Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles. |
*Optimal working dilutions must be determined by end user.