Anti-HSP60: Mouse HSP60 Antibody

Recently, the presence of HSP60 outside the mitochondria and outside the cell, e.g. in circulating blood, has been reported.² This extra-mitochondrial HSP60 in the heart has key anti-apoptotic functions. Extra-mitochondrial HSP60 complexes with both bax and bak, but not with bcl-2. Reduction in HSP60 is sufficient to precipitate apoptosis. However, HSP60 may participate in triggering apoptosis in other cells. In addition, HSP60 has been found on the cell-membrane’s outer surface in both normal and tumor cells. It has been implicated in transmembrane transport and signaling, activation and maturation of dendritic cells with generation of antitumor T-cell responses. Microbial HSP60 constitutes a major antigen recognized by the immune system during bacterial infections. Owing to the strong homology between microbial and human HSP60 an immune reaction against infectious microbes may lead to a cross-reactive autoimmune response against the native human HSP60.³