Anti-KLHL22: Mouse KLHL22 Antibody
Mouse KLHL22 Antibody: Mouse KLHL22 Antibody
Size: 100 ul
Price: $413.00
Description
The actin-binding protein Kelch-like 22 (KLHL22) a 634 amino acid protein that belongs to the evolutionarily-conserved Kelch protein super-family. Human KLHL22 protein contains six kelch repeats and one BTB (POZ) domain. BTB/POZ domain are involved in protein-protein interactions. There are two isoforms of KLHL22 that are produced as a result of alternative splicing events. It was shown that KLHL22 plays important role in regulation of mitosis. KLHL22 and KLH21 are associated with Cullin3, a E3 ubiqutin ligase. Cul3 (Cullin3) assembles with BTB domain adaptors, which bind to specific substrates via distinct protein interaction domains.2
2. Maerki, S. et al: J. Cell Biol. 187:791-800, 2009
Details
Cat.No.: | CP10270 |
Antigen: | Purified recombinant human KLHL22 fragments expressed in E. coli. |
Isotype: | Mouse IgG1 |
Species & predicted species cross- reactivity ( ): | Human, Mouse, Rat |
Applications & Suggested starting dilutions:* | WB 1:1000 IP n/d IHC n/d ICC 1:50 – 1:200 FACS n/d |
Predicted Molecular Weight of protein: | 72 kDa |
Specificity/Sensitivity: | Detects KLHL22 proteins without cross-reactivity with other related proteins. |
Storage: | Store at -20°C, 4°C for frequent use. Avoid repeated freeze-thaw cycles. |
*Optimal working dilutions must be determined by end user.