Anti-MPO: Rabbit Myeloperoxidase Antibody
Rabbit Myeloperoxidase Antibody: Rabbit Myeloperoxidase Antibody
Size: 100 ul
Price: $375.00
Description
MPO activity measurement is used as an index of inflammation, because the MPO levels are increased in inflammatory tissue largely secondary to PMN extravasation. MPO is also present in human atherosclerotic lesions, and plasma MPO activity may be an excellent marker of acute coronary syndromes. The MPO-induced catalysis of low-density lipoprotein oxidation converts low-density lipoprotein into its high uptake form and thus contributes to the formation of foam cells and cholesterol deposition in the vessel wall. MPO activates the formation of protein nitrotyrosine (NO2Tyr), a characteristic of acute and chronic inflammation. In addition, The MPO was localized with fibronectin in the extracellular matrix and induced tissue remodeling by nitration of matrix proteins.3
2. Lau, D. et al: Proc. Natl. Acad. Sci. USA 102:431-6, 2005
3. Tiruppathi, C. et al: Proc. Natl. Acad. Sci. USA 101:7699-704, 2004Ā
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Details
| Cat.No.: | CA1054 |
| Antigen: | Short peptide from human MPO sequence. |
| Isotype: | Rabbit IgG |
| Species & predicted species cross- reactivity ( ): | Human, Rat |
| Applications & Suggested starting dilutions:* | WBĀ Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 1:1000 IPĀ Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā n/d IHCĀ Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā 1:50 – 1:200 ICCĀ Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā n/d FACSĀ Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā Ā n/d |
| Predicted Molecular Weight of protein: | 150 kDa |
| Specificity/Sensitivity: | Detects endogenous levels of MPO proteins without cross-reactivity with other related proteins. |
| Storage: | Store at -20Ā°C, 4Ā°C for frequent use. Avoid repeated freeze-thaw cycles. |
*Optimal working dilutions must be determined by end user.