Anti-NOS2: Rabbit NOS2 Antibody

Inducible NOS2/iNOS is an inflammation-responsive enzyme that is upregulated in acute and chronic inflammation as part of host defense and the wound-healing process. Upregulation of this enzyme leads to increased NO production, by which it affects the redox state of cells. Aberrant expression of NOS2/iNOS has been observed in many types of solid tumors, including breast and colon cancer, and also in melanoma. NO can both cause DNA damage and protect from cytotoxicity and either inhibit or stimulate cell proliferation and migration as well as apoptosis.² The effect of NO will be dependent on the microenvironment, including tissue oxygen tension and local superoxide concentrations. Additionally, it was shown that NOS2/iNOS expression correlates with increased Akt phosphorylation in breast tumors and that NO induces Akt phosphorylation and activation of the oncogenic Akt pathway in breast cancer cells in culture. There is a relationship between NOS2/iNOS expression, increased NO production, and the induction of a basal-like transcription pattern and poor prognosis in ER-negative breast tumors.³