MICA ELISA Kit, Human
Human MICA ELISA Kit: Human MHC Class I Polypeptide-Related Sequence A ELISA Kit
Size: 96 Wells
Price: $581.00
Description
MICA displays the greatest degree of polymorphism. MICA alleles can be divided into two large groups with the polymorphisms found in alpha3 domains. This division could be explained by a possible polyphyletic origin that is in line with recent findings from evolutionary, population and functional studies of this gene. MICA polymorphisms are associated with a number of diseases related to NK activity, such as viral infection, cancer and allograft rejection or graft-versus-host disease (GVHD). The mechanisms underlying these associations include NK cell-mediated cytotoxicity and MICA shedding to produce immunosuppressive soluble MICA particles. The MICA-induced humoral response has attracted interest recently because of its possible role in graft rejection in solid organ transplantation.3
2. Stephens, H.A.F.: Trends Immunol. 22:378-85, 2001
3. Bahram, S.: Adv. Immunol. 76:1-60, 2001Â
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Details
Cat.No.: | CL0812 |
Target Protein Species: | Human |
Range: | 62.5pg/ml – 4000 pg/ml |
Specificity: | No detectable cross-reactivity with other cytokines |
Storage: | Store at 4°C. Use within 6 months. |