TNFα: Mouse Tumor Necrosis Factor-alpha

BACKGROUND Tumor Necrosis Factor alpha (TNF?) is an inflammatory cytokine secreted by macrophages, monocytes, neutrophils, T-cells, NK-cells following their stimulation by bacterial LPS. TNF-? activates signals through two receptors, TNF-R1, which is expressed on most cell types, and TNF-R2, which is expressed mainly on immune cells. TNF-? can have many functions including, to stimulate of phagocytosis in macrophages, to chemoattract neutrophils, to increase insulin resistance and to induce fever. Recombinant mouse TNF-? is a non-glycosylated protein, containing 156 amino acids and having a molecular mass of 17.3 kDa. Products are for research use only. They are not intended for human, animal, or diagnostic applications.