BMP-5 ELISA Kit, human

BMP-5, one of the more prominently expressed BMPs in the nervous system, has been detected in multiple regions of the nervous system throughout development and into adulthood. BMP-5 belongs to the 60A subgroup of BMPs, which also includes BMP-6/Vgr-1, BMP-7/OP-1, BMP-8a/OP-2, BMP-8b and Drosophila 60A. Other members of the 60A subgroup have been shown to modulate neuronal morphogenesis through selective effects on dendrites. Thus, BMPs 6, 7, and 60A stimulate dendritic growth in cultured sympathetic neurons derived from either perinatal or adult ganglia in the absence of effects on cell survival or axonal growth. BMP-7 has also been shown to enhance dendritic growth in hippocampal, cortical and spinal motor neurons. A role for BMP-5 in dorsal forebrain patterning has been proposed based on its expression in the dorsal midline of the developing forebrain and observations that ectopic expression of BMP-5 in the developing neural tube of chicks markedly downregulates ventral markers while maintaining dorsal markers.³ In addition, through phenotypes of short-ear (se) mice, which have BMP-5 mutations, a role for BMP-5 in some specific aspects of skeletogenesis and cartilage growth is known. It was demonstrated that BMP-5 is normally an important regulator of chondrocyte proliferation and differentiation.⁴ Moreover, BMP-5 has been shown to be essential for nephrogenesis.