Cardiotrophin-1 ELISA Kit, Human

CT-1 mRNA expression has been detected at high levels in heart, skeletal muscle, prostate, ovaries, and liver, as well as fetal heart, lung, and kidney, and in lower amounts in other tissues. It has been reported that CT-1 gene expression is increased in ventricular myocardium after myocardial infarction (MI) and in hypertensive rats. And cardiac CT-1 gene expression is activated in both canine atrial and ventricular myocardium in experimental congestive heart failure. Thus, CT-1 may have an important role in the development of cardiac hypertrophy and heart failure. In addition, Adipose tissue has emerged as a key secretory organ, with the ability to secrete different adipokines, including IL-6. It has been shown that adipocytes express gp130 and LIFR and respond to IL-6 family cytokines, including CT-1. Moreover, CT-1 expression progressively increased, along with differentiation time from preadipocyte to mature adipocyte in 3T3-L1 cells. CT-1 expression was enhanced by glucose in a dose-dependent manner in these cells.³ Furthermore, CT-1 appears to be a mediator of impaired insulin sensitivity, as chronic administration of CT-1 to 3T3-L1 adipocytes resulted in a decrease in insulin-stimulated glucose uptake.⁴