Crohn's Disease Cellular Disease Models

Crohn’s Disease (CD) is an inflammatory bowel disease (IBD) that causes chronic inflammation of the gastrointestinal tract. While Crohn’s Disease most commonly affects the ileum and colon, the disease can affect any part of the GI tract from the mouth to the anus. An estimated 3 million Americans are affected by IBD. While genetics (positive family history for IBD is the greatest known risk factor) and immune response play a role in the disease, the cause of the disorder is unknown. And while standard treatment (anti-inflammatory steroids and immunosuppressants) can slow progression of disease, there is no known cure.

To better understand the disease and how to treat it, Cell Applications offers researchers access to an unprecedented biobank of Epithelial Cells from Crohn’s Disease cases. The Cell Applications biobank includes a diverse cohort of disease age, location, and behavior. Sample locations include colon (Cn), ileum (Il), Rectum (Re). CD cells are categorized as untreated (naive) and Treated Crohn’s Disease. Generally, naive cells are from Crohn’s Disease cases exhibiting non-stricturing, non-penetrating behavior (B1), while stricturing (B2) and penetrating (B3) CD patients have sought treatment.

For your convenience, the Epithelial Cell Total Kit includes all the reagents you need for gastrointestinal epithelial cell culture. Along with a cryovial of 500,000 diseased epithelial cells, the Total Kit includes optimized cell culture medium, thawing medium, and coating solution. Cells can be cultured up to 7 days. Cells cannot be passaged and should be plated directly into the experimental system.

Learn more about:

IBD Gastrointestinal Epithelial cells
Non-diseased Gastrointestinal Epithelial Cells