Metabolically active brown adipose tissue is limited in adults.
Studying human brown fat was nearly impossible.
Until now…
Brown Adipose Tissue (BAT) performs thermogenesis, clearing circulating glucose and fatty acids as it converts them into heat through mitochondrial oxidation.
Brown fat also influences systemic metabolism through endocrine factors known as batokines.
Because of these properties, BAT has become a key target in obesity, diabetes, and metabolic disease research.
CELL APPLICATIONS is the first to offer human brown preadipocytes (i-HBrPAd) derived from pluripotent stem cells, also known as iPSCs.
These cells differentiate in 14 days and remain viable and metabolically responsive for up to two weeks.
Differentiated cells exhibit multilocular lipid droplets characteristic of brown adipocytes, visible by Oil Red O staining.
Over 95% of cells express PRDM16, a master regulator of brown fat lineage identity.
Researchers now have access to human thermogenic biology, enabling the next phase of obesity and diabetes research.
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