In July 2025, at a collaborative FDA & NIH Workshop on Reducing Animal Testing, the NIH announced:
“All new NIH Funding Opportunities moving forward should incorporate language on consideration of New Approach Methodologies (NAMs).
NIH will no longer seek proposals exclusively for animal models.”
See the new video:
New Approach Methodologies (NAMs)
in vitro
in silico
in chemico
Dr. Nicole Kleinstreuer, NIH Deputy Director for Program Coordination, Planning, and Strategic Initiatives indicated, “…the NIH is shifting investment to prioritize technologies that are rooted in human biology…” and these include primary cells, organ-on-a-chip, and organoids.
“NIH’s objective is to invest in technologies that will really allow a reduction in reliance on animal models and offer more predictive, reproducible, and ethical science.”
Starting in 2026, grants that were authored and submitted after the NIH announcement will be funded and many will need primary cells for “organ-on-a-chip” devices and organoids.
Cell Applications is your trusted source for in vitro New Approach Methodologies (NAMs) materials:
- Primary Cells for organ-on-a-chip
- Organoids
Organoids are 3D cell structures that mimic key features of human tissues in vitro and Cell Applications offers an array of organoid models including Human Hepatocytes (i-HH) with active liver functions and Alveolar Epithelial cells (AEC2 / i-HAEpC2) that express the COVID-19 receptor, ACE2
Cell Applications not only provides the cells, but also the high-performance media, supplements, and reagents required for this next generation of research.
Cell Applications is the only manufacturer of convenient, all-in-one growth media.
Cell Applications’ media outperforms other commercial media.*
*Leopold, B.; Strutz, J.; Weiß, E. (21 September 2019). “Outgrowth, proliferation, viability, angiogenesis and phenotype of primary human endothelial cells in different purchasable endothelial culture media: feed wisely”. Histochemistry and Cell Biology. 152 (5): 377–390. doi:10.1007/s00418-019-01815-2. PMC 6842357. PMID 31541300.
Visit www.cellapplications.com for the primary cells, media, and reagents to successfully transition from animal testing to organoid and organ-on-a-chip research.
Questions? Contact us today 1-800-645-0848
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