Bovine Coronary Artery Endothelial Cells: BCAEC. Isolated from blood vessel tissue.
Bovine Coronary Artery Endothelial Cells: BCAEC
Description
Bovine Coronary Artery Endothelial Cells (BCAEC) from CAI have been used to demonstrate that stress hormone cortisol inhibits NO synthase and Ca2+ mobilization, leading to decreased NO release by endothelial cells, resulting in increased arterial contraction and decreased blood flow. A Similar action mechanism was determined for cocaine effects on arteries. Additionally, it was found that cocaine-induced apoptosis of endothelial cells is mediated by attenuation of NO production, down-regulation of Bcl-2 and translocation of Bac to the mitochondria, followed by release of cytochrome c and activation of caspase 9 and caspase 3. BCAEC were also used to determine diabetes-related vascular dysfunction. Others employed the cells to evaluate novel mesh-like materials for their suitability for biomedical applications.
Details
| Tissue | Normal healthy bovine coronary artery | |
|---|---|---|
| QC | No bacteria, yeast, fungi, mycoplasma | |
| Character | DiI-Ac-LDL uptake: Positive | |
| Bioassay | Attach, spread, proliferate in Growth Med | |
| Cryovial | 500,000 BCAEC (2nd passage) frozen in Basal Medium w/ 10% FBS & 10% DMSO | |
| Kit | Cryovial frozen BCAEC (B300-05), Growth Med (B211-500), Subcltr Rgnt Kit (090K) | |
| Proliferating | Shipped in Gr Med, 4th psg (flasks or plates) | |
| Doublings | At least 16 | |
| Applications | Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use. |
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