Human Small Airway Epithelial Cell Media
Human Small Airway Epithelial Cell Media
Small Airway Epithelial Cell Growth Medium: All-in-one ready-to-use
Type: Growth Medium
Size: 500 ml
Price: $152.00
Description
Human Small Airway Epithelial Cell Growth Medium is an optimized formulation intended to support the attachment, viability, proliferation, and, under appropriate culture conditions, differentiation of primary human small-airway epithelial cells in vitro. The medium is designed for research applications involving epithelial cells derived from the distal conducting airways, including the bronchioles.
In the human respiratory system, small-airway epithelial cells line the progressively narrower conducting airways distal to the bronchi, including the terminal bronchioles and, depending on the tissue source, respiratory bronchioles. The cellular composition of this epithelium differs from that of the larger airways and includes secretory club cells, ciliated cells, and other epithelial populations. Small-airway epithelial cells rest on a basement membrane overlying the airway wall and contribute to the maintenance of airway structure and function.
The small-airway epithelium contributes to pulmonary homeostasis by forming a selectively permeable barrier, participating in host defense against inhaled pathogens and particulates, regulating airway-surface liquid and ion transport, and contributing to mucociliary and secretory clearance. Secretory club cells produce airway-lining factors, while ciliated cells help move mucus and trapped material toward the larger airways. Small-airway epithelial cells also respond to inflammatory, toxic, infectious, and other pathological stimuli and participate in epithelial repair. Although the principal site of pulmonary gas exchange is the alveolar region, small-airway epithelial models are important for studying the conducting-to-respiratory airway transition and the epithelial processes that influence distal-lung physiology.
In experimental and translational research, primary human small-airway epithelial-cell cultures can support studies of airway biology, pulmonary disease mechanisms, drug discovery, inhalation toxicology, host–pathogen interactions, and respiratory epithelial injury and repair. When combined with appropriate extracellular-matrix conditions, air–liquid interface culture, co-culture systems, or microfluidic platforms, these cells may be used in models of airway barrier function, drug permeability, infection, and airway-on-a-chip applications. Researchers should validate cell viability, morphology, epithelial phenotype, differentiation state, barrier properties, and functional responsiveness under their specific culture conditions.
Human Small Airway Epithelial Cell Growth Medium is intended to support the culture and experimental use of primary human small-airway epithelial cells. It is not, by itself, a complete model of the distal lung or alveolar gas-exchange surface.
Media carefully optimized for the characteristics and requirements unique to Human Small Airway Epithelial Cells. Attention to detail ensures ideal cell health, viability, performance, physiology, morphology, consistency and data.
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