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Porcine Aortic Endothelial Cells: PAOEC
Porcine Aortic Endothelial Cells: PAOEC
Description
Porcine Aortic Endothelial Cells (PAOEC) provide a useful model system to study many aspects of cardiovascular function and disease. Co-culture of the artery endothelial cells with species-matched smooth muscle cells provides an ideal model for studying the interaction between these two cell types.
PAOEC from Cell Applications, Inc., and they have been utilized in a number of research publications, including those demonstrating that:
- H2O2 contributes to vascular dysfunction
- Cell survival under oxidative stress depends on phosphorylation of VEGFR-3
- Replication of swine fever virus regulates signal transduction pathways and gene expression
- Direct interactions between endothelial cells and T cells trigger release of proinflammatory molecules that play a role in graft rejection
- The tetraspanin CD82 is the recognition sensor responsible for rejection of xenotransplants
- Endothelial cells from heart valves align perpendicular to flow, while aortic endothelial cells align parallel to flow, indicating the need to match the cell types when designing engineered tissue devices
- Shear stress induces changes in expression of NO synthase, VCAM-1, c-jun, MCP-1 and ICAM-1
- Swine-to-human xenotransplantation can be improved by pretreating donors with vasopressin
- Endothelial implants can be designed to increase lumen diameter and replace heart valves
Details
| Tissue | Normal healthy porcine aorta | |
|---|---|---|
| QC | No bacteria, yeast, fungi, mycoplasma | |
| Character | DiI-Ac-LDL uptake: Positive | |
| Bioassay | Attach, spread, proliferate in Growth Med | |
| Cryovial | 500,000 PAOEC (1st passage) frozen in Basal Medium w/ 10% FBS, 10% DMSO | |
| Kit | Cryovial frozen PAOEC, Growth Medium (P211-500), Subculture Rgnt Kit (090K) | |
| Proliferating | Shipped in Gr Med, 2nd psg (flasks or plates) | |
| Doublings | At least 16 | |
| Applications | Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use. |
Resources
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