3D Skin Model

The 3D Skin Model is a highly physiological, three-dimensional cellular system of Human Epidermal Keratinocytes (HEK) for in vitro studies, offering an excellent tool to examine aspects of epithelial function and disease, particularly those related to skin biology and toxicology. 

Basic science and pharmaceutical researchers use the 3D Skin Model to replace animal tests for the assessment of skin irritation due to chemicals, skin-cream-based drugs and cosmetics. CAI’s Skin Model can also help avoid misclassification of chemicals and skin corrosion observed in animal systems ^{(1, 2)}. Other applications include phototoxicity, percutaneous absorption & penetration, wound healing and metabolism.  The cells are grown and differentiated into a stratified squamous epithelium on PCF sitting inserts with a liquid/air interface. Contact us for more information.

1. Eun & Nam, Exog Dermatol, 2:1–5 (2003)
2. York et al., Contact Dermatitis, 34:204 (1996)

Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */
table.MsoNormalTable
{mso-style-name:”Table Normal”;
mso-tstyle-rowband-size:0;
mso-tstyle-colband-size:0;
mso-style-noshow:yes;
mso-style-priority:99;
mso-style-parent:””;
mso-padding-alt:0in 5.4pt 0in 5.4pt;
mso-para-margin-top:0in;
mso-para-margin-right:0in;
mso-para-margin-bottom:8.0pt;
mso-para-margin-left:0in;
line-height:107%;
mso-pagination:widow-orphan;
font-size:11.0pt;
font-family:”Calibri”,sans-serif;
mso-ascii-font-family:Calibri;
mso-ascii-theme-font:minor-latin;
mso-hansi-font-family:Calibri;
mso-hansi-theme-font:minor-latin;}