Canine Osteoblasts, CnOb (L) von Kossa stained (R).
Canine Osteoblasts: CnOb
Description
Canine Osteoblasts (CnOb) from Cell Applications, Inc. provide an excellent model system for studies relevant to the skeletal system, including mechanisms of cancerogenesis.
Our CnOb have been used to:
- Define a biomarker profile of canine osteosarcoma, elucidate the roles of oncogenic STAT3 and canonical Wnt signaling pathways
- Develop personalized osteosarcoma treatments by testing Src inhibitor dasatinib, procaspase-3 activating compound PAC-1, HSP90 inhibitor STA‐1474 and STAT3 inhibitor LLL12.
Characterization: Positive for bone mineralization
Details
| Tissue | Normal healthy canine bone. | |
|---|---|---|
| QC | No bacteria, yeast, fungi, mycoplasma | |
| Character | Bone mineralization (von Kossa stain) | |
| Bioassay | Attach, spread, proliferate in Growth Med | |
| Cryovial | 500,000 CnOb (1st passage) frozen in Basal Medium w/ 10% FBS, 10% DMSO | |
| Kit | Cryovial frozen CnOb (Cn406-05), Growth Med (Cn417-500), Subcltr Rgnt Kit (090K) | |
| Proliferating | Shipped in Gr Med, 2nd psg (flasks or plates) | |
| Doublings | At least 10 | |
| Applications | Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use. |
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