Human Fibroblast-Like Synoviocytes-Osteoathritis: HFLS-OA, are isolated from the tissue of donors with arthritic disease.
Human Fibroblast-Like Synoviocytes: Osteoarthritis: HFLS-OA
Description
Human Fibroblast-Like Synoviocytes: Osteoarthritis (HFLS-OA)Â provide an excellent cellular model for studying synoviocyte physiology in relation to development and treatment of osteoarthritis.
HFLS-OA from Cell Applications, Inc. have been shown to:
- Possess osteogenic, chondrogenic and adipogenic potentials
- Express about half of the mesenchymal stem cell related transcription factors and molecular markers identified in a comprehensive study
- Involve LPA–EDG2 signaling in the pathogenesis of osteoarthritis via catabolic processes
- Employ parvorvirus B19 capsid proteins to activate synoviocyte migration and induction of the inflammatory response leading to acute symmetrical polyarthropathy
Finally, all three types of HFLS (normal, RA and OA), all from Cell Applications, Inc. were used to investigate the role of human endogenous retroviruses (HERVs) in development of rheumatoid arthritis, and suggest that activated expression of different forms of HERV contribute to development of rheumatoid arthritis symptoms by different mechanisms.
Details
| Tissue | Human synovial tissue from donor with osteoarthrits | |
|---|---|---|
| QC | No bacteria, yeast, fungi, mycoplasma, virus | |
| Cryovial | 500,000 HFLS-OA (2nd passage) frozen in Basal Medium w/ 10% FBS, 10% DMSO | |
| Kit | Croyvial frozen HFLS-OA (408OA-05a), Gr Med (415-500), Subcltr Rgnt Kit (090K) | |
| Proliferating | Shipped in Gr Med, 3rd psg (flasks or plates) | |
| Doublings | At least 5 | |
| Applications | Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use. |
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