Human iPSC-Derived Brown Fat Preadipocytes: i-HBrPAd

For the first time, Cell Applications, Inc. makes Human Brown Fat Preadipocytes (i-HBrPAd) available for research. Until now, studying human brown fat was nearly impossible due to its extreme scarcity in adults. But with our exclusive i-HBrPAd, derived from pluripotent stem cells and cryopreserved before maturation, researchers finally have direct access to this critical brown adipose tissue. Using our Preadipocyte Differentiation and Maturation Medium, i-HBrPAd cells fully mature in just 14 days and remain healthy and responsive for up to two weeks post-differentiation. These fat cells are over 97% positive for PRDM16, the essential thermogenic factor in brown fat development, and show the multilocular adipose vesicles unique to brown fat upon Oil Red O staining. With Cell Applications’ Brown Fat, researchers can now explore new frontiers in obesity, weight management and diabetes treatments and gain insights into brown fat development and its potential for in vivo generation. This world-first innovation changes what’s possible in metabolic research.