Bovine Brain Artery Endothelial Cells (BBAEC) are isolated from cerebral vascular tissue.
Bovine Brain Artery Endothelial Cells: BBAEC
Bovine Brain Artery Endothelial Cells (BBAEC) are specialized primary endothelial cells isolated from cerebral arteries.
Description
Bovine Brain Artery Endothelial Cells (BBAEC) are specialized primary endothelial cells isolated from cerebral arteries, serving as a commonly used model system to study macrovascular cerebrovascular biology and the physiological properties of the brain vasculature.
In vivo, endothelial cell populations lining the cerebral arteries form a critical part of the brain vasculature, regulating regional blood flow, vessel reactivity, and baseline barrier properties contributing to central nervous system homeostasis. These macrovascular arterial cells function in close spatial proximity to other neurovascular units — including astrocytes, pericytes, and smooth muscle cells — which together influence vascular tone, structural integrity, and local signaling dynamics. In experimental research, BBAEC can be used as a model to investigate endothelial activation, cell-cell signaling, and differential gene expression in response to inflammatory mediators, shear stress, and therapeutic agent treatment.
In broader cerebrovascular and neurodevelopmental research, BBAEC offer an established in vitro model to explore how arterial endothelial cells respond to metabolic or oxidative stress, helping to characterize pathways involved in cerebrovascular disease and vascular dysfunction. Utilizing primary cell cultures from defined macrovascular origins allows investigators to conduct robust comparative analysis between peripheral and central vessels. Standard characterization and experimental protocols — as reflected in product documentation and published research abstracts — commonly include evaluating endothelial-specific marker expression and verifying morphological consistency prior to functional assays.
Bovine Brain Artery Endothelial Cells (BBAEC) from Cell Applications, Inc.
Details
| Tissue: | Normal healthy bovine brain artery | |
|---|---|---|
| QC | No bacteria, yeast, fungi, mycoplasma | |
| Character | DiI-Ac-LDL uptake: Positive | |
| Bioassay | Attach, spread, proliferate in Growth Med | |
| Cryovial | 500,000 BBAEC (2nd passage) frozen in Basal Medium w/ 10% FBS, 10% DMSO | |
| Kit | Cryovial frozen BBAEC (B800-05), Growth Medium (B819-500), Subculture Rgnt Kit (090K) | |
| Doublings | At least 5 |
Resources
FAQs
Need More Help?
Visit our comprehensive FAQ page for detailed answers to common questions.
Need More Help?
Visit our comprehensive FAQ page for detailed answers to common questions.
Primary Cell FAQs