Canine Aortic Endothelial Cells: CnAOEC
Description
Canine Aortic Endothelial Cells (CnAOEC) from Cell Applications, Inc. provide a useful model to study cardiovascular diseases and test potential therapeutic agents, not only important from a veterinary perspective, but also having implications for human health. CnAOEC have been used in numerous research publications, for instance to: Adapt an immunomagnetic isolation protocol used in human patients to isolate circulating endothelial cells in dogs Investigate the mechanism of N-terminal portion of pro C-type natriuretic peptide (NT-pCNP), a sepsis biomarker in humans and dogs Demonstrate vasoprotective activity of pomegranate and soy isoflavons in order to prevent cardiovascular disease-related endothelial disfunction in dogs Compare growth of normal canine endothelial cells and aggressive canine hemangiosarcoma cells in a study investigating signaling pathways underlying hemangiosarcoma oncogenesis Understand reasons for reduced numbers of circulating progenitor cells in cardiovascular disease
Details
| Tissue | Normal healthy Canine aorta | |
|---|---|---|
| QC | No bacteria, yeast, fungi, mycoplasma | |
| Character | DiI-Ac-LDL uptake: Positive | |
| Bioassay | Attach, spread, proliferate in Growth Med | |
| Cryovial | 500,000 cells (2nd passage) frozen in Basal Medium w/ 10% FBS, 10% DMSO | |
| Kit | Cryovial frozen CnAOEC (Cn304-05), Growth Medium (Cn211-500), Subculture Rgnt Kit (090K), Attchmnt Fctr Soln (123-100) | |
| Proliferating | Shipped in Gr Med, 3rd psg (flasks or plates) | |
| Doublings | At least 16 | |
| Applications | Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use. |
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