Porcine Aortic Smooth Muscle Cells: PAOSMC (L), immunolabeled for smooth muscle-specific alpha-actin using the ABC method (R).
Porcine Aortic Smooth Muscle Cells: PAOSMC
Description
Porcine Aortic Smooth Muscle Cells (PAOSMC) from Cell Applications, Inc. were used to investigate
- Effects of heparin on smooth muscle cell proliferation
- Heparin-mediated induction of MKP-1 phosphatase, which dephosphorylates ERK, decreasing its activity
- Normalization of myocardin signaling in the diseased heart
- Restoration of heart function by targeted shRNA inhibition of myocardin genes
Finally, PAOSMC along with Porcine Aortic Endothelial cells, both from Cell Applications, Inc., have been used as controls in a study characterizing circulating endothelial progenitor cells
Characterization: positive for smooth muscle cell specific alpha-actin expression
Details
| Tissue | Normal healthy porcine aorta | |
|---|---|---|
| QC | No bacteria, yeast, fungi, mycoplasma | |
| Character | Smooth muscle specific α-actin positive | |
| Bioassay | Attach, spread, proliferate in Growth Med | |
| Cryopreserved | 500,000 PAOSMC (1st passage) frozen in Basal Medium w/ 10% FBS, 10% DMSO | |
| Kit | Cryovial frozen PAOSMC (P354-05), Grwth Med (P311-500), Subcltr Rgnt Kit (090K) | |
| Proliferating | Shipped in Gr Med, psg 2 (flasks or plates) | |
| Doublings | At least 16 | |
| Applications | Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use. |
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