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Porcine Coronary Artery Endothelial: PCAEC
Porcine Coronary Artery Endothelial Cells: PCAEC
Description
Porcine Coronary Artery Endothelial Cells (PCAEC) provide a useful tool to study artery endothelial function and metabolism. Arterial endothelial cells play critical roles in cardiac homeostasis, and insults to the endothelial cells have been linked to a variety of vascular diseases.
PCAEC from Cell Applications, Inc. have been used to:
- Investigate a new mechanism of obesity-associated vascular disease by demonstrating that resistin, an adipocyte-derived cytokine implemented in insulin resistance and diabetes, can cause endothelial dysfunction in coronary arteries through oxidative stress and down-regulation of NO synthase
- Show that secretoneurin activates expression of NO synthase and calmodulin, leading to endothelial relaxation
- Reveal anti-inflammatory, cardioprotective effects of a novel adenosine-lidocaine drug formulation by observing adhesion and transmigration
Details
| Tissue | Normal healthy porcine coronary artery | |
|---|---|---|
| QC | No bacteria, yeast, fungi, mycoplasma | |
| Character | DiI-Ac-LDL uptake: Positive | |
| Bioassay | Attach, spread, proliferate in Growth Med | |
| Cryovial | 500,000 PAOEC (2nd passage) frozen in Basal Medium w/ 10% FBS, 10% DMSO | |
| Kit | Cryovial frozen PCAEC (P300-05), Growth Medium (P211-500), Subculture Rgnt Kit (090K) | |
| Proliferating | Shipped in Gr Med, 3rd psg (flasks or plates) | |
| Doublings | At least 12 | |
| Applications | Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use. |
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