Rabbit Aortic Smooth Muscle Cells: RbAOSMC

In vivo, vascular smooth muscle cells populate the arterial wall, where they regulate vascular tone and structural remodeling. In experimental research, RbAOSMC — alongside comparative models utilizing animal cells, mouse systems, and related mesenchymal stem cell or immortalized cell lines — have been used in diverse functional studies. For instance, researchers have utilized RbAOSMC to demonstrate that the anti-restenosis drug probucol inhibits vascular smooth muscle cell proliferation by enhancing apoptosis and inducing heme oxygenase-1 expression. Furthermore, these cells have been applied to evaluate the performance of novel pH and carbon dioxide sensor systems designed for measuring real-time metabolic activity in cultured cells, as well as to characterize the receptor pharmacology, antiplatelet actions, and vascular pharmacology of novel receptor antagonists. Standard characterization confirms that RbAOSMC are positive for alpha smooth muscle actin expression using specific antibodies, verifying their smooth muscle phenotype.