Rat Mesenchymal Stem Cells: RMSC

Rat Mesenchymal Stem Cells (RMSC) have the potential to maintain multipotency and proliferate extensively in vitro. Bone marrow is the major blood creating organ, but in addition to supporting hematopoietic growth and differentiation, marrow stromal cells can be induced to produce cells of other connective tissues, such as bone, cartilage, and fat, as well as cells from neuroectodermal (neurons) and endodermal (hepatocytes) lineages. 

RMSC from Cell Applications, Inc. have been used to demonstrate:

• TGF-β stimulates production of MCP-1 by vascular smooth muscle cells, which attracts bone marrow stromal cells
• Cell migration can be stimulated by VPA and lithium through HDAC-CXCR4 and GSK-3β-MMP-9, respectively
• Therapeutic potential of marrow stromal stem cells depending on the extracellular matrix properties
• Combination of low-level laser therapy and transplantation of marrow stromal stem cells results in greater functional recovery after nerve crush injury
• Direct stem cell differentiation by altering physical topography of the substrate
• Surface materials to control cell-adhesion properties