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Induced Human Alveolar Epithelial Cell organoids offer several critical advantages. A primary advantage is the ability to maintain a stable, functional human phenotype for long periods, which can be difficult with traditional cell sources. Primary AEC2s harvested directly from donor lungs are fragile in culture: they lose their surfactant-producing characteristics and stop dividing within days. i-HAEpC2 Organoids are iPSC-derived with the unique DISCUS 3D system. iPSC-derived human hepatocyte organoids (i-HH) also overcome the fragility of tradtional hepatocyte models and provide a genetically stable and metabolically mature human liver model. This allows for “chronic” toxicity testing. In an organoid format, i-HH organoids express adult liver markers and can mimic a healthy adult liver. Liver function depends on the physical structure of the tissue. i-HH organoids naturally self-organize into 3D structures that develop bile canaliculi and display apical-basolateral polarity. iPSC-derived cells can be created from any individual. This allows generation from a patient with a specific genetic condition, rather than being limited to whatever donor tissue happens to be available. On April 10, 2025, the FDA announced a Roadmap to Reducing Animal Testing in Preclinical Safety Studies to reduce and phase out animal testing and promote alternatives such as advanced computer simulations…
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iPSC
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Human Induced Pluripotent Stem Cells: HiPSC
Human iPSC-Derived Alveolar Epithelial Cells: AEC2 / i-HAEpC2 (Organoids)
Human iPSC-Derived Brown Fat Preadipocytes: i-HBrPAd
Human iPSC-Derived Cardiac Cells: i-HCm
Human iPSC-Derived Hepatic Stellate Cells: i-HHSC
Human iPSC-Derived Hepatocytes: i-HH (Organoids)
Human iPSC-Derived Neural Stem Cells: i-HNSC
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