Canine Coronary Artery Smooth Muscle Cells: CnCASMC. Isolated from vessel from which the heart receives its own blood supply.
Canine Coronary Artery Smooth Muscle Cells: CnCASMC
Canine Coronary Artery Smooth Muscle Cells (CnCASMC) are specialized vascular smooth muscle cells derived from the coronary arteries of the dog.
Description
Canine Coronary Artery Smooth Muscle Cells (CnCASMC) provide a valuable animal model system to study key aspects of cardiovascular function and disease. As specialized vascular smooth muscle cells derived from the coronary arteries of the dog, these cells play an important structural and regulatory role within the coronary vasculature.
In vivo, vascular smooth muscle cells within coronary arteries contribute to the maintenance of vascular tone, structural integrity, and local blood flow regulation. Because smooth muscle behavior can vary significantly across distinct vascular beds, coronary-derived cells are specifically relevant to investigating coronary-specific physiology rather than acting as a universal proxy for all vascular structures. Furthermore, because physiological responses can vary across different species, using primary cells from canine models allows researchers to examine specific pharmacological and pathological mechanisms in a relevant mammalian system.
In research areas spanning cardiovascular and arterial disease, veterinary medicine, and veterinary science, researchers commonly use Canine Coronary Artery Smooth Muscle Cells (CnCASMC) to explore cellular mechanisms such as proliferation, contraction, and signal transduction pathways. Investigators typically characterize these cultures using appropriate smooth muscle markers and/or functional assays and standard quality control measures, such as mycoplasma screening, to support rigorous experimental studies.
Canine Coronary Artery Smooth Muscle Cells (CnCASMC) provide an excellent animal model system to study elements of cardiovascular function and disease.
Details
| Tissue | Normal healthy canine coronary artery | |
|---|---|---|
| QC | No bacteria, yeast, fungi, mycoplasma | |
| Character | Smooth muscle specific α-actin positive | |
| Bioassay | Attach, spread, proliferate in Growth Med | |
| Cryovial | 500,000 CnASMC (2nd passage) frozen in Basal Medium w/ 10% FBS, 10% DMSO | |
| Kit | Cryovial frozen CnCASMC (Cn350-05), Growth Medium (Cn311-500), Subcltr Rgnt Kit (090K) | |
| Doublings | At least 16 | |
| Applications | Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use. |
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