Human Carotid Artery Endothelial Cells-Asthma: HCtAEC-AS
Human Carotid Artery Endothelial Cells: Asthma: HCtAEC-AS
Description
Human Carotid Artery Endothelial Cells (HCtAEC)Â have been used to elucidate
- Molecular mechanisms of cerebral aneurism caused by haemodynamic (sheer) stress and inflammation
- PGE2-EP2 and NF-κB signaling
- Links between inflammation and neovascularization
- Cell migration, wound healing and tube formation responses
- Inhibition of angiogenesis
- CD40-CD154 signaling between endothelial cells and T cells
- EC stress responses
- That blood vessels from different tissues are highly heterogeneous and interact differently with leukocytes during the inflammation response.
Because of the complex heterogeneity that exists not only between different donors, but even between different vascular beds in the same individual, it would be prudent to confirm any new findings on primary cell lots coming from several different origins.
Cell Applications offers a wide panel of cells for use in asthma research and airway drug development, such as Bronchial & Tracheal Epithelial Cells, Pulmonary & Lung Microvascular Endothelial cells and others. Multiple donor profiles and lots are available. Asthma (AS) is a chronic disease that inflames and narrows air passageways in the lungs. This airflow obstruction, which can flare up at any time, causes shortness of breath and can be life-threating in severe cases. Asthma often starts during childhood, and while there’s no cure, scientists and pharmaceutical companies have made strides in understanding, treating and managing the disease.
Details
| Tissue | Human carotid artery from donor with asthma | |
|---|---|---|
| QC | No bacteria, yeast, fungi, mycoplasma, virus | |
| Character | Factor VIII-related Ag, DiI-Ac-LDL uptake | |
| Bioassay | Attach, spread, proliferate in Growth Med | |
| Cryovial | 500,000 HCtAEC-AS (2nd psg) Frozen in Basal Medium w/ 10% FBS, 10% DMSO | |
| Kit | Cryovial frozen HCtAEC-AS (3014AS-05a), Growth Medium (212-500), Subculture Rgnt Kit (090K) | |
| Proliferating | Shipped in Tsfr Med, 3rd psg (flasks or plates) | |
| Doublings | At least 10 | |
| Applications | Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use. |
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