Human Lung Microvascular Endothelial Cells-Asthma: HLMVEC-AS
Human Lung Microvascular Endothelial Cells: Asthma: HLMVEC-AS
Description
Human Lung Microvascular Endothelial Cells (HLMVEC) provide a useful tool for studying various aspects of pathology and biology of the pulmonary microvasculature in vitro. The pulmonary vasculature is of great physiological/pathological significance. It is now recognized to be a tissue composed of metabolically active, functionally responsive cells, that interact with circulating substrates and regulate the composition of systemic arterial blood, affect target organ functions, and contribute to thrombosis, hemostasis and immune reactions, as well as tumor metastasis.
HLMVEC from Cell Applications, Inc. have been used to elucidate the therapeutic effects of Angiotensin I-converting enzyme (ACE) inhibitors, and the results revealed that they provide an additional benefit to patients by activating bradykinin B1 receptor leading to prolonged nitric oxide (NO) production in endothelial cells and inhibition of PKCϵ.
Pre-Screened Human Lung Microvascular Endothelial Cells (S-HLMVEC) are select lots of HLMVEC that have been undergone further characterization. Pre-Screened HLMVEC have been stimulated by VEGF, and assayed for activation of VEGFR2 signaling pathway. More information about pre-screened endothelial cells can be found on the Pre-Screened Endothelial Cell Product Page.
Cell Applications offers a wide panel of cells for use in asthma research and airway drug development, such as Bronchial & Tracheal Epithelial Cells, Pulmonary & Lung Microvascular Endothelial cells and others. Multiple donor profiles and lots are available. Asthma (AS) is a chronic disease that inflames and narrows air passageways in the lungs. This airflow obstruction, which can flare up at any time, causes shortness of breath and can be life-threating in severe cases. Asthma often starts during childhood, and while there’s no cure, scientists and pharmaceutical companies have made strides in understanding, treating and managing the disease.
Details
| Tissue | Human lung (Asthma (AS)) | |
|---|---|---|
| QC | No bacteria, yeast, fungi, mycoplasma, virus | |
| Character | Factor VIII-related Ab, CD31 (PECAM-1), DiI-Ac-LDL uptake. | |
| Bioassay | Attach, spread on AFS-coated surface, proliferate in Growth Med | |
| Cryovial | 500,000 HLMVEC-AS (3rd passage) frozen in Basal Medium w/ 10% FBS, 10% DMSO | |
| Kit | Cryovial HLMVEC-AS (540AS-05), Gr Med (111-500), Attchmnt Fctr Soln (123-100), Sbcltr Rgnt Kit (090K) | |
| Proliferating | Shipped in Tsfr Med, 4th psg (flasks or plates) | |
| Doublings | At least 15 | |
| Applications | Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use. |
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