Human Pulmonary Artery Smooth Muscle Cells: HPASMC. Â Cells isolated from the vessel that carries deoxygenated blood from the heart to the lungs.
Human Pulmonary Artery Smooth Muscle Cells: HPASMC
Description
Human Pulmonary Artery Smooth Muscle Cells (HPASMC) from Cell Applications, Inc. have been used to show that:
- Antitumor drugs can selectively target remodeled pulmonary vessels, but not normal vessels
- Serotonin induces their growth and activates the BMP receptor
- IL-22 promotes the growth of pulmonary vascular SMCs via a signaling mechanism that involves NADPH oxidase-dependent oxidation
- Inducers of pulmonary hypertension, characterized by thickened pulmonary arterial walls, can be suppressed by targeting gene transcription
- Cell growth can be suppressed by trans-retinoic acid by inducing expression of a known cell growth suppressor,
- Retinoic acid and its receptors may be involved in cell growth and pulmonary vascular remodeling
- Iron chelation exerts effects on vascular remodeling and is implicated for development of pulmonary hypertension as a result of ROS activity
Characterization:Â positive for smooth muscle cell specific alpha-actin expression
Details
| Tissue | Normal healthy human pulmonary artery | |
|---|---|---|
| QC | No bacteria, yeast, fungi, mycoplasma, virus | |
| Character | Smooth muscle specific α-actin positive | |
| Bioassay | Attach, spread, proliferate in Growth Med | |
| Cryovial | 500,000 HPASMC frozen in Basal Medium w/ 10% FBS, 10% DMSO | |
| Kit | Cryovial frozen HPASMC (352-05a), Growth Medium (311-500), Subcltr Rgnt Kit (090K) | |
| Proliferating | Shipped in Gr Med, 3rd psg (flasks or plates) | |
| Doublings | At least 16 | |
| Applications | Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use. |
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