Chicken Aortic Smooth Muscle Cells: CAOSMC. Isolated from the main vessel that supplies oxygenated blood to the circulatory system.
Chicken Aortic Smooth Muscle Cells: CAOSMC
Chicken Aortic Smooth Muscle Cells (CAOSMC) are specialized primary smooth muscle cells isolated from avian aortic cardiovascular tissue.
Description
Chicken Aortic Smooth Muscle Cells (CAOSMC) are specialized primary cell types isolated from avian cardiovascular tissue, specifically characterized by positive α-smooth muscle actin (α-SMA; ACTA2) expression. These primary aortic smcs (often evaluated alongside alternative model systems derived from the mouse or compared with human aorta preparations) provide a classical avian in vitro model for studying vascular smooth muscle biology and cardiovascular-relevant responses in systemic vessels across the thoracic and abdominal aortic segments.
To maintain experimental integrity and culture fidelity, rigorous quality control — including screening for common contaminants such as mycoplasma, bacteria, and yeast — must be performed in accordance with established protocols when handling materials and stocks thawed from liquid nitrogen storage, ensuring that cells do not exceed recommended passage limits during in vitro culture. In addition, researchers employ various analytical techniques, such as immunofluorescence and quantitative analysis, to characterize phenotype and signaling dynamics across different anatomical regions, ranging from the thoracic vasculature to the abdominal aorta.
Historically and in contemporary research, Chicken Aortic Smooth Muscle Cells (CAOSMC) have been used to investigate atherosclerosis-relevant mechanisms and pathways involved in atherogenesis and restenosis, and have been used with viral gene-delivery approaches (e.g., adenoviral vectors) in some studies. By modeling these processes — such as monitoring smooth muscle cell proliferation or examining cellular health — these vsmc cultures support broader investigations into vascular disease, hypertension, and mechanistic aspects relevant to aneurysm-like pathology (e.g., proliferation, phenotype switching, and cellular health), with each experimental result offering valuable comparative insights into smooth muscle cell biology across species.
Chicken Aortic Smooth Muscle Cells (CAOSMC) from Cell Applications, Inc. have been used in early avian models of atherosclerosis to elucidate molecular mechanisms and pathways involved in atherogenesis and restenosis and allowed for the development of an efficient and specific adenovirus-based gene transfer system.
Characterization: positive for smooth muscle cell specific alpha-actin expression
Details
| Tissue | Normal healthy chicken aorta | |
|---|---|---|
| QC | No bacteria, yeast, fungi, mycoplasma | |
| Character | Smooth muscle specific α-actin positive | |
| Bioassay | Attach, spread, proliferate in Gwoth Med | |
| Cryovial | 500,000 CAOSMC (2nd passage) frozen in Basal Medium w/ 10% FBS, 10% DMSO | |
| Kit | Cryovial frozen CAOSMC (C354-05), Grwth Medium (C311-500), Subcltr Rgnt Kit (090K) | |
| Proliferating | Shipped in Gr Med, 3rd psg (flasks or plates) | |
| Doublings | At least 10 | |
| Applications | Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use. |
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