Human Osteoblasts: HOb (L). Von Kossa stained- Human Osteoblasts (R). Bone forming cells.
Human Osteoblasts: HOb
Description
Human Osteoblasts (HOb) from Cell Applications, Inc. are Isolated from fetal or adult human bones. The cells, positive for bone mineralization, provide an excellent model system for studies relevant to the skeletal system.  Additionally, osteoblasts from osteoarthritis or rheumatoid arthritis donors are available.
Our HOb have been used to examine:
- Actions, signaling pathways and cross-talk of growth factors, cytokines and interleukins
- Nuclear factors and gene expression
- Cell proliferation and differentiation
- Bone formation, morphogenesis, and bone morphogenic proteins
- Mechanisms behind bone disorders and defects including bone loss, osteoporosis, osteoclast inhibition, periodontitis, arthritis and related matrix metalloproteinase production
- Cancers, such as osteosarcoma and oncogenes. For the pharmaceutical industry, the cells have been pivotal in developing
- New pharmaceutical treatment strategies and drug delivery methods
- Orthopedic implants and tissue engineering have also been positively impacted by osteoblast research
Details
| Tissue | Normal healthy human bone | |
|---|---|---|
| QC | No bacteria, yeast, fungi, mycoplasma, virus | |
| Character | Bone mineralization (Kossa stain) | |
| Bioassay | Attach, spread, proliferate in Growth Med | |
| Cryovial | 500,000 HOb (2nd passage) frozen in Basal Medium w/ 10% FBS, 10% DMSO | |
| Kit | Cryovial frozen HOb (406-05), Growth Medium (417-500), Subcltr Rgnt Kit (090K) | |
| Proliferating | Shipped in Gr Med, 3rd psg (flasks or plates) | |
| Doublings | At least 10 | |
| Applications | Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use. |
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