Product Sheet CA1220
Description
BACKGROUND Aquaporin 4 (AQP4) is a predominant water channel protein in mammalian brains, which is abundantly expressed in astrocytes throughout the central nervous system, particularly at the blood-brain and brain-cerebrospinal fluid barriers.1 AQP4 mediates bidirectional transport of water across astrocytes. Phenotype analysis of transgenic mice lacking AQP4 has provided compelling evidence for involvement of AQP4 in cerebral water balance, astrocyte migration, and neural signal transduction.2 AQP4 manipulation may serve as a novel therapeutic strategy for a variety of cerebral disorders including stroke, tumor, infection, hydrocephalus, epilepsy, and traumatic brain injury.3
REFERENCES
1. Manley GT et al.: Neuroscience, 129:983-91, 2004.
2. Verkman AS et al.: Biochim Biophys Acta. 1758:1085-93, 2006.
3. Manley GT et al.: Nat Med. 6:159-63, 2000.
2. Verkman AS et al.: Biochim Biophys Acta. 1758:1085-93, 2006.
3. Manley GT et al.: Nat Med. 6:159-63, 2000.
Products are for research use only. They are not intended for human, animal, or diagnostic applications.
(Click to Enlarge) Various primary cell lysates were subjected to Western Blot analysis using AQP4 Antibody, including: HUVEC: Human Umbilical Vein Endothelial Cells, HSkMC: Human Skeletal Muscle Cells, and the HL60 cell line.
Details
Cat.No.: | CA1220 |
Antigen: | Peptide containing the middle region sequence of human AQP4. |
Isotype: | Rabbit Polyclonal |
Species & predicted species cross- reactivity ( ): | Human, Mouse |
Applications & Suggested starting dilutions: | WB 1:1000 IP 1:50 IHC (Paraffin) 1:100 ICC n/d FACS n/d |
Predicted Molecular Weight of protein: | 37 kDa |
Specificity/Sensitivity: | Detects endogenous levels of AQP4 protein in normal primary cell lysates. |
Storage: | Store at 4° C for frequent use; at -20° C for at least one year. |
*Optimal working dilutions must be determined by end user.
Products
| Product | Size | CAT.# | Price | Quantity |
|---|---|---|---|---|
| Polyclonal Aquaporin 4 Antibody: Polyclonal Aquaporin 4 Antibody | Size: 100 ul | CAT.#: CA1220 | Price: $302.00 |