Kupffer cells are specialized macrophages lining the walls of the sinusoids in the liver. These macrophages are critical component of the mononuclear phagocytic system and associated with a variety of disease states including drug-induced liver injury, nonalcoholic fatty liver diseases (NASH) and hepatic fibrosis.
Rat Kupffer cells from Cell Applications, Inc. provide an excellent model system to study many aspects of human liver function, metabolism and pathophysiology. Primary culture of Rat Kupffer cells is suitable for cell-based assays including toxicity, drug screening and disease modeling, and is a valuable tool to study liver physiology and associated diseases.