Product Sheet CL0756

Description

BACKGROUND ErbB2 (also called HER2, Neu, and CD340) is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. It is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. However, ErbB receptors dimerise on ligand binding, and ErbB2 is the preferential dimerisation partner of other members of the ErbB family.1,2 ErbB2 is notable for its role in the pathogenesis of breast cancer and as a target of treatment. Approximately 15-20 percent of breast cancers have an amplification of the ErbB2 gene or overexpression of its protein product. It is important as the target of the monoclonal antibody trastuzumab (marketed as Herceptin). Trastuzumab is only effective in breast cancer where the ErbB2 receptor is overexpressed.3
 
REFERENCES  
1. Revillion, F. et al: Eur. J. Cancer 34 :791, 1998
2. Hynes, N. E & Lane, H. A.: Nat Rev Cancer. 5:341, 2005
3. Olayioye, M. A. : Breast Cancer Res 3:385, 2001
 
Products are for research use only. They are not intended for human, animal, or diagnostic applications.
(Click to Enlarge) Epidermal Growth Factor Receptor 2 | Erythroblastic Leukemia Viral Oncogene Homolog 2 (ErbB-2) Standard Curve: Using the Human ErbB-2 ELISA Kit, O.D. data was graphed against ErbB-2 protein concentration. The TMB reaction was incubated at 37°C for 18 min.

Details

Cat.No.:
CL0756
Target Protein Species:
Human
Range:
62.5 pg/ml – 4000 pg/ml
Specificity:
No detectable cross-reactivity
with any other cytokine.
Storage:
Store at 4°C. Use within 6 months.
 
ELISA Kits are based on standard sandwich enzyme-linked immunosorbent assay technology. Freshly prepared standards, samples, and solutions are recommended for best results.

Products

Product Size CAT.# Price Quantity
Human ErbB-2 ELISA Kit: Human Epidermal Growth Factor Receptor 2 / Erythroblastic Leukemia Viral Oncogene Homolog 2 ELISA Kit Size: 96 Wells CAT.#: CL0756 Price: $533.00
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