Instructions HC Normal
5 Important Cell Culture Rules
MSDS Cryopreserved Cells
Cell Apps Flyer Skeletal System Cells
Cell Apps Poster Primary Cells
Cell Applications Inc Brochure
Human Chondrocytes (HC) are derived from normal human articular cartilage, where they produce and maintain the extracellular matrix of cartilage, including type II collagen. Used widely in research, the cells are a gold standard control for cellular reprogramming and differentiation. Chondrocytes grown in monolayer culture on a solid surface tend to lose their phenotypic markers, no longer produce Collagen type II and sulfated proteoglycan, and de-differentiate to a fibroblast-like phenotype.
Examples of HC-based research include:
- Phenotypic characterization and differentiation into osteoclasts.
- Others employ chondrocytes to describe the molecular biology of cell receptors, signaling cascades, cytokine activation and gene regulation.
- The cells are implicated in apoptosis, cytotoxicity, and cartilage degradation seen in inflammatory disorders such as rheumatoid-, osteo- and Lyme disease-associated arthritis.
- By examining the effects of shear stress and mechanotransduction pathways, some hope to develop treatments to thwart erosive joint pathology.
- Some labs look at monoclonal antibody treatment, or inhibition of erosive matrix metalloproteinase enzymes, directed toward arthritis treatment.
- The cells also receive attention for potential clinical applications, since they adhere to medical implants and infiltrate scaffolds for cartilage regeneration.
Characterization: Positive for aggrecan after differentiation
Normal healthy human articular cartilage
No bacteria, yeast, fungi, mycoplasma, virus
Attach, spread, proliferate in Growth Med
500,000 HC (1st passage) frozen in Basal Medium w/ 10% FBS, 10% DMSO
Cryovial frozen HC (402-05), Growth Medium (411-500), Subculture Rgnt Kit (090K)
Shipped in Gr Med, 2nd psg (flasks or plates)
At least 10
Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use.
|Cryopreserved HC Total Kit: 5x10^5 Cells (Adult), Medium & Subculture Reagents (See Details tab for specifics)||Size: 1 Kit||CAT.#: 402K-05a||Price: $851.02|
|Cryopreserved HC Total Kit: 5x10^5 Cells (Fetal), Medium & Subculture Reagents (See Details tab for specifics)||Size: 1 Kit||CAT.#: 402K-05f||Price: $851.02|
|Cryopreserved HC, adult: Frozen HC (5x10^5)||Size: 1 Cryovial||CAT.#: 402-05a||Price: $704.94|
|Cryopreserved HC, fetal: Frozen HC (5x10^5)||Size: 1 Cryovial||CAT.#: 402-05f||Price: $704.94|
|Proliferating HC, adult: Actively growing, dividing cells, in medium||Size: T-25 Flask||CAT.#: 403-25a||Price: $704.94|
|Proliferating HC, adult: Actively growing, dividing cells, in medium||Size: T-75 Flask||CAT.#: 403-75a||Price: $909.43|
|Proliferating HC, adult: Actively growing, dividing cells, in medium||Size: 6 well||CAT.#: 403-6Wa||Price: $877.14|
|Proliferating HC, adult: Actively growing, dividing cells, in medium||Size: 96 Well||CAT.#: 403-96Wa||Price: $1,006.29|
|Proliferating HC, fetal: Actively growing, dividing cells, in medium||Size: T-25 Flask||CAT.#: 403-25f||Price: $704.94|
|Proliferating HC, fetal: Actively growing, dividing cells, in medium||Size: 6 Well||CAT.#: 403-6Wf||Price: $877.14|
|Proliferating HC, fetal: Actively growing, dividing cells, in medium||Size: T-75 Flask||CAT.#: 403-75f||Price: $909.43|
|Proliferating HC, fetal: Actively growing, dividing cells, in medium||Size: 96 Well||CAT.#: 403-96Wf||Price: $1,006.29|
|Human Chondrocyte Basal Medium: Basal medium (contains no growth supplement). Add GS before use.||Size: 500 ml||CAT.#: 410-500||Price: $53.81|
|Human Chondrocyte Differentiation Medium: Promotes cells to change from one type to another, more specialized||Size: 250 ml||CAT.#: 411D-250||Price: $95.79|
|Human Chondrocyte Differentiation Medium: Promotes cells to change from one type to another, more specialized, without Phenol Red||Size: 250 ml||CAT.#: 411DPR-250||Price: $110.70|
|Human Chondrocyte Growth Medium: All-in-one ready-to-use||Size: 500 ml||CAT.#: 411-500||Price: $102.24|
|Human Chondrocyte Growth Medium: Growth medium without phenol red||Size: 500 ml||CAT.#: 411PR-500||Price: $118.39|
|Human Chondrocyte Growth Medium Kit: Basal medium & growth supplement sold together packaged separately||Size: Yields 500 ml||CAT.#: 411K-500||Price: $110.85|
|Human Chondrocyte Growth Supplement: Added to Basal Medium to create Growth Medium||Size: 50 ml||CAT.#: 411-GS||Price: $57.04|
Extended Family Products
|Anti-MMP-1: Mouse MMP-1 Antibody||Size: 100 ul||CAT.#: CP10422||Price: $302.38|
|Cell Freezing Medium: For general cryopreservation of most primary cells. Contains FBS & DMSO.||Size: 50 ml||CAT.#: 040-50||Price: $53.81|
|CTGF: Human Connective Tissue Growth Factor||Size: 20 ug||CAT.#: RP1060-20||Price: $193.73|
|CTGF: Human Connective Tissue Growth Factor||Size: 100 ug||CAT.#: RP1060-100||Price: $484.31|
|CTGF: Human Connective Tissue Growth Factor||Size: 1000 ug||CAT.#: RP1060-1000||Price: $4,089.75|
|Cyto-X Colorimetric Cell Counting Reagent: 500 tests||Size: 1 Bottle||CAT.#: 028-01||Price: $138.84|
|Cyto-X Colorimetric Cell Counting Reagent: 100 tests||Size: Sample||CAT.#: 028-S||Price: $35.88|
|Cytofect™ Chondrocyte Transfection Kit: 175 x 24-Well Rxns||Size: 1 Kit||CAT.#: TF402K||Price: $430.50|
|Cytofect™ Chondrocyte Transfection Kit: 25 x 24-Well Rxns||Size: 1 Sample Kit||CAT.#: TF402KS||Price: $53.76|
|HC RNA: Total RNA prepared from Human Chondrocytes, Re-Differentiated, adult||Size: 10 ul||CAT.#: 402RD-R10a||Price: $452.03|
|HC RNA: Total RNA prepared from Human Chondrocytes, Re-Differentiated, adult||Size: 25 ul||CAT.#: 402RD-R25a||Price: $904.05|
|HC RNA: Total RNA prepared from Human Chondrocytes, Re-Differentiated, fetal||Size: 10 ul||CAT.#: 402RD-R10f||Price: $452.03|
|HC RNA: Total RNA prepared from Human Chondrocytes, Re-Differentiated, fetal||Size: 25 ul||CAT.#: 402RD-R25f||Price: $904.05|
|MMP-1 ELISA Kit, Human: Human Matrix Metalloproteinase-1 ELISA Kit||Size: 96 Wells||CAT.#: CL0458||Price: $495.08|
|Subculture Reagent Kit: 100 ml each of HBSS, Trypsin/EDTA & Trypsin Neutralizing Solution||Size: 1 Kit||CAT.#: 090K||Price: $54.89|
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Honda, K. 2011. Interleukin-6 and soluble interleukin-6 receptor suppress osteoclastic differentiation by inducing PGE<Sub>2</Sub> production in chondrocytes. Journal of Oral Science. 53:87-96.
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Yang, L., A. Guo, and J.-C. Gu. 2011. c-Jun N-terminal kinase and nuclear factor κB mediate nitric oxide-induced expression of matrix metalloproteinase-13. International Orthopaedics (SICOT). 35:1261-1266.
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Park, G., B. Ward, and K. Webster. 2009. Bioresorbable poly (lactic/glycolic acid) (PLGA) materials/scaffolds with modified surfaces to enhance chondrocyte adhesion and proliferation; for use in repair of articular cartilage. Patent US 7527803 B2.
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Khang, D., G.E. Park, and T.J. Webster. 2008. Enhanced chondrocyte densities on carbon nanotube composites: The combined role of nanosurface roughness and electrical stimulation. J. Biomed. Mat. Res. Part A. 86A:253-260.
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Price, R.L., K. Ellison, K.M. Haberstroh, and T.J. Webster. 2004. Nanometer surface roughness increases select osteoblast adhesion on carbon nanofiber compacts. Journal of Biomedical Materials Research Part A. 70A:129-138.
Rao, S.S. 2004. Electrospun PLLA/SWNT nanocomposite fibril for cartilage regeneration. Drexel University, PhD dissertation.
Savaiano, J.K., and T.J. Webster. 2004. Altered responses of chondrocytes to nanophase PLGA/nanophase titania composites. Biomaterials. 25:1205-1213.
Ellison, K.S., R.L. Price, K.M. Haberstroh, and T.J. Webster. 2003. Carbon nanofiber surface roughness increases osteoblast adhesion. In MRS Proceedings. Vol. 774. Cambridge Univ Press.
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Gutwein, L., and T. Webster. 2002. Osteoblast and Chrondrocyte Proliferation in the Presence of Alumina And Titania Nanoparticles. Journal of Nanoparticle Research. 4:231-238.
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Kay, S., A. Thapa, K.M. Haberstroh, and T.J. Webster. 2002. Nanostructured polymer/nanophase ceramic composites enhance osteoblast and chondrocyte adhesion. Tissue engineering. 8:753-761.
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Miller, D.C., A. Thapa, K.M. Haberstroh, and T.J. Webster. 2002b. Enhanced functions of cells on polymers with nanostructured surfaces. In Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint. Vol. 1. 755-756 vol.751.
Park, G., B. Ward, K. Park, and T. Webster. 2002. PLGA substrate with aligned and nano-sized surface structures and associated method. Patent Application US 20040214322 A1.
Price, R.L., K.M. Haberstroh, and T.J. Webster. 2002. Increased adhesion on carbon nanofiber/polymer composite materials. In Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, Proceedings. 1:625-626.
Saviano, J., G. Jun, S. Kay, and T. Webster. 2002. NANOCOMPOSITES INCREASE FUNCTIONS OF CHONDROCYTES. 2002. Volume 733E Materials Research Society Symposium, Polymer Nanocomposites, SYMPOSIUM T1.3.
Lin, B., J.M. Kidder, R. Noring, A.C. Steere, M.S. Klempner, and L.T. Hu. 2001. Differences in Synovial Fluid Levels of Matrix Metalloproteinases Suggest Separate Mechanisms of Pathogenesis in Lyme Arthritis before and after Antibiotic Treatment. Journal of Infectious Diseases. 184:174-180.