MSDS Cryopreserved Cells
Instructions CADMEC
5 Important Cell Culture Rules
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Cell Apps Flyer Endothelial Cells
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Description

Human Dermal Microvascular Endothelial Cells (CADMEC / HMVEC) from Cell Applications, Inc. provide an excellent model system to study many aspects of endothelial function and disease, especially those related to the microvasculature and capillary systems.  These cells were trademarked by Cell Applications, Inc. over 20 years ago, when they were first offered, and CADMEC™ stands for “Cell Applications’ Dermal Microvascular Endothelial Cells”.  HMVEC/CADMEC have been shown to express vWF, CD36 and CD31, are able to uptake DiI-Ac-LDL and are positive for functional activity by cytokine-stimulated leukocyte adherence.
 
Select HMVEC lots have been additionally tested to demonstrate stimulation-dependent angiogenesis and key endothelial cell signaling pathways (phosphorylation of VEGFR, Akt, MAPK, and expression of Tie2, eNOS, Axl and Etk/Bmx).  See Pre-Screened Endothelial Cell Product Pagefor more information.
 
CADMEC/HMVEC from Cell Applications, Inc. have been used in numerous research publications, for example to:
  • Show that cytokine-activated microvascular endothelial cells upregulate expression of α2-6-linked sialic acids which are the ligands for CD22 on the surface of the B cells, increasing the adhesion between the two cell types
  • Show that IL-1, TNF and IFN stimulated ICAM-1 and E-selectin production by microvascular endothelial cells and resulted in a higher leukocyte adhesion that could be prevented by dexamethasone
  • Demonstrate that FGF-2, but not FGF-13, induces proliferation of microvascular endothelial cells, and that neither growth factor affected IL-6 production
  • Map VEGF signaling pathway by demonstrating that c-Src phosphorylates VEGFR-2 and IQGAP1, leading to activation of b-Raf, causing endotheial cell proliferation and angiogenesis
  • Demonstrate that mechanical signals promote endothelial cell proliferation via VEGFR2/Akt signaling cascade leading to inactivation of GSK3β and preventing cyclin D1 degradation
  • Show that endothelial permeability caused by advanced glycation end products results from RhoA/ROCK and p38 dependent moesin phosphorylation leading to actin reorganization
  • Demonstrate, along with Human Coronary Artery Endothelial Cells, also from Cell Applications, Inc., the role of AMP-activated protein kinase (AMPK) in preservation of the tight junctions, explaining the heightened vascular permeability when AMPK is inhibited due to exposure to lipopolysaccharides during sepsis
  • Demonstrate that the endothelial to mesenchymal transition associated with portal venous stenosis is mediated by increased serum levels of TGF-b1 in idiopathic portal hypertension patients, which induced fibroblast-like morphology, reduction of CD34 expression, and induction of α-smooth muscle actin, COL1A1 and phospho-Smad2, and that BMP-7 was able to prevent these changes (Kitao, 2009);
  • Reveal a critical role for the α7 nAChR in mediating the effects of nicotine on the endothelium
  • Show that abnormal matrix composition characteristic for systemic sclerosis, leads to reduced proliferation, reduced NO-to-O2- ratio, increased apoptosis, and altered protein expression associated with endothelial to mesenchymal transition, all leading to impaired vascular function and angiogenesis
  • Develop anti-tumor apoptosis-inducing peptides that selectively target angiogenic cells and a targeted gene delivery system, PEI-g-PEG-RGD, for efficient expression of soluble fragment of VEGF receptor Flt-1 (sFlt-1) gene in order to inhibit tumor-related angiogenesis
  • Identify a novel tumor-derived angiogenic factor, gastrin-releasing peptide, and its small molecule inhibitor, 77427
  • Evaluate, along with Human Pulmonary Artery Endothelial Cells (HPAEC) and Human Umbilical Cord Vascular Endothelial Cells (HUVEC), all obtained from Cell Applications, Inc., the cytotoxic effects of a novel pore-forming protein, proposed as an anti-tumor agent
  • To confirm the antioxidant and anti-inflammatory effects of blueberry and cranberry anthocyanins and hydroxycinnamic acids against H2O2 and TNFα induced damage to microvascular endothelial cells, by demonstrating reduction in oxidative stress and lowered production of IL-8, MCP-1 and ICAM-1 and show that procyanidins isolated from cocoa inhibit the expression of ErbB2 gene, decreasing cell proliferation and angiogenesis (Kenny, 2004);
  • Demonstrate secretion of adipogenic factor(s) by microvascular endothelial cells
(Cllick to Enlarge) Cell Applications Dermal Microvascular Endothelial Cells / Human Microvascular Endothelial Cells (CADMEC / HMVEC) Mono-layer (L), vessel-like structures formed in an angiogenesis assay (M), and immunolabeled for CD31/PECAM (green).  Nuclei are visualized with PI (red) (R).

Details

Tissue
Normal healthy human neonatal foreskin or adult skin capillaries
QC
No bacteria, yeast, fungi, mycoplasma
Character
Factor VIII-related Ag, DiI-Ac-LDL uptake
Bioassay
Attach, spread, proliferate in Growth Med
Cryovial
500,000 CADMEC frozen in Basal Med w/ 10% FBS, 10% DMSO
Kit
Cryovial frozen CADMEC (100-05), Gr Med (112-500), Subcltr Rgnt Kit, 2 Attchmnt Factor-Coated T-25 Flasks (121-25-02), Attchmnt Fctr Soln (123-100)
Proliferating
Shipped in Tsfr Med, 3rd psg (flasks or plates)
Doublings
At least 16
Applications
Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use.
Instructions CADMEC

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MSDS Cryopreserved Cells

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Products

Product Size CAT.# Price Quantity
Cryopreserved CADMEC , Adult: 5x10^5 Cells (Adult), Medium & Subculture Reagents (See Details tab for specifics) Size: 1 Kit CAT.#: 100K-05a Price: $822.00
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Cryopreserved CADMEC, Adult: Frozen CADMEC (5x10^5) Size: 1 Cryovial CAT.#: 100-05a Price: $615.00
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Cryopreserved CADMEC, Neonatal: 5x10^5 Cells (Neonatal), Medium & Subculture Reagents (See Details tab for specifics) Size: 1 Kit CAT.#: 100K-05n Price: $802.00
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Cryopreserved CADMEC, Neonatal: Frozen CADMEC (5x10^5) Size: 1 Cryovial CAT.#: 100-05n Price: $595.00
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Cryopreserved CADMEC, Pre-Screened, Adult: 5x10^5 Cells (Pre-Screened, Adult), Medium & Subculture Reagents (See Details tab for specifics) Size: 1 Kit CAT.#: S100K-05a Price: $933.00
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Cryopreserved CADMEC, Pre-Screened, Adult: Frozen CADMEC/HMVEC (5x10^5) Size: 1 Cryovial CAT.#: S100-05a Price: $726.00
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Cryopreserved CADMEC, Pre-Screened, Neonatal: 5x10^5 Cells (Pre-Screened, Neonatal), Medium & Subculture Reagents (See Details tab for specifics) Size: 1 Kit CAT.#: S100K-05n Price: $912.00
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Cryopreserved CADMEC, Pre-Screened, Neonatal: Frozen CADMEC (5x10^5) Size: 1 Cryovial CAT.#: S100-05n Price: $705.00
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Proliferating CADMEC, Adult: Actively growing, dividing cells in medium Size: T-25 Flask CAT.#: 101-25a Price: $615.00
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Proliferating CADMEC, Adult: Actively growing, dividing cells in medium Size: T-75 Flask CAT.#: 101-75a Price: $805.00
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Proliferating CADMEC, Adult: Actively growing, dividing cells in medium Size: 6 Well CAT.#: 101-6Wa Price: $805.00
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Proliferating CADMEC, Adult: Actively growing, dividing cells in medium Size: 96 Well CAT.#: 101-96Wa Price: $925.00
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Proliferating CADMEC, Neonatal: Proliferating CADMEC Size: T-25 Flask CAT.#: 101-25n Price: $595.00
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Proliferating CADMEC, Neonatal: Proliferating CADMEC Size: T-75 Flask CAT.#: 101-75n Price: $785.00
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Proliferating CADMEC, Neonatal: Proliferating CADMEC Size: 6 well CAT.#: 101-6Wn Price: $785.00
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Proliferating CADMEC, Neonatal: Actively growing, dividing cells, in medium Size: 96 Well CAT.#: 101-96Wn Price: $905.00
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Proliferating CADMEC, Pre-Screened, Adult: Actively growing, dividing cells in medium Size: T-25 Flask CAT.#: S101-25a Price: $726.00
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Proliferating CADMEC, Pre-Screened, Adult: Actively growing, dividing cells in medium Size: T-75 Flask CAT.#: S101-75a Price: $931.00
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Proliferating CADMEC, Pre-Screened, Adult: Actively growing, dividing cells in medium Size: 6 Well CAT.#: S101-6Wa Price: $931.00
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Proliferating CADMEC, Pre-Screened, Adult: Actively growing, dividing cells in medium Size: 96 Well CAT.#: S101-96Wa Price: $1,060.00
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Related Products

Product Size CAT.# Price Quantity
CADMEC Basal Medium: Basal medium (contains no growth supplement).  Add GS before use. Size: 500 ml CAT.#: 110-500 Price: $57.00
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CADMEC Basal Medium wo Phenol Red: Basal medium without phenol red Size: 500 ml CAT.#: 110PR-500 Price: $73.00
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CADMEC Cord Formation Med wo Serum, Growth Factors: Cord formation medium without serum and growth factors Size: 500 ml CAT.#: 114-500 Price: $113.00
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CADMEC Cord Formation Med wo Serum, Growth Factors, Phenol Red: Cord formation medium without serum, growth factors and phenol red Size: 500 ml CAT.#: 114PR-500 Price: $118.00
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CADMEC Growth Medium: All-in-one ready-to-use Size: 500 ml CAT.#: 112-500 Price: $163.00
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CADMEC Growth Medium Kit: Basal medium & growth supplement sold together packaged separately Size: Yields 500 ml CAT.#: 112K-500 Price: $175.00
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CADMEC Growth Medium Kit wo Phenol Red: Growth Medium Kit without phenol red Size: yields 500 ml CAT.#: 112KPR-500 Price: $164.00
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CADMEC Growth Medium wo FBS: Growth medium without FBS Size: 500 ml CAT.#: 112F-500 Price: $175.00
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CADMEC Growth Medium wo Phenol Red: Growth Medium without phenol red Size: 500 ml CAT.#: 112PR-500 Price: $153.00
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CADMEC Growth Medium wo Phosphate: Growth medium without phospate Size: 500 ml CAT.#: 112P-500 Price: $153.00
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CADMEC Growth Supplement: Added to Basal Medium to create Growth Medium Size: 30 ml CAT.#: 112-GS Price: $118.00
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Extended Family Products

Product Size CAT.# Price Quantity
Anti-ICAM-1: Rabbit Intercellular Adhesion Molecule-1 Antibody Size: 100 ul CAT.#: CG1238 Price: $275.00
Attachment Factor Solution (AFS): AFS, contains Bovine Gelatin Size: 100 ml CAT.#: 123-100 Price: $19.00
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CADMEC RNA: Total RNA prepared from Human Dermal Microvascular Endothelial Cells, adult Size: 10 ug CAT.#: 100-R10a Price: $350.00
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CADMEC RNA: Total RNA prepared from Human Dermal Microvascular Endothelial Cells, adult Size: 25 ug CAT.#: 100-R25a Price: $700.00
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CADMEC RNA: Total RNA prepared from Human Dermal Microvascular Endothelial Cells, Stimulated, adult Size: 10 ug CAT.#: 100S-R10a Price: $409.00
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CADMEC RNA: Total RNA prepared from Human Dermal Microvascular Endothelial Cells, Stimulated, adult Size: 25 ug CAT.#: 100S-R25a Price: $818.00
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CADMEC RNA: Total RNA prepared from Human Dermal Microvscular Endothelial Cells, neonatal Size: 10 ug CAT.#: 100-R10n Price: $350.00
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CADMEC RNA: Total RNA prepared from Human Dermal Microvscular Endothelial Cells, neonatal Size: 25 ug CAT.#: 100-R25n Price: $700.00
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CADMEC RNA: Total RNA prepared from Human Dermal Microvascular Endothelial Cells, Stimulated, neonatal Size: 10 ug CAT.#: 100S-R10n Price: $409.00
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Cyto-X Cell Counting Reagent: 500 tests Size: 1 Bottle CAT.#: 028-01 Price: $139.00
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Cyto-X Cell Counting Reagent Sample: 100 tests Size: Sample CAT.#: 028-S Price: $36.00
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Cytofect™ Endothelial Cell Transfection Kit: 25 x 24-Well Rxns Size: 1 Sample Kit CAT.#: TF101KS Price: $54.00
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Cytofect™ Endothelial Cell Transfection Kit: 250 x 24-Well Rxns Size: 1 Kit CAT.#: TF101K Price: $431.00
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Freezing Medium: For general cryopreservation of most primary cells. Contains FBS & DMSO. Size: 50 ml CAT.#: 040-50 Price: $54.00
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Human E-Selectin ELISA Kit: Human E-Selectin ELISA Kit Size: 96 Wells CAT.#: CL0501 Price: $587.00
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Human Gamma-Interferon Inducible Protein 10 (IP-10 / CXCL10): Human gamma-Interferon Inducible Protein 10 Size: 25 ug CAT.#: RP1127-25 Price: $194.00
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Human Gamma-Interferon Inducible Protein 10 (IP-10 / CXCL10): Human gamma-Interferon Inducible Protein 10 Size: 100 ug CAT.#: RP1127-100 Price: $484.00
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Human Gamma-Interferon Inducible Protein 10 (IP-10 / CXCL10): Human gamma-Interferon Inducible Protein 10 Size: 1000 ug CAT.#: RP1127-1000 Price: $3,175.00
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Human ICAM-1 ELISA Kit: Human Intercellular Adhesion Molecule-1 ELISA Kit Size: 96 Wells CAT.#: CL0370 Price: $484.00
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Human P-Selectin ELISA Kit: Human P-Selectin ELISA Kit Size: 96 wells CAT.#: CL0505 Price: $517.00
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Human Vascular Endothelial Growth Factor-121 (VEGF-121): Human Vascular Endothelial Growth Factor-121 Size: 10 ug CAT.#: RP1116-10 Price: $194.00
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Human Vascular Endothelial Growth Factor-121 (VEGF-121): Human Vascular Endothelial Growth Factor-121 Size: 100 ug CAT.#: RP1116-100 Price: $484.00
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Human Vascular Endothelial Growth Factor-121 (VEGF-121): Human Vascular Endothelial Growth Factor-121 Size: 1000 ug CAT.#: RP1116-1000 Price: $4,090.00
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Human VEGF-121, Animal-Free: Human Vascular Endothelial Growth Factor-121, Animal-Free Size: 10 ug CAT.#: RP1116AF-10 Price: $213.00
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Human VEGF-121, Animal-Free: Human Vascular Endothelial Growth Factor-121, Animal-Free Size: 100 ug CAT.#: RP1116AF-100 Price: $533.00
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Human VEGF-121, Animal-Free: Human Vascular Endothelial Growth Factor-121, Animal-Free Size: 1000 ug CAT.#: RP1116AF-1000 Price: $4,499.00
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Human VEGF-c ELISA Kit: Human Vascular Endothelial Growth Factor C ELISA Kit Size: 96 Wells CAT.#: CL0588 Price: $581.00
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Polyclonal Vascular Endothelial Growth Factor Antibody: Polyclonal Vascular Endothelial Growth Factor Antibody Size: 100 ul CAT.#: CA1080 Price: $302.00
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Polyclonal Vascular Endothelial Growth Factor-C Antibody: Polyclonal Vascular Endothelial Growth Factor-C Antibody Size: 100 ul CAT.#: CB3778 Price: $302.00
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Polyclonal VEGF Receptor 1 Antibody: Polyclonal VEGF Receptor 1 Antibody Size: 100 ul CAT.#: CB3839 Price: $333.00
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Subculture Reagent Kit: 100 ml each of HBSS, Trypsin/EDTA & Trypsin Neutralizing Solution Size: 1 Kit CAT.#: 090K Price: $55.00
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Resources/Documents

5 Important Cell Culture Rules

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Cell Apps Flyer Cardiovascular Cells

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Cell Apps Flyer Endothelial Cells

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Cell Apps Flyer Skin Cells

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Cell Apps Poster Primary Cells

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Cell Applications Inc Brochure

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Publications

2017

Tan, W., Wang, J., Zhou, F., Gao, L., Rong, Y., Liu, H., Sukanthanag, A., Wang, G., Mihm, M.C., Chen, D.B. and Nelson, J.S., 2017. Coexistence of EphB1 and EphrinB2 in Port Wine Stain Endothelial Progenitor Cells Contributes to Clinicopathological Vasculature Dilatation. British Journal of Dermatology. DOI: 10.1111/bjd.15716.

2016
Betapudi, V., M. Shukla, R. Alluri, S. Merkulov and K. McCrae. 2016. Novel role for p56/Lck in regulation of endothelial cell survival and angiogenesis. FASEB J, 30:3515-3526.
McKerracher, L. and L. Bond. 2016. Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors. Patent Applications US 20160213664 A1.
2014
Termini, C., M. Cotter, K. Marjon, T. Buranda, K. Lidke and J. Gillette. 2014. The membrane scaffold CD82 regulates cell adhesion by altering α4 integrin stability and molecular density. Mol Biol Cell, 25:1560-1573.
2013
Castanares-Zapatero, D., C. Bouleti, C. Sommereyns, B. Gerber, C. Lecut, T. Mathivet, M. Horckmans, D. Communi, M. Foretz, J.L. Vanoverschelde, S. Germain, L. Bertrand, P.F. Laterre, C. Oury, B. Viollet, S. Horman, and C. Beauloye. 2013. Connection Between Cardiac Vascular Permeability, Myocardial Edema, and Inflammation During Sepsis: Role of the alpha1AMP-Activated Protein Kinase Isoform. Crit Care Med. 10.1097/CCM.0b013e31829866dc
2012
Abe, H., and S. Tajima. 2012. UVB irradiation downregulates type XVI collagen expression in mouse and human skin. Journal of Cosmetic Dermatology. 11:169-178.
Sato, Y., X. Ren, K. Harada, M. Sasaki, H. Morikawa, S. Shiomi, M. Honda, S. Kaneko, and Y. Nakanuma. 2012. Induction of elastin expression in vascular endothelial cells relates to hepatoportal sclerosis in idiopathic portal hypertension: possible link to serum antiendothelial cell antibodies. Clinical & Experimental Immunology. 167:532-542.
Wang, J., H. Liu, B. Chen, Q. Li, X. Huang, L. Wang, X. Guo, and Q. Huang. 2012. RhoA/ROCK-dependent moesin phosphorylation regulates AGE-induced endothelial cellular response. Cardiovascular Diabetology. 11:7.
2011
Cuttitta, F., A. Martinez, and W. Stetler-Stevenson. 2011. Methods for inhibiting angiogenesis with inhibitors of proadrenomedullin N-terminal 20 peptide (PAMP). Patent US 7862815 B2.
2010
Harris, L.J., P. Zhang, H. Abdollahi, N.A. Tarola, C. DiMatteo, S.E. McIlhenny, T.N. Tulenko, and P.J. DiMuzio. 2010. Availability of Adipose-Derived Stem Cells in Patients Undergoing Vascular Surgical Procedures. J. Surgical Research. 163:e105-e112.
Liu, J., and S. Agarwal. 2010. Mechanical signals activate vascular endothelial growth factor receptor-2 to upregulate endothelial cell proliferation during inflammation. The Journal of Immunology. 185:1215-1221.
2009
Fischer, L.J., S. McIlhenny, T. Tulenko, N. Golesorkhi, P. Zhang, R. Larson, J. Lombardi, I. Shapiro, and P.J. DiMuzio. 2009. Endothelial Differentiation of Adipose-Derived Stem Cells: Effects of Endothelial Cell Growth Supplement and Shear Force. Journal of Surgical Research. 152:157-166.
Guo, X., L. Wang, B. Chen, Q. Li, J. Wang, M. Zhao, W. Wu, P. Zhu, X. Huang, and Q. Huang. 2009. ERM protein moesin is phosphorylated by advanced glycation end products and modulates endothelial permeability. American Journal of Physiology-Heart and Circulatory Physiology. 297:H238-H246.
Gupta, A., C. Lobocki, S. Singh, M. Robertson, O.A. Akadiri, G. Malhotra, and I.T. Jackson. 2009. Actions and Comparative Efficacy of Phosphatidylcholine Formulation and Isolated Sodium Deoxycholate for Different Cell Types. Aesth Plast Surg. 33:346-352.
Kitao, A., Y. Sato, S. Sawada-Kitamura, K. Harada, M. Sasaki, H. Morikawa, S. Shiomi, M. Honda, O. Matsui, and Y. Nakanuma. 2009. Endothelial to mesenchymal transition via transforming growth factor-β1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension. The American journal of pathology. 175:616-626.
Wu, J.C., A. Chruscinski, V.A. De Jesus Perez, H. Singh, M. Pitsiouni, M. Rabinovitch, P.J. Utz, and J.P. Cooke. 2009. Cholinergic modulation of angiogenesis: role of the 7 nicotinic acetylcholine receptor. Journal of cellular biochemistry. 108:433-446.
2008
Cuttittta, F., A. Martinez, and W. Stetler-Stevenson. 2008. Compositions and methods for promoting angiogenesis. Patent US 7462593 B2.
Hu, J., C. Rosen, and L. Cao. 2008. Vascular endothelial growth factor 2. Patent US 7439333 B2.
Meyer, R.D., D.B. Sacks, and N. Rahimi. 2008. IQGAP1-dependent signaling pathway regulates endothelial cell proliferation and angiogenesis. PloS one. 3:e3848.
2007
Coman, T. Comprises nucleotide sequences associated with expression vector coding endothelial growth factor for use in diagnosis and treatment of tumor angiogenesis, inflammation, diabetic retinopathy, arthritis and psoriasis; wound healing agent. Patent US 7273751 B2.
Hu, J., C. Rosen, and L. Cao. 2007. Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2. Patent US 7186688 B1.
Igarashi, K., I. Sakimoto, K. Kataoka, K. Ohta, and M. Miura. 2007. Radiation-induced senescence-like phenotype in proliferating and plateau-phase vascular endothelial cells. Experimental cell research. 313:3326-3336.
2006
Fujiuchi, S., Y. Yamazaki, Y. Fujita, Y. Nishigaki, A. Taked, Y. Yamamoto, T. Fijikane, T. Shimizu, S. Osanai, T. Takahashi, and K. Kikuchi. 2006. S-Nitrosoglutathione (SNOG) Accumulates Hypoxia Inducible Factor-1α in Main Pulmonary Artery Endothelial Cells but not in Micro Pulmonary Vessel Endothelial Cells. In THE ARTERIAL CHEMORECEPTORS. Vol. 580. Y. Hayashida, C. Gonzalez, and H. Kondo, editors. Springer US. 63-71.
Hu, J., C. Rosen, and L. Cao. 2006. Polypeptide for use in the treatment of inflammation, rheumatoid arritis, psoriasis, and diabetic retinopathy. Patent US 7153942 B2.
Li, H., M. Adams, V. Calenda, and V. Fataccioli. 2006. Stimulating angiogenesis enhancing the repair of connective and support tissue, promoting the attachment, fixation and stabilization of tissue implants and enhancing wound healing. Patent US 7026299 B2.
2005
Hu, C. Rosen, and L. Cao. 2005. Administering anti-Flt4 antibody or an anti-VEGF-C antibody that inhibits binding between Flt4 ligand protein and Flt4 expressed in cells to treat breast cancer characterized by endothelial cells that express Flt4 tyrosine kinase. Patent Application US 20060025331 A1.
Hu, J., C. Rosen, and L. Cao. 2005. Produced by recombinant techniques and polynucleotides encoding the polypeptides; used to stimulate angiogenesis for wound healing and for vascular tissue repair. Patent Application US 20050176103 A1.
Ji, H., P.A. Abshire, M. Urdaneta, and E. Smela. 2005. CMOS contact imager for monitoring cultured cells. In Circuits and Systems, 2005. ISCAS 2005. IEEE International Symposium on. IEEE. 3491-3494.
Kim, W.J., J.W. Yockman, M. Lee, J.H. Jeong, Y.-H. Kim, and S.W. Kim. 2005. Soluble Flt-1 gene delivery using PEI-g-PEG-RGD conjugate for anti-angiogenesis. Journal of controlled release. 106:224-234.
Li, H., M. Adams, V. Calenda, and V. Fataccioli. 2005. Connective tissue growth factor-2. Patent Application US 20060052328 A1.
Martinez, A., E. Zudaire, M. Julian, T.W. Moody, and F. Cuttitta. 2005. Gastrin-releasing peptide (GRP) induces angiogenesis and the specific GRP blocker 77427 inhibits tumor growth in vitro and in vivo. Oncogene. 24:4106-4113.
2004
Hu, J., L. Cao, and A. Rosen. 20045. Nucleotide sequences coding polypeptide for use in the diagnosis, prevention and treatment of cancer, inflammation, diabetic retinopathy, rheumatoid arthritis and psoriasis. Patent US 6734285 B2.
Kenny, T.P., C.L. Keen, P. Jones, H.-J. Kung, H.H. Schmitz, and M.E. Gershwin. 2004. Cocoa procyanidins inhibit proliferation and angiogenic signals in human dermal microvascular endothelial cells following stimulation by low-level H2O2. Experimental biology and medicine. 229:765-771.
2003
Duan, D., and S. Rosen. 2003. Bone marrow specific protein. Patent Application US 20030191062 A1.
Ellerby, H.M., S. Lee, L.M. Ellerby, S. Chen, T. Kiyota, G. del Rio, G. Sugihara, Y. Sun, D.E. Bredesen, W. Arap, and R. Pasqualini. 2003. An Artificially Designed Pore-forming Protein with Anti-tumor Effects. Journal of Biological Chemistry. 278:35311-35316.
Hu, J., L. Cao, and C. Rosen. 2003. Comprises nucleotide sequences coding mitogens for treating psoriasis, vision defects, tumors and arthritis. Patent Application US 20040143103 A1.
2001
Li, H., M. Adams, V. Calenda, and V. Fataccioli. 2001. Connective tissue growth factor-2. Patent Application US 20030012768 A1.
Coleman, T. 2001. Vascular endothelial growth factor-2. Patent Application US 20030215921 A1.
Hutley, L.J., A.C. Herington, W. Shurety, C. Cheung, D.A. Vesey, D.P. Cameron, and J.B. Prins. 2001. Human adipose tissue endothelial cells promote preadipocyte proliferation. American Journal of Physiology-Endocrinology And Metabolism. 281:E1037-E1044.
Patel, N.A., J.A. Patel, M.F. Stins, K.S. Kim, and S.L. Chang. 2001. Dexamethasone Affects Cytokine-Mediated Adhesion of HL-60 Human Promyelocytic Leukemia Cells to Cultured Dermal Microvascular Endothelial Cells. Clinical Immunology. 99:387-394.
Ruoslahti, E., R. Pasqualini, W. Arap, B. Dale, and E. Michael. 2001. Chimeric prostate-homing peptide comprising a sequence of serine-methionine-serine-isoleucine-alanine-arganine-leucine, or functionally equivalent sequence. Patent Application US 20010046498 A1.
2000
Hu, J., C. Rosen, and L. Cao. 2000. Amino acid sequence; for angiogenesis inhibitors, antitumor agents, antiinflammatory agents, antiarthritic agents for rheumatoid arthritis, wound healing agents; treatment of diabetic retinopathy and psoriasis. Patent US 6040157 A.
1998
Leung, K.H., V. Pippalla, A. Kreutter, and M. Chandler. 1998. Functional effects of FGF-13 on human lung fibroblasts, dermal microvascular endothelial cells, and aortic smooth muscle cells. Biochem. & Biophys. Research Communic. 250:137-142.
1997
Chang, C., Y. Lee, J. Yang, C. Weng, and F. Wei. 1997. Pilot in Vitro Toxicity Study of 5-ALA and Photofrin® in Microvascular Endothelial Cell Cultures. J Clinical Laser Med & Surg, 15:83-87.
1996
DERYUGINA, E.I., A. STRONGIN, C. YU, and M.A. BOURDON. 1996. A novel monoclonal antibody, L1A3, is directed to the functional site of the αv integrin subunit. Hybridoma. 15:279-288.
1995
Hanasaki, K., A. Varki, and L.D. Powell. 1995. CD22-mediated Cell Adhesion to Cytokine-activated Human Endothelial Cells POSITIVE AND NEGATIVE REGULATION BY α2-6-SIALYLATION OF CELLULAR GLYCOPROTEINS. J.  Biol. Chem. 270:7533-7542.