Instructions HFLS-RA
MSDS Cryopreserved Cells
Cell Apps Flyer Skeletal System Cells
5 Important Cell Culture Rules
Cell Apps Poster Primary Cells



Human Fibroblast-Like Synoviocytes: Rheumatoid Arthritis (HFLS-RA) provide an excellent cellular model for studying synoviocyte physiology in relation to development and treatment of rheumatoid arthritis. 

HFLS-RA from Cell Applications, Inc. have been used in research to evaluate:
  • Signaling pathways implicated in the development of joint inflammation and rheumatoid arthritis
  • Contribution of EBV to nonresolving rheumatoid arthritis inflammation through inducing IL-6 production by synoviocytes
  • Anti-inflammatory and antirheumatic activity of various compounds, such as celastrol, triptolide, arsenic trioxide, bucillamine, therapeutic lyposomes, anti-IL-6R and anti-CD319 antibodies, inhibitors of NF-κB, methionine aminopeptidase-2, Tpl2, aryl hydrocarbon receptor, p38 MAP kinase
  • Beneficial anti-inflammatory effects of low level light therapy
  • Causes of metalloproteinase induction in patients with Lyme disease-associated arthritis
  • Adenovirus-based siRNA delivery systems
  • Causative agents, immunopathological mechanisms and signal transduction pathways leading to joint inflammation in rheumatoid arthritis
  • The role of estrogen signaling in increasing inflammation
  • Anti-inflammatory properties of herbal compound Sinomenine suggested for rheumatoid arthritis treatment
  • Effects of extracellular matrix composition on cell attachment and migration relevant to T-cell function in inflamed tissues
  • Involvement of capsid proteins of parvorvirus B19 in activating synoviocyte migration and induction of the inflammatory response leading to acute symmetrical polyarthropathy
  • The role of human endogenous retroviruses (HERVs) in development of rheumatoid arthritis, and suggest that activated expression of different forms of HERV contribute to development of rheumatoid arthritis symptoms by different mechanisms


(Click to Enlarge) Human Fibroblast-Like Synoviocytes-Rheumatoid Arthritis: HFLS-RA.  Cells that line the joints, producing synovial fluid.  In RA, synovial cells express genes and erosive enzymes that contribute to joint degradation.


Human synovial tissue from donor w/ rheumatoid arthritis
No bacteria, yeast, fungi, mycoplasma, virus
500,000 HFLS-RA frozen in Basal Medium w/ 10% FBS, 10% DMSO
Cryovial frozen HFLS-RA (408RA-05a), Gr Med (415-500), Subcltr Rgnt Kit (090K)
Shipped in Gr Med, 3rd psg (flasks or plates)
At least 5
Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use.
Instructions HFLS-RA

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MSDS Cryopreserved Cells

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Product Size CAT.# Price Quantity
Cryopreserved HFLS-RA Total Kit, adult: 5x10^5 Cells (from donor with Rheumotoid Arthritis, Adult), Medium & Subculture Reagents (See Details tab for specifics) Size: 1 Kit CAT.#: 408RAK-05a Price: $890.89
Cryopreserved HFLS-RA, adult: Frozen HFLS from donor with Rheumotoid Arthritis (5x10^5) Size: 1 Cryovial CAT.#: 408RA-05a Price: $747.99
Proliferating HFLS-RA, adult: Actively growing, dividing cells in medium, from donor with Rheumotoid Arthritis Size: T-25 Flask CAT.#: 409RA-25a Price: $747.99
Proliferating HFLS-RA, adult: Actively growing, dividing cells in medium, from donor with Rheumotoid Arthritis Size: T-75 Flask CAT.#: 409RA-75a Price: $952.48
Proliferating HFLS-RA, adult: Actively growing, dividing cells in medium, from donor with Rheumotoid Arthritis Size: 6 Well CAT.#: 409RA-6Wa Price: $913.74
Proliferating HFLS-RA, adult: Actively growing, dividing cells in medium, from donor with Rheumotoid Arthritis Size: 96 Well CAT.#: 409RA-96Wa Price: $1,042.89

Related Products

Product Size CAT.# Price Quantity
Human Synoviocyte Basal Medium: Basal medium (contains no growth supplement).  Add GS before use. Size: 500 ml CAT.#: 414-500 Price: $53.81
Human Synoviocyte Growth Medium: All-in-one ready-to-use Size: 500 ml CAT.#: 415-500 Price: $102.24
Human Synoviocyte Growth Medium: Growth medium without antibiotics Size: 500 ml CAT.#: 415A-500 Price: $110.85
Human Synoviocyte Growth Medium: Growth medium without FBS Size: 500 ml CAT.#: 415F-500 Price: $110.85
Human Synoviocyte Growth Medium Kit: Basal medium & growth supplement sold together packaged separately Size: Yields 500 ml CAT.#: 415K-500 Price: $110.85
Human Synoviocyte Growth Supplement: Added to Basal Medium to create Growth Medium Size: 50 ml CAT.#: 415-GS Price: $57.04
Subculture Reagent Kit: 100 ml each of HBSS, Trypsin/EDTA & Trypsin Neutralizing Solution Size: 1 Kit CAT.#: 090K Price: $54.89

Extended Family Products

Product Size CAT.# Price Quantity
Cyto-X Colorimetric Cell Counting Reagent: 500 tests Size: 1 Bottle CAT.#: 028-01 Price: $138.84
Cyto-X Colorimetric Cell Counting Reagent: 100 tests Size: Sample CAT.#: 028-S Price: $35.88
HFLS-RA RNA: Total RNA prepared from Human Fibroblast-Like Synoviocytes-Rheumatoid Arthritis, adult Size: 10 ug CAT.#: 408RA-R10a Price: $349.78
HFLS-RA RNA: Total RNA prepared from Human Fibroblast-Like Synoviocytes-Rheumatoid Arthritis, adult Size: 25 ug CAT.#: 408RA-R25a Price: $699.56


Cell Apps Flyer Skeletal System Cells

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5 Important Cell Culture Rules

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Cell Apps Poster Primary Cells

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McCoy, J., D. Walkenhorst, K. McCauley, H. Elaasar, J. Everett, and K. Mix. 2015. Orphan nuclear receptor NR4A2 induces transcription of the immunomodulatory peptide hormone prolactin. Journal of Inflammation, 12:13.
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Lahoti, T.S., K. John, J.M. Hughes, A. Kusnadi, I.A. Murray, G. Krishnegowda, S. Amin, and G.H. Perdew. 2013. Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signalling in primary human fibroblast-like synoviocytes. Annals of the Rheumatic Diseases. 72:1708-1716.
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Mei, Y., Y. Zheng, H. Wang, J. Gao, D. Liu, Y. Zhao, and Z. Zhang. 2011. Arsenic trioxide induces apoptosis of fibroblast-like synoviocytes and represents antiarthritis effect in experimental model of rheumatoid arthritis. The Journal of Rheumatology. 38:36-43.
Negishi, Y., Y. Tsunoda, Y. Endo-Takahashi, Y. Oda, R. Suzuki, K. Maruyama, M. Yamamoto, and Y. Aramaki. 2011. Local gene delivery system by bubble liposomes and ultrasound exposure into joint synovium. Journal of drug delivery. 2011:Article ID 203986.
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Konomi, I., Y.I. DANTSUJI, and A. Nagayama. 2009. Characterization of a Persistent Chlamydial Infection and the Role of Toll like Receptors in the IL 6 Secretion in Chlamydia Trachomatis Infected Human Synovial Fibroblasts. Fukuoka Daigaku igaku kiyō. 36:205-214.
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Akasaka, Y., K. Abe, T. Sato, and H. Inoue. 2005. Regulation of neurokinin-1 receptor messenger RNA expression in synovial fibroblasts of patients with rheumatoid arthritis. Neuropeptides. 39:467-474.
Keith, J.C., Jr., L.M. Albert, Y. Leathurby, M. Follettie, L. Wang, L. Borges-Marcucci, C.C. Chadwick, R.J. Steffan, and D.C. Harnish. 2005. The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-kappa B transcriptional activity in models of rheumatoid arthritis. Arthritis research & therapy. 7:R427-438.
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Arts, G.-J., E. Langemeijer, R. Tissingh, L. Ma, H. Pavliska, K. Dokic, R. Dooijes, E. Mešić, R. Clasen, and F. Michiels. 2003. Adenoviral vectors expressing siRNAs for discovery and validation of gene function. Genome res. 13:2325-2332.
Lin, B., J.M. Kidder, R. Noring, A.C. Steere, M.S. Klempner, and L.T. Hu. 2001. Differences in Synovial Fluid Levels of Matrix Metalloproteinases Suggest Separate Mechanisms of Pathogenesis in Lyme Arthritis before and after Antibiotic Treatment. Journal of Infectious Diseases. 184:174-180.
Privat, S.J., A. Oo, and L.D. Waterbury. 2001. Production of interleukin-6, but not interleukin-8, induced by TNF-alpha or IL-1 beta in human fibroblast-like synoviocyte increases over cell passage. Proceedings of the Western Pharmacology Society. 44:9-13.
Yano, K., N. Nakagawa, H. Yasuda, E. Tsuda, and K. Higashio. 2001. Synovial cells from a patient with rheumatoid arthritis produce osteoclastogenesis inhibitory factor/osteoprotegerin: reciprocal regulation of the production by inflammatory cytokines and basic fibroblast growth factor. Journal of bone and mineral metabolism. 19:365-372.