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Human Fibroblast-Like Synoviocytes: Rheumatoid Arthritis (HFLS-RA) provide an excellent cellular model for studying synoviocyte physiology in relation to development and treatment of rheumatoid arthritis.
HFLS-RA from Cell Applications, Inc. have been used in research to evaluate:
- Signaling pathways implicated in the development of joint inflammation and rheumatoid arthritis
- Contribution of EBV to nonresolving rheumatoid arthritis inflammation through inducing IL-6 production by synoviocytes
- Anti-inflammatory and antirheumatic activity of various compounds, such as celastrol, triptolide, arsenic trioxide, bucillamine, therapeutic lyposomes, anti-IL-6R and anti-CD319 antibodies, inhibitors of NF-κB, methionine aminopeptidase-2, Tpl2, aryl hydrocarbon receptor, p38 MAP kinase
- Beneficial anti-inflammatory effects of low level light therapy
- Causes of metalloproteinase induction in patients with Lyme disease-associated arthritis
- Adenovirus-based siRNA delivery systems
- Causative agents, immunopathological mechanisms and signal transduction pathways leading to joint inflammation in rheumatoid arthritis
- The role of estrogen signaling in increasing inflammation
- Anti-inflammatory properties of herbal compound Sinomenine suggested for rheumatoid arthritis treatment
- Effects of extracellular matrix composition on cell attachment and migration relevant to T-cell function in inflamed tissues
- Involvement of capsid proteins of parvorvirus B19 in activating synoviocyte migration and induction of the inflammatory response leading to acute symmetrical polyarthropathy
- The role of human endogenous retroviruses (HERVs) in development of rheumatoid arthritis, and suggest that activated expression of different forms of HERV contribute to development of rheumatoid arthritis symptoms by different mechanisms
Human synovial tissue from donor w/ rheumatoid arthritis
No bacteria, yeast, fungi, mycoplasma, virus
500,000 HFLS-RA frozen in Basal Medium w/ 10% FBS, 10% DMSO
Cryovial frozen HFLS-RA (408RA-05a), Gr Med (415-500), Subcltr Rgnt Kit (090K)
Shipped in Gr Med, 3rd psg (flasks or plates)
|At least 5|
|Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use.|
|Cryopreserved HFLS-RA, Adult: 5x10^5 Cells (from donor with Rheumotoid Arthritis, Adult), Medium & Subculture Reagents (See Details tab for specifics)||Size: 1 Kit||CAT.#: 408RAK-05a||Price: $891.00|
|Cryopreserved HFLS-RA, Adult: Frozen HFLS from donor with Rheumotoid Arthritis (5x10^5)||Size: 1 Cryovial||CAT.#: 408RA-05a||Price: $748.00|
|Proliferating HFLS-RA, Adult: Actively growing, dividing cells in medium, from donor with Rheumotoid Arthritis||Size: T-25 Flask||CAT.#: 409RA-25a||Price: $748.00|
|Proliferating HFLS-RA, Adult: Actively growing, dividing cells in medium, from donor with Rheumotoid Arthritis||Size: T-75 Flask||CAT.#: 409RA-75a||Price: $952.00|
|Proliferating HFLS-RA, Adult: Actively growing, dividing cells in medium, from donor with Rheumotoid Arthritis||Size: 6 Well||CAT.#: 409RA-6Wa||Price: $914.00|
|Size: 96 Well||CAT.#: 409RA-96Wa||Price: $1,043.00|
|HFLS Basal Medium: Basal medium (contains no growth supplement). Add GS before use.||Size: 500 ml||CAT.#: 414-500||Price: $54.00|
|HFLS Growth Medium: All-in-one ready-to-use||Size: 500 ml||CAT.#: 415-500||Price: $102.00|
|HFLS Growth Medium Kit: Basal medium & growth supplement sold together packaged separately||Size: Yields 500 ml||CAT.#: 415K-500||Price: $111.00|
|HFLS Growth Medium wo Antibiotics: Growth medium without antibiotics||Size: 500 ml||CAT.#: 415A-500||Price: $111.00|
|HFLS Growth Medium wo FBS: Growth medium without FBS||Size: 500 ml||CAT.#: 415F-500||Price: $111.00|
|HFLS Growth Supplement: Added to Basal Medium to create Growth Medium||Size: 50 ml||CAT.#: 415-GS||Price: $57.00|
|Subculture Reagent Kit: 100 ml each of HBSS, Trypsin/EDTA & Trypsin Neutralizing Solution||Size: 1 Kit||CAT.#: 090K||Price: $55.00|
Extended Family Products
|Cyto-X Cell Counting Reagent: 500 tests||Size: 1 Bottle||CAT.#: 028-01||Price: $139.00|
|Cyto-X Cell Counting Reagent Sample: 100 tests||Size: Sample||CAT.#: 028-S||Price: $36.00|
|HFLS-RA RNA, Adult: Total RNA prepared from Human Fibroblast-Like Synoviocytes-Rheumatoid Arthritis, adult||Size: 10 ug||CAT.#: 408RA-R10a||Price: $350.00|
|HFLS-RA RNA, Adult: Total RNA prepared from Human Fibroblast-Like Synoviocytes-Rheumatoid Arthritis, adult||Size: 25 ug||CAT.#: 408RA-R25a||Price: $700.00|
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Fujii, W., Y. Kawahito, H. Nagahara, Y. Kukida, T. Seno, A. Yamamoto, M. Kohno, R. Oda, D. Taniguchi, H. Fujiwara, A. Ejima, T. Kishida, O. Mazda, and E. Ashihara. 2015. Monocarboxylate transporter 4, associated with the acidification of synovial fluid, is a novel therapeutic target for inflammatory arthritis. Arthritis & Rheumatology, DOI: 10.1002/art.39270.
Jie, L., R.Huang, W. Sun, S. Wei, Y. Chu, Q. Huang, and H. Du. 2015. Role of cysteine‑rich angiogenic inducer 61 in fibroblast‑like synovial cell proliferation and invasion in rheumatoid arthritis. Molecular Medicine Reports, 11:917-923.
Lauzier, A., R. Lavoie, M. Charbonneau, B. Gouin-Boisvert, K. Harper, and C. Dubois. 2015. Snail Is a Critical Mediator of Invadosome Formation and Joint Degradation in Arthritis. Am J Pathol, http://dx.doi.org/10.1016/j.ajpath.2015.10.021.
Lee, F., J. Lim, M. Reithofer, S. Lee, J. Chung, C. Hauser, and M. Kurisawa. 2015. Synthesis and bioactivity of a conjugate composed of green tea catechins and hyaluronic acid. Polymer Chemistry, 6:4462-4472.
McCoy, J., D. Walkenhorst, K. McCauley, H. Elaasar, J. Everett, and K. Mix. 2015. Orphan nuclear receptor NR4A2 induces transcription of the immunomodulatory peptide hormone prolactin. Journal of Inflammation, 12:13.
Tsushima, H., K. Okazaki, K. Ishihara, T. Ushijima and Y. Iwamoto. 2015. CCAAT/enhancer-binding protein β promotes receptor activator of nuclear factor-kappa-B ligand (RANKL) expression and osteoclast formation in the synovium in rheumatoid arthritis. Arthritis Res & Ther, 17:31.
Yoshioka, R.0, Y. Kita, A. Nagahira, A. Manno, N. Makita, U. Tomita, and M. Murakawa. 2015. Quantitative analysis of cadherin-11 and β-catenin signalling during proliferation of rheumatoid arthritis-derived synovial fibroblast cells. Journal of Pharmacy and Pharmacology, 18 March.
Zhang, W., Z. Du, J. Zhu, J. Yu and Y. Xu. 2015. Sprouty2 suppresses the inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes through regulating the Raf/ERK and PTEN/AKT signals. Molec Immunol, 67:532-539.
Zhang, Y. and B. Zhang. 2015. Trichostatin A, an Inhibitor of Histone Deacetylase, Inhibits the Viability and Invasiveness of Hypoxic Rheumatoid Arthritis Fibroblast-Like Synoviocytes via PI3K/Akt Signaling. J Biochem Mol Toxicol, 30:163-169. HFLS-RA
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Hashizume, M. and M. Mihara. 2014. Combination of High-Molecular-Weight Hyaluronic Acid and Cytokine Inhibitor Potently Inhibits Expression of Joint-Damage-Related Genes Induced By Synovial Fluid of RA Patients. J Arthritis, 3:1.
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Wang, H., H. Wang, S. Huang, H. Zhao, Y. Cao, G. Wang, D. Wang, Z. Wang, and Y. Liu. 2014. Inhibitory effect of baicalin on collagen-induced arthritis in rats through the nuclear factor–κB pathway. JPET 350:435-443.
Chiu, W.-C., C.-M. Chen, T.-T. Cheng, H.-L. You, S.-F. Yu, L.-H. Weng, H.-Y. Huang, C.-C. Huang, and C.-J. Chen. 2013. EBV-encoded small RNA1 and nonresolving inflammation in rheumatoid arthritis. The Kaohsiung Journal of Medical Sciences. 29:606-610.
Fan, C., D. Rajasekaran, M.A. Syed, L. Leng, J.P. Loria, V. Bhandari, R. Bucala, and E.J. Lolis. 2013. MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations. Proceedings of the National Academy of Sciences. 110:10994-10999.
Lahoti, T.S., K. John, J.M. Hughes, A. Kusnadi, I.A. Murray, G. Krishnegowda, S. Amin, and G.H. Perdew. 2013. Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signalling in primary human fibroblast-like synoviocytes. Annals of the Rheumatic Diseases. 72:1708-1716.
Kong, X., Y. Zhang, C. Liu, W. Guo, X. Li, X. Su, H. Wan, Y. Sun, and N. Lin. 2013. Anti-angiogenic effect of triptolide in rheumatoid arthritis by targeting angiogenic cascade. PloS one. 8:e77513.
Lin, N. 2013. Triptolide Prevents Bone Destruction in the Collagen-Induced Arthritis Model of Rheumatoid Arthritis by Targeting RANKL/RANK/OPG Signal Pathway. Evidence-Based Complem. & Altern. Med. 2013:Article ID 626038.
Liu, C., X. Kong, X. Li, W. Guo, C. Zhang, Y. Sun, X. Su, X. Liu, A. Lu, and N. Lin. 2013. Wen Luo Yin inhibits angiogenesis in collagen-induced arthritis rat model and in vitro. Journal of ethnopharmacology. 149:478-489.
Matsumoto, Y., H. Ichihara, M. Hino, M. Umebayashi, and R. Ueoka. 2013. Therapeutic effects of hybrid liposomes without drugs for rheumatoid arthritis. Drug Delivery:doi:10.3109/10717544.10712013.10869635.
Woo, J., M.P. Vierboom, H. Kwon, D. Chao, S. Ye, J. Li, K. Lin, I. Tang, N.A. Belmar, and T. Hartman. 2013. PDL241, a novel humanized monoclonal antibody, reveals CD319 as a therapeutic target for rheumatoid arthritis. Arthritis research & therapy. 15:R207.
Xu, Z., G. Wu, X. Wei, X. Chen, Y. Wang, and L. Chen. 2013. Celastrol Induced DNA Damage, Cell Cycle Arrest, and Apoptosis in Human Rheumatoid Fibroblast-Like Synovial Cells. Am. Journal of Chinese Medicine. 41:615-628.
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Hsu, J., Y. Gu, S.-L. Tan, S. Narula, J.A. DeMartino, and C. Liao. 2012. Bruton's Tyrosine Kinase mediates platelet receptor-induced generation of microparticles: A potential mechanism for amplification of inflammatory responses in rheumatoid arthritis synovial joints. Immunology letters. 150:97-104.
Matsuyama., Y., H. Okazaki, M. Hoshino, S. Onishi, Y. Kamata, K. Nagatani, T. Nagashima, M. Iwamoto, T. Yoshio, H. Ohto-Ozaki, H. Tamemoto, M. Komine, H. Sekiya, S. Tominaga, and S. Minoto. 2012. Sustained elevation of interleukin-33 in sera and synovial fluids from patients with rheumatoid arthritis non-responsive to anti-tumor necrosis factor: possible association with persistent IL-1β signaling and a poor clinical response. Rheumatology Intl, 5:1397-1401.
Tsuji, F., K. Oh-hashi and K. Kiuchi. 2012. Differential effects of Akt pathway inhibitors on IL-1β-induced protein phosphorylation in human fibroblast-like Synoviocytes. J Receptors & Signal Transd, 32:22-28.
Valge-Archer, V., A. Williams, D. Young, M. Whitters, M. Collins and J. Witek. 2012. Nucleic acids coding for antibodies against human IL-21 receptor and uses therefor. Patent US 8143385 B2.
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Chen, D.P., C.K. Wong, L.S. Tam, E.K. Li, and C.W. Lam. 2011. Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis. Cellular & molecular immunology. 8:469-478.
Chen, D.-P., C.-K. Wong, P.-C. Leung, K.-P. Fung, C.B.-S. Lau, C.-P. Lau, E.K.-M. Li, L.-S. Tam, and C.W.-K. Lam. 2011b. Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-α-activated human fibroblast-like synoviocytes in rheumatoid arthritis. Journal of ethnopharmacology. 137:457-468.
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Venkatesha, S.H., H. Yu, R. Rajaiah, L. Tong, and K.D. Moudgil. 2011. Celastrus-derived celastrol suppresses autoimmune arthritis by modulating antigen-induced cellular and humoral effector responses. Journal of Biological Chemistry. 286:15138-15146.
Baima, E.T., J.A. Guzova, S. Mathialagan, E.E. Nagiec, M.M. Hardy, L.R. Song, S.L. Bonar, R.A. Weinberg, S.R. Selness, S.S. Woodard, J. Chrencik, W.F. Hood, J.F. Schindler, N. Kishore, and G. Mbalaviele. 2010. Novel Insights into the Cellular Mechanisms of the Anti-inflammatory Effects of NF-κB Essential Modulator Binding Domain Peptides. Journal of Biological Chemistry. 285:13498-13506.
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Itoh, Y., N. Hatano, H. Hayashi, K. Onozaki, K. Miyazawa, and K. Muraki. 2009. An environmental sensor, TRPV4 is a novel regulator of intracellular Ca2+ in human synoviocytes. American Journal of Physiology. 297:C1082-C1090.
Konomi, I., Y.I. DANTSUJI, and A. Nagayama. 2009. Characterization of a Persistent Chlamydial Infection and the Role of Toll like Receptors in the IL 6 Secretion in Chlamydia Trachomatis Infected Human Synovial Fibroblasts. Fukuoka Daigaku igaku kiyō. 36:205-214.
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Hashizume, M., N. Hayakawa, and M. Mihara. 2008. IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-α and IL-17. Rheumatology. 47:1635-1640.
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Abe, K., A. Aslam, A.F. Walls, T. Sato, and H. Inoue. 2006. Up-regulation of protease-activated receptor-2 by bFGF in cultured human synovial fibroblasts. Life sciences. 79:898-904.
Lu, J., N. Zhi, S. Wong, and K.E. Brown. 2006. Activation of synoviocytes by the secreted phospholipase A2 motif in the VP1-unique region of parvovirus B19 minor capsid protein. Journal of Infectious Diseases. 193:582-590.
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Perper, S., B. Browning, L. Burkly, S. Weng, C. Gao, K. Giza, L. Su, L. Tarilonte, T. Crowell, L. Rajman, L. Runkel, M. Scott, G. Atkins, D. Findlay, T. Zheng, and H Hess. 2006. TWEAK Is a Novel Arthritogenic Mediator. J Immunol. 15:2610-2620.
Akasaka, Y., K. Abe, T. Sato, and H. Inoue. 2005. Regulation of neurokinin-1 receptor messenger RNA expression in synovial fibroblasts of patients with rheumatoid arthritis. Neuropeptides. 39:467-474.
Keith, J.C., Jr., L.M. Albert, Y. Leathurby, M. Follettie, L. Wang, L. Borges-Marcucci, C.C. Chadwick, R.J. Steffan, and D.C. Harnish. 2005. The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-kappa B transcriptional activity in models of rheumatoid arthritis. Arthritis research & therapy. 7:R427-438.
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Lin, B., J.M. Kidder, R. Noring, A.C. Steere, M.S. Klempner, and L.T. Hu. 2001. Differences in Synovial Fluid Levels of Matrix Metalloproteinases Suggest Separate Mechanisms of Pathogenesis in Lyme Arthritis before and after Antibiotic Treatment. Journal of Infectious Diseases. 184:174-180.
Privat, S.J., A. Oo, and L.D. Waterbury. 2001. Production of interleukin-6, but not interleukin-8, induced by TNF-alpha or IL-1 beta in human fibroblast-like synoviocyte increases over cell passage. Proceedings of the Western Pharmacology Society. 44:9-13.
Yano, K., N. Nakagawa, H. Yasuda, E. Tsuda, and K. Higashio. 2001. Synovial cells from a patient with rheumatoid arthritis produce osteoclastogenesis inhibitory factor/osteoprotegerin: reciprocal regulation of the production by inflammatory cytokines and basic fibroblast growth factor. Journal of bone and mineral metabolism. 19:365-372.