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Product Sheet CP10379
Description
Human Umbilical Vein Endothelial Cells (HUVEC) provide a classic model system to study many aspects of endothelial function and disease, such as normal, abnormal and tumor-associated angiogenesis, oxidative stress, hypoxia and inflammation related pathways in endothelia under normal and pathological conditions, cardiovascular-related complications associated with various diseases, mode of action and cardiovascular protection effects of various compounds, etc. Select HUVEC lots have been tested to demonstrate stimulation-dependent angiogenesis and key endothelial cell signaling pathways (phosphorylation of VEGFR2). More information about pre-screened endothelial cells can be found on the Pre-Screened Endothelial Cell Product Page.
HUVEC from Cell Applications, Inc. have been utilized in numerous research publications, for example, to:
- Understand anti-inflammatory properties of HDL
- Develop scaffolds for tissue engineering
- Characterize endothelial cell response to stress and discover mechanisms that protect mitochondria against oxidative stress
- Demonstrate that prolonged hypoxia induces MMP-1 expression, EC migration and angiogenesis
- Show that Alzheimer’s β-amyloid peptide exhibits anti-angiogenic properties
- Demonstrate for the first time that mature miRNA can control gene expression in a cell where it is neither transcribed nor processed
- Show that abnormal matrix composition characteristic for systemic sclerosis leads to impaired vascular function and angiogenesis
- Discover novel mechanisms of inhibiting tumor angiogenesis and metastasis, by limiting EC migration and proliferation, as well as the expression of growth factors and enzymes
- Develop a bubble lyposome based system that enables therapeutic miRNA delivery
- Demonstrate that commercially used flame retardants cause oxidative stress
- Show that hyperglycemia leads to endothelial dysfunction, partially due to depletion of antioxidants, and that regaining glycemic control normalizes growth factor levels in ischemia and improves perfusion recovery
- Show that inhibition of aldose reductase inhibits migration and formation of capillary-like structures by endothelial cells
- Investigate effects of molecular mobility of the outmost material surfaces on cellular adhesion and organization
- Identify signaling differences in cells cultured on different ECM components.
- Investigate mechanisms of cardiovascular protection exerted by bioactive plant and fungal components
- Show that in low doses coumaric acid and resveratrol provide beneficial effects and protect endothelial cells from reactive oxygen species
- Show that combined treatment with melatonin and atorvastatin reversed damage to EC, partly by reducing free radical generation and lipid peroxidation
- Discover that deferoxamine (DFO), an iron-chelating agent, mitigates deleterious effects of radiation on angiogenesis
- Study the differential effects of wood smoke and diesel exhaust particles, as well as carbon nanotubes on inducing oxidative stress and production of cytokines and adhesion molecules in endothelia
(Click to Enlarge) Human Umbilical Vein Endothelial Cell (HUVEC) are (A), immunolabeled with VEGFR2 antibodies (green, B), stained with EC-specific DiI-Ac-LDL (red, C), and forming vessel-like structures (green) when cultured with HDF in the presence of VEGF. Nuclei are visualized with PI (red, B) or DAPI (blue, D).
Details
Tissue | Healthy human umbilical vein |
QC | No bacteria, yeast, fungi, mycoplasma, virus |
Character | Factor VIII-related Ag, DiI-Ac-LDL uptake. S-HUVEC are select HUVEC lots that have been tested positive for VEGFR2 pathway activation following stimulation by VEGF. |
Bioassay | Attach, spread, proliferate in Growth Med |
Cryovial | 500,000 HUVEC (primary culture) in Bas Med w/ 10% FBS, 10% DMSO |
Kit | Cryovial frozen HUVEC (200-05n), Growth Medium (211-500), Subculture Rgnt Kit (090K) |
Proliferating | Shipped in Tsfr Med, 1st psg (flasks or plates) |
Doublings | At least 16 |
Applications | Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use. |
Products
| Product | Size | CAT.# | Price | Quantity |
|---|---|---|---|---|
| Cryopreserved Human Umbilical Vein Endothelial Cells Total Kit, neonatal: 5x10^5 Cells (Neonatal), Medium & Subculture Reagents (See Details tab for specifics) | Size: 1 Kit | CAT.#: 200K-05n | Price: $452.00 | |
| Cryopreserved Umbilical Vein Endothelial Cells (HUVEC), neonatal: Frozen HUVEC (5x10^5) | Size: 1 Cryovial | CAT.#: 200-05n | Price: $278.00 | |
| Cryopreserved Human Umbilical Vein Endothelial Cells Total Kit, fetal: 5x10^5 Cells (Fetal), Medium & Subculture Reagents (See Details tab for specifics) | Size: 1 Kit | CAT.#: 200K-05f | Price: $524.00 | |
| Cryopreserved Umbilical Vein Endothelial Cells (HUVEC), fetal: Frozen HUVEC (5x10^5) | Size: 1 Cryovial | CAT.#: 200-05f | Price: $350.00 | |
| Cryopreserved Human Umbilical Vein Endothelial Cells, Pooled, Total Kit, neonatal: 5x10^5 Cells (Pooled, Neonatal), Medium & Subculture Reagents (See Details tab for specifics) | Size: 1 Kit | CAT.#: 200pK-05n | Price: $394.00 | |
| Cryopreserved Umbilical Vein Endothelial Cells (P-HUVEC), Pooled, neonatal: Frozen HUVEC, pooled (5x10^5) | Size: 1 Cryovial | CAT.#: 200p-05n | Price: $220.00 | |
| Proliferating Umbilical Vein Endothelial Cells (HUVEC), neonatal: Actively growing, dividing cells in medium | Size: T-25 Flask | CAT.#: 201-25n | Price: $278.00 | |
| Proliferating Umbilical Vein Endothelial Cells (HUVEC), neonatal: Actively growing, dividing cells in medium | Size: T-75 Flask | CAT.#: 201-75n | Price: $468.00 | |
| Proliferating Umbilical Vein Endothelial Cells (HUVEC), neonatal: Actively growing, dividing cells in medium | Size: 96 Well | CAT.#: 201-96Wn | Price: $588.00 | |
| Proliferating Umbilical Vein Endothelial Cells (HUVEC), fetal: Actively growing, dividing cells in medium | Size: T-25 Flask | CAT.#: 201-25f | Price: $350.00 | |
| Proliferating Umbilical Vein Endothelial Cells (HUVEC), fetal: Actively growing, dividing cells in medium | Size: T-75 Flask | CAT.#: 201-75f | Price: $540.00 | |
| Proliferating Umbilical Vein Endothelial Cells (HUVEC), fetal: Actively growing, dividing cells in medium | Size: 96 Well | CAT.#: 201-96Wf | Price: $660.00 | |
| Proliferating Umbilical Vein Endothelial Cells (P-HUVEC), Pooled, neonatal: Actively growing, dividing cells in medium | Size: T-25 Flask | CAT.#: 201p-25n | Price: $220.00 | |
| Proliferating Umbilical Vein Endothelial Cells (P-HUVEC), Pooled, neonatal: Actively growing, dividing cells in medium | Size: T-75 Flask | CAT.#: 201p-75n | Price: $410.00 | |
| Proliferating Umbilical Vein Endothelial Cells (P-HUVEC), Pooled, neonatal: Actively growing, dividing cells in medium, pooled | Size: 96 Well | CAT.#: 201p-96Wn | Price: $530.00 | |
| Cryopreserved Pre-Screened Cryopreserved S-HUVEC Total Kit, neonatal: 5x10^5 Cells (Pre-Screened, Neonatal), Medium & Subculture Reagents (See Details tab for specifics) | Size: 1 Kit | CAT.#: S200K-05n | Price: $619.00 | |
| Cryopreserved Umbilical Vein Endothelial Cells (HUVEC), Pre-Screened, neonatal : Frozen HUVEC (5x10^5) | Size: 1 Cryovial | CAT.#: S200-05n | Price: $445.00 | |
| Proliferating Umbilical Vein Endothelial Cells (S-HUVEC), Pre-Screened, neonatal: Actively growing, dividing cells in medium | Size: T-25 Flask | CAT.#: S201-25n | Price: $445.00 | |
| Proliferating Umbilical Vein Endothelial Cells (S-HUVEC), Pre-Screened, neonatal: Actively growing, dividing cells in medium | Size: T-75 Flask | CAT.#: S201-75n | Price: $635.00 | |
| Proliferating Umbilical Vein Endothelial Cells (S-HUVEC), Pre-Screened, neonatal: Actively growing, dividing cells in medium | Size: 96 Well | CAT.#: S201-96Wn | Price: $755.00 |
Related Products
| Product | Size | CAT.# | Price | Quantity |
|---|---|---|---|---|
| Human EC Growth Medium: All-in-one ready-to-use. Optimized and best-suited for angiogenesis and other physiological studies. For accelerated growth, use Cat# 213-500. | Size: 500 ml | CAT.#: 211-500 | Price: $121.00 | |
| Human EC Growth Medium Kit: Basal medium & growth supplement sold together packaged separately. Optimized and best-suited for angiogenesis and other physiological studies. For accelerated growth, use Cat# 213-500. | Size: Yields 500 ml | CAT.#: 211K-500 | Price: $143.00 | |
| Human EC Basal Medium: Basal medium (contains no growth supplement). Add GS before use. | Size: 500 ml | CAT.#: 210-500 | Price: $91.00 | |
| Human EC Growth Supplement: Added to Basal Medium to create Growth Medium. The complete Growth Medium (equivalent to Cat# 211-500) is optimized and best-suited for angiogenesis and other physiological studies. For accelerated growth, use Cat# 213-500. | Size: 15 ml | CAT.#: 211-GS | Price: $74.00 | |
| Human EC Growth Medium V2: All-in-one ready-to-use. Enriched with more growth factors for accelerated cell growth. For angiogenesis studies, use Cat# 211-500. | Size: 500 ml | CAT.#: 213-500 | Price: $141.00 | |
| Endothelial Cells Growth Medium V2 Kit, 500ml: Basal medium & growth supplement sold together packaged separately. Enriched with more growth factors for accelerated cell growth. For angiogenesis studies, use Cat# 211K-500. | Size: 500 ml | CAT.#: 213K-500 | Price: $144.00 | |
| Human EC Serum-Free Defined Medium: Defined medium without serum designed to maintain endothelial cell monlayers in confluent cultures. Not for cell growth. | Size: 500 ml | CAT.#: 113-500 | Price: $130.00 | |
| Human EC Starvation Medium: Use when cells need to be starved overnight to 24 hrs before experiment | Size: 250 ml | CAT.#: 209-250 | Price: $81.00 | |
| Human EC Growth Medium wo Phenol Red: Growth medium without phenol red. Optimized and best-suited for angiogenesis and other physiological studies. For accelerated growth, use Cat# 213-500. | Size: 500 ml | CAT.#: 211PR-500 | Price: $130.00 | |
| Human EC Growth Medium wo FBS: 211-500 growth medium, but without FBS. FBS must be added in order to support cell culture. | Size: 500 ml | CAT.#: 211F-500 | Price: $130.00 | |
| Human EC Growth Medium wo Antibiotics: Growth medium without antibiotics. Optimized and best-suited for angiogenesis and other physiological studies. Suitable for Cytofect Transfection Kit. For accelerated growth, use Cat# 213-500. | Size: 500 ml | CAT.#: 211A-500 | Price: $130.00 | |
| Human EC Growth Medium wo Hydrocortisone: Growth medium without hydrocortisone. The complete Growth Medium is optimized and best-suited for angiogenesis and other physiological studies. For accelerated growth, use Cat# 213-500. | Size: 500 ml | CAT.#: 211H-500 | Price: $130.00 | |
| Human EC Growth Supplement wo FBS: Growth supplement without FBS. FBS must be added in order to support cell culture. | Size: 5 ml | CAT.#: 211F-GS | Price: $91.00 | |
| Human EC Growth Medium Kit V2, components separate: Basal medium & growth supplement sold together packaged separately. Supplements in individual vials. Enriched with more growth factors for accelerated cell growth. For angiogenesis studies, use Cat# 211K-500. | Size: 500 ml | CAT.#: 213KS-500 | Price: $155.00 | |
| Human EC Growth Supplement wo Antibiotics: Growth supplement without antibiotics | Size: 15 ml | CAT.#: 211A-GS | Price: $88.00 | |
| Human EC Growth Supplement wo Hydrocortisone: Growth supplement without hydrocortisone | Size: 15 ml | CAT.#: 211H-GS | Price: $88.00 | |
| Human EC Serum-Free Defined Medium wo Phenol Red: Defined medium, without serum or phenol red, designed to maintain endothelial cell monlayers in 100% confluent culture. Not intended for cell growth. | Size: 500 ml | CAT.#: 113PR-500 | Price: $136.00 | |
| Human EC Starvation Medium wo Phenol Red: Starvation medium without phenol red | Size: 250 ml | CAT.#: 209PR-250 | Price: $91.00 | |
| HUVEC Conditioned Medium: HUVEC Conditioned Medium | Size: 5 ml | CAT.#: 211CM-05 | Price: $55.00 |
Extended Family Products
| Product | Size | CAT.# | Price | Quantity |
|---|---|---|---|---|
| Anti-ICAM-1: Rabbit Intercellular Adhesion Molecule-1 Antibody | Size: 100 ul | CAT.#: CG1238 | Price: $275.00 | |
| Freezing Medium: For general cryopreservation of most primary cells. Contains FBS & DMSO. | Size: 50 ml | CAT.#: 040-50 | Price: $54.00 | |
| Cyto-X Cell Counting Reagent Sample: 100 tests | Size: Sample | CAT.#: 028-S | Price: $41.00 | |
| Cyto-X Cell Counting Reagent: 500 tests | Size: 1 Bottle | CAT.#: 028-01 | Price: $160.00 | |
| Cytofect HUVEC Transfection Kit (250 x 24-Wells): 250 x 24-Well Rxns | Size: 1 Kit | CAT.#: TF200K | Price: $328.00 | |
| Cytofect HUVEC Transfection Sample Kit (25 x 24-Wells): 25 x 24-Well Rxns | Size: 1 Sample Kit | CAT.#: TF200KS | Price: $62.00 | |
| Human E-Selectin ELISA Kit: Human E-Selectin ELISA Kit | Size: 96 Wells | CAT.#: CL0501 | Price: $587.00 | |
| Umbilical Vein Endothelial Cell RNA (HUVEC RNA), Stimulated RNA, Neonatal: Total RNA prepared from Human Umbilical Vein Endothelial Cells, Stimulated, neonatal | Size: 10 ug | CAT.#: 200S-R10n | Price: $465.00 | |
| Umbilical Vein Endothelial Cell RNA (HUVEC RNA), Stimulated RNA, Neonatal: Total RNA prepared from Human Umbilical Vein Endothelial Cells, Stimulated, neonatal | Size: 25 ug | CAT.#: 200S-R25n | Price: $930.00 | |
| Umbilical Vein Endothelial Cell RNA (HUVEC RNA), Neonatal: Total RNA prepared from Human Umbilical Vein Endothelial Cells, neonatal | Size: 10 ug | CAT.#: 200-R10n | Price: $398.00 | |
| Umbilical Vein Endothelial Cell RNA (HUVEC RNA), Neonatal: Total RNA prepared from Human Umbilical Vein Endothelial Cells, neonatal | Size: 25 ug | CAT.#: 200-R25n | Price: $796.00 | |
| Human ICAM-1 ELISA Kit: Human Intercellular Adhesion Molecule-1 ELISA Kit | Size: 96 Wells | CAT.#: CL0370 | Price: $484.00 | |
| Human Gamma-Interferon Inducible Protein 10 (IP-10 / CXCL10): Human gamma-Interferon Inducible Protein 10 | Size: 25 ug | CAT.#: RP1127-25 | Price: $194.00 | |
| Human Gamma-Interferon Inducible Protein 10 (IP-10 / CXCL10): Human gamma-Interferon Inducible Protein 10 | Size: 100 ug | CAT.#: RP1127-100 | Price: $484.00 | |
| Human Gamma-Interferon Inducible Protein 10 (IP-10 / CXCL10): Human gamma-Interferon Inducible Protein 10 | Size: 1000 ug | CAT.#: RP1127-1000 | Price: $3,175.00 | |
| Human P-Selectin ELISA Kit: Human P-Selectin ELISA Kit | Size: 96 wells | CAT.#: CL0505 | Price: $517.00 | |
| Subculture Reagent Kit: 100 ml each of HBSS, Trypsin/EDTA & Trypsin Neutralizing Solution | Size: 1 Kit | CAT.#: 090K | Price: $63.00 |
Resources/Documents
Citations
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2017
Chen, L., Okeke, E., Ayalew, D., Wang, D., Shahid, L. and Dokun, A.O., 2017. Modulation of miR29a improves impaired post-ischemic angiogenesis in hyperglycemia. Experimental Biology and Medicine, p.1535370217716424.
Goszcz, K., Deakin, S., Duthie, G. G., Stewart, D., Megson, I. L., & Megson, I. L. 2017. Bioavailable concentrations of delphinidin and its metabolite, gallic acid, induce antioxidant protection associated with increased intracellular glutathione in cultured endothelial cells. Oxidative Medicine and Cellular Longevity.
Sagara, A., T. Karasawa, K. Igarashi, M. Otsuka, R. Sugiura, A. Kodama, M. Yamashita, N. Narita and Y. Kato. 2017. Controlled Secretion of the Anticancer Protein MDA-7 from Engineered Mesenchymal Stem Cells. Biol & Pharm Bull, 40:113-117.
Shamini, N., A. Michelsen, P. Nilsson, K. Ekholt, L. Gullestad, K. Broch, C. Dahl, P. Aukrust, T. Ueand, T. Mollnes, A. Yndestad & M. Louwe. The alternative complement pathway is dysregulated in patients with chronic heart failure. Scientific Reports, 7, 42532.
Szymiczek, A., S. Pastorino, D. Larson, M. Tanji, L. Pellegrini, J. Xue, S. Li, C. Giorgi, P. Pinton, Y. Takinishi, H. Pass, H. Furuya, G. Gaudino, A. Napolitan, M. Carbone and H. Yang. 2017. FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model. J Translational Med, 15:58.
Zhao, G., X. Cheng, L. Piao, L. Hu, Y. Lei, G. Yang, A. Inoue, S. Ogasawara, H. Wu, N. Hao, K. Okumara and M. Kuzuya. 2016. The Soluble VEGF Receptor sFlt-1 Contributes to Impaired Neovascularization in Aged Mice. Aging and Disease, 8(3), June 2017.
2016
Cao, Y., M. Roursgaard, N. Jacobsen, P. Møller and S. Loft. 2016. Monocyte adhesion induced by multi-walled carbon nanotubes and palmitic acid in endothelial cells and alveolar–endothelial co-cultures. 235-244.
Ganta, V., M. Choi, A. Kutateladze and B. Annex. 2016. VEGF165b Modulates Endothelial VEGFR1-STAT3 Signaling Pathway and Angiogenesis in Human and Experimental Peripheral Arterial Disease. Circulation Research, DOI: 10.1161/CIRCRESAHA.116.309516.
Jia, P., H. Chen, H. Kang, J. Qi, P. Zhao, M. Jiang, L. Guo, Q. Zhou, N. Qian, H. Zhou, Y. Xu, Y. Fan and L. Deng. 2016. Deferoxamine released from poly(lactic-co-glycolic acid) promotes healing of osteoporotic bone defect via enhanced angiogenesis and osteogenesis. J Biomed Mat Res 104:2515-2527.
Lansford, K., D. Shill, A. Dicks, M. Marshburn, W. Southern. And N. Jenkins. 2016. Effect of acute exercise on circulating angiogenic cell and microparticle populations. Experimental Physiology, 101:155-167.
Pink, A., M. Skolnaja, T. Paell and A. Valkna. 2016. CD44 Controls Endothelial Proliferation and Functions as Endogenous Inhibitor of Angiogenesis. bioRxiv, dx.doi.org/10.1101/049494.
Priest, J., K. Osoegawa, N. Mohammed, V. Nanda, R.l Kundu, K. Schultz, E. Lammer, S. Girirajan, T. Scheetz, D. Waggott, F. Haddad, S. Reddy, D. Bernstein, T. Burns, J. Steimle, X. Yang, I. Moskowitz, M. Hurles, R. Lifton, D. Nickerson, M. Bamshad, E. Eichler, S. Mital, V. Sheffield, T. Quertermous, B. Gelb, M. Portman and E. Ashley. 2016. De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects. PLoS Genet 12(4): e1005963.
Roshan, A., L. Dong, C. Alvan, J. Bart and H. Wenhu. 2016. Validation of Cross-Species Reactivity of the VEGF-A/PDGFRβ Bifunctional Antibody PF-06653157. J Ocular Pharmacol & Ther, doi:10.1089/jop.2016.0027.
Savoji, H., M. Maire, P. Lequoy, B. Liberelle, G. De Crescenzo, A. Ajji, M. Wertheimer and S. Lerouge. 2016. Combining electrospun fiber mats and bioactive coatings for vascular graft prostheses. Biomacromolecules, DOI: 10.1021/acs.biomac.6b01770
Shi, L., A. Kim, R. Chang, J. Chang, W. Ying, M. Ko, B. Zhou and G. Ko. 2016. Deletion of miR-150 Exacerbates Retinal Vascular Overgrowth in High-Fat-Diet Induced Diabetic Mice. PLoS ONE, 11(6): e0157543.
Wang, S., R. Yang, M. Chang, T. Lu, and L. Tsao. 2016. Effect of Heat Shock Treatment on Endothelial Cell Integrity after Histamine Challenge. The Changhua Journal of Medicine, 14:1-11.
2015
Annex, B., C. Farber, and S. Hazarika. 2015. COMPOSITIONS AND METHODS FOR TREATING PERIPHERAL ARTERIAL DISEASE. Patent Application US 20150218556 A1.
Basudhara, D., R. Chengb, G. Bharadwaja, L. Ridnourb, D. Winkb, and K. Mirandaa. 2015. Chemotherapeutic potential of diazeniumdiolate-based aspirin prodrugs in breast Cancer. Free Radical Biology and Medicine, 4 February.
Berg, E., M. Polokoff, A. O’Mahony, D. Nguyen, and X Li. 2015. Elucidating Mechanisms of Toxicity Using Phenotypic Data from Primary Human Cell Systems—A Chemical Biology Approach for Thrombosis-Related Side Effects. International, Journal of Molecular Sciences, 16:1008-1029.
Boire, T., M. Gupta, A. Zachman, S. Lee, D. Balikov, K. Kim, L. Bellan, and H. Sung. 2015. Pendant Allyl Crosslinking as a Tunable Shape Memory Actuator for Vascular Applications. Acta Biomaterialia, doi:10.1016/j.actbio.2015.06.004.
Danielsen, P., Y. Cao, M. Roursgaard, P. Møller & S. Loft. 2015. Endothelial cell activation, oxidative stress and inflammation induced by a panel of metal-based nanomaterials. Nanotoxicology 9:813-824.
Devapatla, B., A. Sharma and S. Woo. 2015. CXCR2 Inhibition Combined with Sorafenib Improved Antitumor and Antiangiogenic Response in Preclinical Models of Ovarian Cancer. PLoS ONE 10(9): e0139237.
Dokun, A., L. Chen, M. Okutsu, C. Farber, S. Hazarika, W. Jones, D. Craig, D. Marchuk, J. Lye, S. Shan, and B. Annex. 2015. ADAM12: A Genetic Modifier of Pre-clinical Peripheral Arterial Disease. Am J Physiol, DOI: 10.1152/ajpheart.00803.2014.
Flebus, L., F. Lombart, C. Sevrin, J. Defraigne, P. Peters, L. Parhamifar, D. Molin and C. Grandfils. 2015. Low molecular weight poly (2-dimethylamino ethylmethacrylate) polymers with controlled positioned fluorescent labeling: Synthesis, characterization and in vitro interaction with human endothelial cells. Int J Pharmaceutics, 478:278-287.
Gaston, B., A. Straub, B. Isakson, and L. Columbus. 2015.Compositions and Methods for Regulating Arterial Tone. Patent Application US 20150274779 A1.
Huang, B., J. Cheng, C. Wu, P. Chen, P. Tu, Y. Fu, and C. Wu. 2015. Camptothecin promotes the production of nitric oxide that triggers subsequent S-nitrosoproteome-mediated signaling cascades in endothelial cells. Vascular Pharmacol, doi:10.1016/j.vph.2015.07.014.
Izaguirre-Carbonell, J., H. Kawakubo, H. Murata, A. Tanabe, T. Takeuchi, T. Kusayanagi, S. Tsukuda, T. Hirakawa, K. Iwabata, Y. Kanai, K. Ohta, M. Miura, K. Sakaguchi, S. Matsunaga, H. Sahara, S. Kamisuki and F. Sugawara. 2015. Novel anticancer agent, SQAP, binds to focal adhesion kinase and modulates its activity. Sci Rep, 5:15136.
Kawasaki, Y., E. Yokobayashi, K. Sakamoto, E. Tenma, H. Takaki, Y. Chiba, T. Otashiro, M. Ishihara, S. Yonezawa, A. Sugiyama and Y. Natori. 2015. Angiostatin prevents IL-1β-induced down-regulation of eNOS expression by inhibiting the NF-κB cascade. J Pharmacolog Sci, 129:200-204.
Kim, K., Y. Lee, H. Ji, R. Song, J. Kim, S. Lee, S. Hong, M. Yoo, and H. Yang. 2015. Increased expression of endocan in arthritic synovial tissues: Effects of adiponectin on the expression of endocan in fibroblast-like synoviocytes. Molecular Medicine Reports, 11:2695-2702.
Klingberg, H., L. Oddershede, K. Loeschner, E. Larsen, S. Lofta, and Møller. 2015. Uptake of gold nanoparticles in primary human endothelial cells. Toxicology Research, 4:655-666.
Kobayashi, M., T. Kawase, K. Okuda, AL. Wolff and H. Yoshie. 2015. In vitro immunological and biological evaluations of the angiogenic potential of platelet-rich fibrin preparations: a standardized comparison with PRP preparations. Intl J Implant Dentistry, 1:31.
Lansford, K., D. Shill, A. Dicks, M. Marshburn, W. Southern. And N. Jenkins. 2015. Effect of acute exercise on circulating angiogenic cell and microparticle populations. Experimental Physiology, doi: 10.1113/EP085505.
Li, X., X. Cheng, L. Hu, H. Wu, G. Ping, C. Hao, H. Jiang, E. Zhu, Z. Huang, A. Inoue, T. Sasaki, Q. Du, K. Takeshita, K. Okumura, T. Murohara and M. Kuzuya. 2015. Cathepsin S activity controls ischemia-induced neovascularization in mice. Intl J Cardiol, 183:198-208.
Liu, Y., Q. Chen, M. Xu, G. Guan, W. Hu, Y. Liang, X. Zhao, M. Qiao, D. Chen, and H. Liu. 2015. Single peptide ligand-functionalized uniform hollow mesoporous silica nanoparticles achieving dual-targeting drug delivery to tumor cells and angiogenic blood vessel cells. International Journal of Nanomedicine, 10:1855-1867.
Liu, G., B. Liang, W. Lau, Y. Wang, J. Zhao, R. Li, X. Wang, Y. Yuan, B. Lopez, T. Christopher, C. Xiao, X. Ma and Y. Wang. 2015. High glucose/High Lipids impair vascular adiponectin function via inhibition of caveolin-1/AdipoR1 signalsome formation. Free Radical Biol & Med, 89:473-485.
Madasamy, S. 2015. Multi-subunit biological complexes for treatment of plaque-associated diseases. Patent US8932558B2.
Nishitani, W., A. Alencar and Y. Wang. 2015. Rapid and Localized Mechanical Stimulation and Adhesion Assay: TRPM7 Involvement in Calcium Signaling and Cell Adhesion. PLoS ONE, 10(5): e0126440.
Ramcharan, K. 2015. The Endotheliome and the Angiome in Colorectal Cancer.MD Thesis, U Birmingham.
Tochikubo, J., N. Matsuda, Y. Ota, T. Higashi, Y. Takatani, M. Inaba, Y. Adachi, and N. Shiiya. 2015. Detection of Inflammatory Circulating Endothelial Cells Using Human Umbilical Vein Endothelial Cells Detached from Culture Dishes by Tumor Necrosis Factor-alpha as Control Cells. Cardiol Pharmacol, 4:129.
Ukaji, T., Y. Lin, K. Banno, S. Okada, and K. Umezawa. 2015. Inhibition of IGF-1-Mediated Cellular Migration and Invasion by Migracin A in Ovarian Clear Cell Carcinoma Cells. PLOS One, DOI: 10.1371/journal.pone.0137663.
Yin, Y., H. Liu, F. Wang, L. Li, M. Deng, L. Huang and X. Zhao. 2015. Transplantation of cryopreserved human umbilical cord blood-derived endothelial progenitor cells induces recovery of carotid artery injury in nude rats. Stem Cell Res & Ther, 6:37.
Zhu, D., H. Wang, J. Zhang, X. Zhang, C. Xin, F. Zhang, Y. Lee, L. Zhang, K. Lian, W. Yan, X. Ma, Y. Lu and L. Tao. 2015. Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nitrative stresses. J Molec & Cell Cardiol, 87:138-147.
2014
Cao, Y., N. Jacobsen, P. Danielsen, A. Lenz, T. Stoeger, S. Loft, H. Wallin, M. Roursgaard, L. Mikkelsen and P. Møller. 2014. Vascular Effects of Multiwalled Carbon Nanotubes in Dyslipidemic ApoE−/− Mice and Cultured Endothelial Cells. Toxicol Sci, 138:104-116.
Cao, Y., M. Roursgaard, P. Danielsen, P. Møller and S. Loft. 2014. Carbon Black Nanoparticles Promote Endothelial Activation and Lipid Accumulation in Macrophages Independently of Intracellular ROS Production. PLoS ONE, dx.doi.org/10.1371/journal.pone.0106711.
Cha, B., H. Kwak, A. Park, S. Kim, S. Park, H. Kim, I. Kim, K. Lee, and Y. Park. 2014. Structural characteristics and biological performance of silk fibroin nanofiber containing microalgae spirulina extract. Biopolymers, 101:307-318.
Dokun, A. L. Chen, S. Lanjewar, J. Lye, and B. Annex. 2014. Glycemic Control Improves Perfusion Recovery and VEGFR2 Protein Expression in Diabetic Mice Following Experimental PAD. Cardiovascular Research, 101:364-372.
Endo-Takahashi, Y., Y. Negishi, A. Nakamura, S. Ukai, K. Ooaku, Y. Oda, K. Sugimoto, F. Moriyasu, N. Takagi, R. Suzuki, K. Maruyama, and Y. Aramaki. 2014. Systemic delivery of miR-126 by miRNA-loaded Bubble liposomes for the treatment of hindlimb ischemia. Scientific Reports 4, Article number: 3883.
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2013
Cha, B.G., H.W. Kwak, A.R. Park, S.H. Kim, S.Y. Park, H.J. Kim, I.S. Kim, K.H. Lee, and Y.H. Park. 2013. Structural characteristics and biological performance of silk fibroin nanofiber containing microalgae spirulina extract 6. Peptide Science:DOI: 10.1002/bip.22359.
Chen, Z., T.C. Lai, Y.H. Jan, F.M. Lin, W.C. Wang, H. Xiao, Y.T. Wang, W. Sun, X. Cui, Y.S. Li, T. Fang, H. Zhao, C. Padmanabhan, R. Sun, D.L. Wang, H. Jin, G.Y. Chau, H.D. Huang, M. Hsiao, and J.Y.J. Shyy. 2013. Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis. The Journal of clinical investigation. 123:1057-1067.
Kaakinen, M., S. Huttunen, L. Paavolainen, V. MarjomÄKi, J. HeikkilÄ, and L. Eklund. 2013. Automatic detection and analysis of cell motility in phase-contrast time-lapse images using a combination of maximally stable extremal regions and Kalman filter approaches. Journal of Microscopy. 253:65-78.
Lohr, N.L., J.T. Ninomiya, D.C. Warltier, and D.e. Weihrauch. 2013. Far red/near infrared light treatment promotes femoral artery collateralization in the ischemic hindlimb 2. Journal of Molecular and Cellular Cardiology. 62:36-42.
Mazor, R., T. Alsaigh, H. Shaked, A.E. Altshuler, E.S. Pocock, E.B. Kistler, M. Karin, and G.W. Schmid-Sch+Ýnbein. 2013. Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells. The Journal of biological chemistry. 288:598-607.
Nakayama, K. 2013a. cAMP-response Element-binding Protein (CREB) and NF-κB Transcription Factors Are Activated during Prolonged Hypoxia and Cooperatively Regulate the Induction of Matrix Metalloproteinase MMP1. Journal of Biological Chemistry. 288:22584-22595.
Nakayama, K. 2013b. CREB and NF-κB are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1. Journal of Biological Chemistry. 288:22584-22589.
Pallet, N., I. Sirois, C. Bell, L.l.A.c. Hanafi, K. Hamelin, M. Dieud+ª, C. Rondeau, P. Thibault, M. Desjardins, and M.J.e. Hebert. 2013. A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells 7. PROTEOMICS. 13:1108-1120.
Takizawa, Y., Y. Kosuge, H. Awaji, E. Tamura, A. Takai, T. Yanai, R. Yamamoto, K. Kokame, T. Miyata, and R. Nakata. 2013. Up-regulation of endothelial nitric oxide synthase (eNOS), silent mating type information regulation 2 homologue 1 (SIRT1) and autophagy-related genes by repeated treatments with resveratrol in human umbilical vein endothelial cells. The British journal of nutrition:1-6.
Tseng, A.H.H., S.-S. Shieh, and D.L. Wang. 2013. SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage. Free Radical Biology and Medicine. 63:222-234.
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Whitsett, J., A. Rangel Filho, S. Sethumadhavan, J. Celinska, M. Widlansky, and J. Vasquez-Vivar. 2013. Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling. Free Radical Biology and Medicine. 63:143-150.
2012
Bernson, E. 2012. Development of a Microfluidic Platform for Cell migration Studies along Gradients. In Department of Applied Physics. MS Thesis, Chalmers University of Technology.
Cossu, A. 2012. Study of intracellular signaling pathways triggered by natural antioxidants in human endothelial cells. Doctoral Thesis, Università degli studi di Sassari.
Ding, S., D.M. Pinkas, and A.E. Barron. 2012. Synthesis and assembly of functional high molecular weight adiponectin multimers in an engineered strain of Escherichia coli. Biomacromolecules. 13:1035-1042.
Donneys, A., D.M. Weiss, S.S. Deshpande, S. Ahsan, C.N. Tchanque-Fossuo, D. Sarhaddi, B. Levi, S.A. Goldstein, and S.R. Buchman. 2012. Localized deferoxamine injection augments vascularity and improves bony union in pathologic fracture healing after radiotherapy. Bone. 52:318–325.
Forchhammer, L., S. Loft, M. Roursgaard, Y. Cao, I.S. Riddervold, T. Sigsgaard, and P. Møller. 2012. Expression of adhesion molecules, monocyte interactions and oxidative stress in human endothelial cells exposed to wood smoke and diesel exhaust particulate matter. Toxicology letters. 209:121-128.
Giedt, R., D. Pfeiffer, A. Matzavinos, C. Kao and B. Alevriadou. 2012. Mitochondrial Dynamics and Motility Inside Living Vascular Endothelial Cells: Role of Bioenergetics. Annals of Biomed Eng, 40:1903-1916.
Giedt, R., C. Yang, J. Zweier, A. Matzavinos and B. Alevriadou. 2012. Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species. Free Rad Biol & Med, 52:348-356.
Hisano, Y., N. Kobayashi, A. Yamaguchi, and T. Nishi. 2012. Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells. PloS one. 7:e38941.
Jacky, B., P. Garay, Y. Molina, J. Francis, L. Steward, S. Ghanshani, T. Hunt, K. Aoki, and E. Fernandez-Salas. 2012. Inhibiting Aberrant Blood Vessel Formation Using Growth Factor Retargeted Endopeptidases. Patent Applications US 20120207704 A1.
Jacky, B., P. Garay, Y. Molina, J. Francis, L. Steward, S. Ghanshani, T. Hunt, K. Aoki, and E. Fernandez-Salas. 2012. Treating a Disease of Hyperproliferation Using Retargeted Endopeptidases. Patent Application US 20120207733 A1.
Jacky, B., P. Garay, Y. Molina, J. Francis, L. Steward, S. Ghanshani, T. Hunt, K. Aoki, and E. Fernandez-Salas. 2012. Methods of Inhibiting Aberrant Blood Vessel Formation Using Opioid Retargeted Endpeptidases. Patent Application US 20120207734 A1.
Jacky, B., P. Garay, Y. Molina, J. Francis, L. Steward, S. Ghanshani, T. Hunt, G. Sachs, K. Aoki, and E. Fernandez-Salas. 2012. Treatments Using PSMA Ligand Endopeptidases. US 20120207742 A1.
Kawaguchi, K., F. Lambein and K. Kusama-Eguchi. 2012. Vascular insult accompanied by overexpressed heme oxygenase-1 as a pathophysiological mechanism in experimental neurolathyrism with hind-leg paraparesis. BBRC, 428:160-166.
Murai, A., S. Asa, A. Kodama, A. Hirata, T. Yanai, and H. Sakai. 2012. Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines. BMC Veterinary Research. 8:128.
Nakamura, D., A. Edwards, S. Virani, R. Thomas and C. Tayade. 2012. Thrombospondin-1 Mimetic Peptide ABT-898 Affects Neovascularization and Survival of Human Endometriotic Lesions in a Mouse Model. Am J Pathol, 181:570-582.
Siegel, D., J. Kepa and D. Ross. 2012. NAD(P)H:Quinone Oxidoreductase 1 (NQO1) Localizes to the Mitotic Spindle in Human Cells. PLoS ONE, dx.doi.org/10.1371/journal.pone.0044861.
Namin, S.M. 2012. An Experimental and Theoretical Analysis of Nitric Oxide in the Microcirculation. PhD Dissertation, Florida International University.
Paolillo, R., M. Lovene, C. Carratelli, and A. Rizzo. 2012. Induction of VEGF and MMP-9 Expression by Toll-like Receptor 2/4 in Human Endothelial Cells Infected with Chlamydia Pneumoniae. Intl J Immunopathol & Pharmacol, 25:377-386.
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Siegel, D., J.K. Kepa, and D. Ross. 2012. NAD(P)H:Quinone Oxidoreductase 1 (NQO1) Localizes to the Mitotic Spindle in Human Cells 1. PloS one. 7:e44861.
Shao, M., S. Hollar, D. Chambliss, J. Schmitt, R. Emerson, B. Chelladurai, S. Perkins, M. Ivan, and D. Matei. 2012. Targeting the Insulin Growth Factor and the Vascular Endothelial Growth Factor Pathways in Ovarian Cancer. Molecular Cancer Therapeutics. 11:1576-1586.
Suzuki, K., R. Hayashi, T. Ichikawa, S. Imanishi, T. Yamada, M. Inomata, T. Miwa, S. Matsui, I. Usui, M. Urakaze, Y. Matsuya, H. Ogawa, H. Sakurai, I. Saiki and K. Tobe. 2012. SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice. Oncology Reports, 27:1726-1732.
Takino, J., S. Yamagishi, and M. Takeuchi. 2012. Glycer-AGEs-RAGE signaling enhances the angiogenic potential of hepatocellular carcinoma by upregulating VEGF expression. World journal of gastroenterology: WJG. 18:1781.
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Xie, W., Z. Zhi, Y. Yang, T. Kuang and C. Wang. 2012. Free fatty acids inhibit TM–EPCR expression through JNK pathway: an implication for the development of the prothrombotic state in metabolic syndrome. J Thrombosis & Thrombolysis, 34:468-474.
2011
Dayoub, J.C., F. Ortiz, L.C. L+Ýpez, C. Venegas, A. del Pino-Zumaquero, O. Roda, I. S+¡nchez-Montesinos, D.o. Acu+Ýa-Castroviejo, and G. Escames. 2011. Synergism between melatonin and atorvastatin against endothelial cell damage induced by lipopolysaccharide 9. Journal of Pineal Research. 51:324-330.
Jane, E.P., D.R. Premkumar, and I.F. Pollack. 2011. Bortezomib Sensitizes Malignant Human Glioma Cells to TRAIL, Mediated by Inhibition of the NF-κB Signaling Pathway. Molecular Cancer Therapeutics. 10:198-208.
Konakahara, S., M. Saitou, S. Hori, T. Nakane, K. Murai, R. Itoh, A. Shinsaka, J. Kohroki, T. Kawakami, M. Kajikawa, and Y. Masuho. 2011. A neuronal transmembrane protein LRFN4 induces monocyte/macrophage migration via actin cytoskeleton reorganization. FEBS letters. 585:2377-2384.
Mehta, R.R., T. Yamada, B.N. Taylor, K. Christov, M.L. King, D. Majumdar, F. Lekmine, C. Tiruppathi, A. Shilkaitis, and L. Bratescu. 2011. A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt. Angiogenesis. 14:355-369.
Mikkelsen, L., M. Sheykhzade, K.A. Jensen, A.T. Saber, N.R. Jacobsen, U. Vogel, H. Wallin, S. Loft, and P. Moller. 2011. Modest effect on plaque progression and vasodilatory function in atherosclerosis-prone mice exposed to nanosized TiO2. Part Fibre Toxicol. 8:32.
Mukai, R., H. Ashida, J. Terao, and N. Saito. 2011. Determination of Subcellular Localization of Flavonol in Cultured Cells by Laser Scanning. In Laser Scanning, Theory and Applications. C. Wang (Ed.), ISBN: 978-953-307-205-0.
Pauken, C.M., and M.R. Caplan. 2011. Temporal differences in Erk1/2 activity distinguish among combinations of extracellular matrix components. Acta Biomaterialia. 7:3973-3980.
Rivera, V.M., R.M. Squillace, D. Miller, L. Berk, S.D. Wardwell, Y. Ning, R. Pollock, N.I. Narasimhan, J.D. Iuliucci, and F. Wang. 2011. Ridaforolimus (AP23573; MK-8669), a potent mTOR inhibitor, has broad antitumor activity and can be optimally administered using intermittent dosing regimens. Molecular cancer therapeutics. 10:1059-1071.
Rössler, J., Y. Monnet, F. Farace, P. Opolon, E. Daudigeos-Dubus, A. Bourredjem, G. Vassal, and B. Geoerger. 2011. The selective VEGFR1-3 inhibitor axitinib (AG-013736) shows antitumor activity in human neuroblastoma xenografts. International Journal of Cancer. 128:2748-2758.
Sanna, V., G. Pintus, A.M. Roggio, S. Punzoni, A.M. Posadino, A. Arca, S. Marceddu, P. Bandiera, S. Uzzau, and M. Sechi. 2011. Targeted biocompatible nanoparticles for the delivery of (−)-epigallocatechin 3-gallate to prostate cancer cells. Journal of medicinal chemistry. 54:1321-1332.
Sharma, V., and H.H. Freeze. 2011a. Mannose Efflux from the Cells: A POTENTIAL SOURCE OF MANNOSE IN BLOOD. Journal of Biological Chemistry. 286:10193-10200.
Sharma, V., M. Ichikawa, P. He, Y. Bravo, R. Dahl, B. Ng, N. Cosford, and H. Freeze. 2011. Phosphomannose Isomerase Inhibitors Improve N-Glycosylation in Selected Phosphomannomutase-deficient Fibroblasts. JCB, 286:39431-39438.
Xu, H., M. Zaidi, J. Struve, D.W. Jones, J.G. Krolikowski, S. Nandedkar, N.L. Lohr, A. Gadicherla, P.S. Pagel, M.E. Csuka, K.A. Pritchard, and D. Weihrauch. 2011. Abnormal fibrillin-1 expression and chronic oxidative stress mediate endothelial mesenchymal transition in a murine model of systemic sclerosis. American Journal of Physiology - Cell Physiology. 300:C550-C556.
Yoshikawa, A., Y. Aizaki, K.-i. Kusano, F. Kishi, T. Susumu, S. Iida, S. Ishiura, S. Nishimura, M. Shichiri, and T. Senbonmatsu. 2011. The (pro)renin receptor is cleaved by ADAM19 in the Golgi leading to its secretion into extracellular space. Hypertension research. 34:599-605.
2010
Edwards, D., M. Berens, and C. Beaudry. 2010. Cell migration inhibiting compositions and methods and compositions for treating cancer. Patent US 7700615 B2.
Flores, L. 2010. Mechanisms of the anti-inflammation action of pulsatile laminar flow : role of AMPK in epigenetic modifications. PhD Dissertation, UCSD.
Heberlein, K., A. Straubb, A. Best, M. Greyson, R. Looft-Wilson, P. Sharma, A. Meher, N. Leitinger, and B. Isakson. 2010. Plasminogen Activator Inhibitor-1 Regulates Myoendothelial Junction Formation. Circulation Research, 106:1092-1102.
Inoshima, Y and N. Ishguro. 2010. Molecular and biological characterization of vascular endothelial growth factor of parapoxviruses isolated from wild Japanese serows (Capricornis crispus). Veterinary Microbiology, 140:63-71. HUVEC
Jacky, B., P. Garay, Y. Molina, D. Stathakis, J. Francis, K. Aoki, and E. Fernandez-Salas. 2010. Methods of Treating Cancer Using Opioid Retargeted Endopepidases. Patent Application US 20110064713 A1.
Jacky, B. P. Garay, Y. Molina, D. Stathakis, J. Francis, K. Aoki, and E. Fernandez-Salas. 2010. Methods of Treating Cancer Using Glucagon-Like Hormone Retargeted Endopeptidases. Patent Application US 20110070212 A1.
Koai, E., T. Rios, and J. Edwards. 2010. Vascular Endothelial Growth Factor Increases Endothelial Nitric Oxide Synthase Transcription In Huvec Cells. WebmedCentral PHYSIOLOGY 2010;1(11):WMC001111, doi: 10.9754/journal.wmc.2010.001111.
Lionetti, V., S. Cantoni, C. Cavallini, F. Bianchi, S. Valente, I. Frascari, E. Olivi, G. Aquaro, F. Bonavita, I. Scarlata, M. Maioli, V. Vaccari, R. Tassinari, A. Bartoli, F. Recchia, G. Pasquinelli, and C. Ventura. 2010. Hyaluronan Mixed Esters of Butyric and Retinoic Acid Affording Myocardial Survival and Repair without Stem Cell Transplantation. JBC, 285:9949-9961.
Miyake, Y., M. Mochizuki, C. Ito, M. Itoigawa, and T. Osawa. 2010. Peroxynitrite Scavengers Produced by Filamentous Fungus Used in the Katsuobushi Manufacturing Process. Food science and technology research. 16:493-498.
Mochizuki, M., Y. Tsuchie, N. Yamada, Y. Miyake, and T. Osawa. 2010. Effect of sesame lignans on TNF-α-induced expression of adhesion molecules in endothelial cells. Bioscience, biotechnology, and biochemistry. 74:1539-1544.
Nivison-Smith, L., J. Rnjak, and A.S. Weiss. 2010. Synthetic human elastin microfibers: Stable cross-linked tropoelastin and cell interactive constructs for tissue engineering applications. Acta Biomaterialia. 6:354-359.
Pasciu, V., A.M. Posadino, A. Cossu, B. Sanna, B. Tadolini, L. Gaspa, A. Marchisio, S. Dessole, G. Capobianco, and G. Pintus. 2010. Akt Downregulation by Flavin Oxidase–Induced ROS Generation Mediates Dose-Dependent Endothelial Cell Damage Elicited by Natural Antioxidants. Toxicological Sciences. 114:101-112.
Patel, N.S., V.S. Mathura, C. Bachmeier, D. Beaulieu-Abdelahad, V. Laporte, O. Weeks, M. Mullan, and D. Paris. 2010. Alzheimer’s β-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2. Journal of Neurochemistry. 112:66-76.
Sheikh-Ali, M., S. Sultan, A.-R. Alamir, M.J. Haas, and A.D. Mooradian. 2010a. Effects of antioxidants on glucose-induced oxidative stress and endoplasmic reticulum stress in endothelial cells. Diabetes research and clinical practice. 87:161-166.
Sheikh-Ali, M., S. Sultan, A.-R. Alamir, M.J. Haas, and A.D. Mooradian. 2010b. Hyperglycemia-induced endoplasmic reticulum stress in endothelial cells. Nutrition. 26:1146-1150.
Thebaud, N. 2010. Cellules endothéliales issues de progéniteurs humains : des acteurs pertinents en ingénierie vasculaire? PhD Dissertation, L’UNIVERSITÉ BORDEAUX 2.
Zhang, Y., W. Schulte, D. Pink, K. Phipps, A. Zijlstra, J.D. Lewis, and D.M. Waisman. 2010. Sensitivity of Cancer Cells to Truncated Diphtheria Toxin. PloS one. 5:e10498.
2009
Himmelhaus, M., and A. Francois. 2009. In-vitro sensing of biomechanical forces in live cells by a whispering gallery mode biosensor. Biosensors and Bioelectronics. 25:418-427.
Himmelhaus, M., and A. Francois. 2009. Method for sensing a biochemical and/or biomechanical process of a biological material and method for analyzing biological materials. Patent Application US 20110256577 A1.
Islam, M.K., N. Tsuji, T. Miyoshi, M.A. Alim, X. Huang, T. Hatta, and K. Fujisaki. 2009. The Kunitz-Like Modulatory Protein Haemangin Is Vital for Hard Tick Blood-Feeding Success. PLoS Pathog. 5:e1000497.
Kawashiro, Y., H. Fukata, K. Sato, H. Aburatani, H. Takigami, and C. Mori. 2009. Polybrominated diphenyl ethers cause oxidative stress in human umbilical vein endothelial cells. Human & Experimental Toxicology. 28:703-713.
Kimura, M., Y. Kato, D. Sano, K. Fujita, A. Sakakibara, N. Kondo, Y. Mikami, and M. Tsukuda. 2009. Soluble form of ephrinB2 inhibits xenograft growth of squamous cell carcinoma of the head and neck. International journal of oncology. 34:321-327.
Tang, S.Y., I.K. Cheah, H. Wang, and B. Halliwell. 2009. Notopterygium forbesii Boiss extract and its active constituent phenethyl ferulate attenuate pro-inflammatory responses to lipopolysaccharide in RAW 264.7 macrophages. A “protective” role for oxidative stress? Chemical research in toxicology. 22:1473-1482.
Wu, J.C., A. Chruscinski, V.A. De Jesus Perez, H. Singh, M. Pitsiouni, M. Rabinovitch, P.J. Utz, and J.P. Cooke. 2009. Cholinergic modulation of angiogenesis: role of the 7 nicotinic acetylcholine receptor. Journal of cellular biochemistry. 108:433-446.
Yang, P., T. Hong, Y. Chen, A. Yuan, and Y. Wu. 2009. COMPOSITION FOR TREATING CANCER AND USE THEREOF. Patent Application 20090197798 A1.
Yang, P., T. Hong, Y. Chen, A, Yuan, and Y. We. 2009. Synthetic anti-neuropilin 1 (NRP1) cyclic peptide containing RRXR motif. Patent US 7601693 B2.
Yanagida, K., K. Masago, H. Nakanishi, Y. Kihara, F. Hamano, Y. Tajima, R. Taguchi, T. Shimizu, and S. Ishii. 2009. Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6. Journal of Biological Chemistry. 284:17731-17741.
Yoshie, M., E. Miyajima, S. Kyo, and K. Tamura. 2009. Stathmin, a Microtubule Regulatory Protein, Is Associated with Hypoxia-Inducible Factor-1α Levels in Human Endometrial and Endothelial Cells. Endocrinology. 150:2413-2418.
2008
Kim, C.-S., S.-B. Jung, A. Naqvi, T.A. Hoffman, J. DeRicco, T. Yamamori, M.P. Cole, B.-H. Jeon, and K. Irani. 2008. P53 Impairs Endothelium-Dependent Vasomotor Function Through Transcriptional Upregulation of P66shc. Circulation research. 103:1441-1450.
Madasamy, S. 2008. Multi-subunit biological complexes for treatment of plaque-associated diseases. Patent Application US 20090104121 A1.
Rocha, F.G., C.A. Sundback, N.J. Krebs, J.K. Leach, D.J. Mooney, S.W. Ashley, J.P. Vacanti, and E.E. Whang. 2008. The effect of sustained delivery of vascular endothelial growth factor on angiogenesis in tissue-engineered intestine. Biomaterials. 29:2884-2890.
Syeda, F., E. Tullis, A.S. Slutsky, and H. Zhang. 2008. Human neutrophil peptides upregulate expression of COX-2 and endothelin-1 by inducing oxidative stress. Am J Physiol 294:H2769-H2774.
Yamanaka, M., Y. Anada, Y. Igarashi, and A. Kihara. 2008. A splicing isoform of LPP1, LPP1a, exhibits high phosphatase activity toward FTY720 phosphate. Biochemical and biophysical research communications. 375:675-679.
2007
Ali, M.A., H. Choy, A.A. Habib, and D. Saha. 2007. SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor. Neoplasia (New York, NY). 9:370.
Carratelli, C.R., R. Paolillo, and A. Rizzo. 2007. Chlamydia pneumoniae stimulates the proliferation of HUVEC through the induction of VEGF by THP-1. International Immunopharmacology. 7:287-294.
Hollingsworth, J.W., Z. Li, D.M. Brass, S. Garantziotis, S.H. Timberlake, A. Kim, I. Hossain, R.C. Savani, and D.A. Schwartz. 2007. CD44 regulates macrophage recruitment to the lung in lipopolysaccharide-induced airway disease. American journal of respiratory cell and molecular biology. 37:248.
Hong, T.-M., Y.-L. Chen, Y.-Y. Wu, A. Yuan, Y.-C. Chao, Y.-C. Chung, M.-H. Wu, S.-C. Yang, S.-H. Pan, J.-Y. Shih, W.-K. Chan, and P.-C. Yang. 2007. Targeting Neuropilin 1 as an Antitumor Strategy in Lung Cancer. Clinical Cancer Research. 13:4759-4768.
Mattagajasingh, I., C.-S. Kim, A. Naqvi, T. Yamamori, T.A. Hoffman, S.-B. Jung, J. DeRicco, K. Kasuno, and K. Irani. 2007. SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences. 104:14855-14860.
Omori, N., H. Fukata, K. Sato, K. Yamazaki, K. Aida-Yasuoka, H. Takigami, M. Kuriyama, M. Ichinose, and C. Mori. 2007. Polychlorinated biphenyls alter the expression of endothelial nitric oxide synthase mRNA in human umbilical vein endothelial cells. Human & Experimental Toxicology. 26:811-816.
Shibata, M., J. Morimoto, H. Doi, S. Morishima, M. Naka, and Y. Otsuki. 2007. Electrogene therapy using endostatin, with or without suicide gene therapy, suppresses murine mammary tumor growth and metastasis. Cancer Gene Therapy, 14:268-278.
Wu, X., K. Mahadev, L. Fuchsel, R. Ouedraogo, S.-q. Xu, and B.J. Goldstein. 2007. Adiponectin suppresses IκB kinase activation induced by tumor necrosis factor-α or high glucose in endothelial cells: role of cAMP and AMP kinase signaling. American Journal of Physiology - Endocrinology and Metabolism. 293:E1836-E1844.
Zhao, X., J. Hu, and L. Yang. Identification of One Vasculature Specific Phage-displayed Peptide in Human Colon Cancer. J. Exp. Clin. Cancer Res., 26:509-514.
2006
Kamiyoshi, A., T. Sakurai, Y. Ichikawa-Shindo, J. Fukuchi, H. Kawate, S.-i. Muto, Y.-i. Tagawa, and T. Shindo. 2006. Endogenous αCGRP protects against concanavalin A-induced hepatitis in mice. Biochemical and biophysical research communications. 343:152-158.
Edwards, D., M. Berens, and C. Beaudry. 2006. Cell migration inhibiting compositions and methods and compositions for treating cancer. Patent US 7012100 B1.
Haas, M.J., M.H. Horani, S.A. Parseghian, and A.D. Mooradian. 2006. Statins Prevent Dextrose-Induced Endothelial Barrier Dysfunction, Possibly Through Inhibition of Superoxide Formation. Diabetes. 55:474-479.
Horani, M.H., M.J. Haas, and A.D. Mooradian. 2006a. Saturated, unsaturated, and trans-fatty acids modulate oxidative burst induced by high dextrose in human umbilical vein endothelial cells. Nutrition. 22:123-127.
Horani, M.H., M.J. Haas, and A.D. Mooradian. 2006b. Suppression of Hyperglycemia-Induced Superoxide Formation and Endothelin-1 Gene Expression by Carvedilol. American Journal of Therapeutics. 13:2-7.
Shibata, M.-A., Y. Ito, J. Morimoto, K. Kusakabe, R. Yoshinaka, and Y. Otsuki. 2006b. In vivo electrogene transfer of interleukin-12 inhibits tumor growth and lymph node and lung metastases in mouse mammary carcinomas. The journal of gene medicine. 8:335-352.
2005
Bernier, S.G., N. Taghizadeh, C.D. Thompson, W.F. Westlin, and G. Hannig. 2005. Methionine aminopeptidases type I and type II are essential to control cell proliferation. Journal of cellular biochemistry. 95:1191-1203.
Csiszar, A., K.E. Smith, A. Koller, G. Kaley, J.G. Edwards, and Z. Ungvari. 2005. Regulation of Bone Morphogenetic Protein-2 Expression in Endothelial Cells: Role of Nuclear Factor-κΒ Activation by Tumor Necrosis Factor-α, H2O2, and High Intravascular Pressure. Circulation. 111:2364-2372.
Kawamura, Y.I., R. Kawashima, R. Fukunaga, K. Hirai, N. Toyama-Sorimachi, M. Tokuhara, T. Shimizu, and T. Dohi. 2005. Introduction of Sda Carbohydrate Antigen in Gastrointestinal Cancer Cells Eliminates Selectin Ligands and Inhibits Metastasis. Cancer research. 65:6220-6227.
Miho, N., T. Ishida, N. Kuwaba, M. Ishida, K. Shimote-Abe, K. Tabuchi, T. Oshima, M. Yoshizumi, and K. Chayama. 2005. Role of the JNK pathway in thrombin-induced ICAM-1 expression in endothelial cells. Cardiovascular Research. 68:289-298.
Papaconstantinou, M.E., C.J. Carrell, A.O. Pineda, K.M. Bobofchak, F.S. Mathews, C.S. Flordellis, M.E. Maragoudakis, N.E. Tsopanoglou, and E. Di Cera. 2005. Thrombin Functions through Its RGD Sequence in a Non-canonical Conformation. Journal of Biological Chemistry. 280:29393-29396.
Takii, R., T. Kadowaki, A. Baba, T. Tsukuba, and K. Yamamoto. 2005. A Functional Virulence Complex Composed of Gingipains, Adhesins, and Lipopolysaccharide Shows High Affinity to Host Cells and Matrix Proteins and Escapes Recognition by Host Immune Systems. Infection and Immunity. 73:883-893.
2004
Han, K.H., K.-H. Hong, J.-H. Park, J. Ko, D.-H. Kang, K.-J. Choi, M.-K. Hong, S.-W. Park, and S.-J. Park. 2004. C-Reactive Protein Promotes Monocyte Chemoattractant Protein-1—Mediated Chemotaxis Through Upregulating CC Chemokine Receptor 2 Expression in Human Monocytes. Circulation. 109:2566-2571.
Horani, M.H., M.J. Haas, and A.D. Mooradian. 2004. Rapid adaptive down regulation of oxidative burst induced by high dextrose in human umbilical vein endothelial cells. Diabetes Research and Clinical Practice. 66:7-12.
Kasuya, H., T.M. Pawlik, J.T. Mullen, J.M. Donahue, H. Nakamura, S. Chandrasekhar, H. Kawasaki, E. Choi, and K.K. Tanabe. 2004. Selectivity of an Oncolytic Herpes Simplex Virus for Cells Expressing the DF3/MUC1 Antigen. Cancer research. 64:2561-2567.
2003
Gustafson, D.L., D. Siegel, J.C. Rastatter, A.L. Merz, J.C. Parpal, J.K. Kepa, D. Ross, and M.E. Long. 2003. Kinetics of NAD(P)H:Quinone Oxidoreductase I (NQO1) Inhibition by Mitomycin C in Vitro and in Vivo. J. Pharmacol. & Exp. Therapeutics. 305:1079-1086.
Han, K.H., Y. Chen, M.K. Chang, Y.C. Han, J.-H. Park, S.R. Green, A. Boullier, and O. Quehenberger. 2003. LDL activates signaling pathways leading to an increase in cytosolic free calcium and stimulation of CD11b expression in monocytes. Journal of lipid research. 44:1332-1340.
Hirono, S., E. Dibrov, C. Hurtado, A. Kostenuk, R. Ducas, and G.N. Pierce. 2003. Chlamydia pneumoniae Stimulates Proliferation of Vascular Smooth Muscle Cells Through Induction of Endogenous Heat Shock Protein 60. Circulation research. 93:710-716.
Li, Y., F. Spencer, and R. Becker. 2003. Plasmin-Mediated Proteolysis of Vascular Endothelial Cell Heparin Releasable Tissue Factor Pathway Inhibitor. Journal of Thrombosis and Thrombolysis, 15:19-23.
Lu, T.-S., H.-W. Chen, S.-I. Lue, S.-J. Wang, M.-F. Kuo, and R.-C. Yang. 2003. The protective mechanism of heat shock treatment on the disruption of tight junction of endothelial cells. In FASEB JOURNAL. Vol. 17. FEDERATION AMER SOC EXP BIOL 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA. A64-A64.
Mori, C. 2003. Application of Toxicogenomic Analysis to Risk Assessment of Delayed Long-Term Effects of Multiple Chemicals Including Endocrine Disruptors in Human Fetuses. Environ Health Perspect, 111:803-804.
Ueshima, J., M. Shoji, D.B. Ratnayake, K. Abe, S. Yoshida, K. Yamamoto, and K. Nakayama. 2003. Purification, Gene Cloning, Gene Expression, and Mutants of Dps from the Obligate Anaerobe Porphyromonas gingivalis. Infection and Immunity. 71:1170-1178.
2002
Montes, R.A.O., J.R. Eckman, L.L. Hsu, and T.M. Wick. 2002. Sickle erythrocyte adherence to endothelium at low shear: Role of shear stress in propagation of vaso-occlusion. American Journal of Hematology. 70:216-227.
Mullen, J.T., H. Kasuya, S.S. Yoon, N.M. Carroll, T.M. Pawlik, S. Chandrasekhar, H. Nakamura, J.M. Donahue, and K.K. Tanabe. 2002. Regulation of herpes simplex virus 1 replication using tumor-associated promoters. Annals of surgery. 236:502.
Sato, S., N. Ouellet, I. Pelletier, M. Simard, A. Rancourt, and M.G. Bergeron. 2002. Role of Galectin-3 as an Adhesion Molecule for Neutrophil Extravasation During Streptococcal Pneumonia. The Journal of Immunology. 168:1813-1822.
2000
Wittmann, V., A.K. Datta, K.M. Koeller, and C.-H. Wong. 2000. Chemoenzymatic synthesis and fluorescent visualization of cell-surface selectin-bound sialyl Lewis x derivatives. CHEMISTRY-WEINHEIM-EUROPEAN JOURNAL-. 6:162-171.
1998
Starnes, J. 1998. Alteration of Immune Responses by Cocaine: Cytokines and Reactive Nitrogen Intermediates. Masters Thesis, Texas Tech University, http://hdl.handle.net/2346/16554.