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Description
Human Dermal Microvascular Endothelial Cells (CADMEC / HMVEC) from Cell Applications, Inc. provide an excellent model system to study many aspects of endothelial function and disease, especially those related to the microvasculature and capillary systems. These cells were trademarked by Cell Applications, Inc. over 20 years ago, when they were first offered, and CADMEC™ stands for “Cell Applications’ Dermal Microvascular Endothelial Cells”. HMVEC/CADMEC have been shown to express vWF, CD36 and CD31, are able to uptake DiI-Ac-LDL and are positive for functional activity by cytokine-stimulated leukocyte adherence.
Select HMVEC lots have been additionally tested to demonstrate stimulation-dependent angiogenesis and key endothelial cell signaling pathways (phosphorylation of VEGFR2). See the Pre-Screened Endothelial Cell Product Page for more information.
CADMEC/HMVEC from Cell Applications, Inc. have been used in numerous research publications, for example to:
- Show that cytokine-activated microvascular endothelial cells upregulate expression of α2-6-linked sialic acids which are the ligands for CD22 on the surface of the B cells, increasing the adhesion between the two cell types
- Show that IL-1, TNF and IFN stimulated ICAM-1 and E-selectin production by microvascular endothelial cells and resulted in a higher leukocyte adhesion that could be prevented by dexamethasone
- Demonstrate that FGF-2, but not FGF-13, induces proliferation of microvascular endothelial cells, and that neither growth factor affected IL-6 production
- Map VEGF signaling pathway by demonstrating that c-Src phosphorylates VEGFR-2 and IQGAP1, leading to activation of b-Raf, causing endotheial cell proliferation and angiogenesis
- Demonstrate that mechanical signals promote endothelial cell proliferation via VEGFR2/Akt signaling cascade leading to inactivation of GSK3β and preventing cyclin D1 degradation
- Show that endothelial permeability caused by advanced glycation end products results from RhoA/ROCK and p38 dependent moesin phosphorylation leading to actin reorganization
- Demonstrate, along with Human Coronary Artery Endothelial Cells, also from Cell Applications, Inc., the role of AMP-activated protein kinase (AMPK) in preservation of the tight junctions, explaining the heightened vascular permeability when AMPK is inhibited due to exposure to lipopolysaccharides during sepsis
- Demonstrate that the endothelial to mesenchymal transition associated with portal venous stenosis is mediated by increased serum levels of TGF-b1 in idiopathic portal hypertension patients, which induced fibroblast-like morphology, reduction of CD34 expression, and induction of α-smooth muscle actin, COL1A1 and phospho-Smad2, and that BMP-7 was able to prevent these changes (Kitao, 2009);
- Reveal a critical role for the α7 nAChR in mediating the effects of nicotine on the endothelium
- Show that abnormal matrix composition characteristic for systemic sclerosis, leads to reduced proliferation, reduced NO-to-O2- ratio, increased apoptosis, and altered protein expression associated with endothelial to mesenchymal transition, all leading to impaired vascular function and angiogenesis
- Develop anti-tumor apoptosis-inducing peptides that selectively target angiogenic cells and a targeted gene delivery system, PEI-g-PEG-RGD, for efficient expression of soluble fragment of VEGF receptor Flt-1 (sFlt-1) gene in order to inhibit tumor-related angiogenesis
- Identify a novel tumor-derived angiogenic factor, gastrin-releasing peptide, and its small molecule inhibitor, 77427
- Evaluate, along with Human Pulmonary Artery Endothelial Cells (HPAEC) and Human Umbilical Cord Vascular Endothelial Cells (HUVEC), all obtained from Cell Applications, Inc., the cytotoxic effects of a novel pore-forming protein, proposed as an anti-tumor agent
- To confirm the antioxidant and anti-inflammatory effects of blueberry and cranberry anthocyanins and hydroxycinnamic acids against H2O2 and TNFα induced damage to microvascular endothelial cells, by demonstrating reduction in oxidative stress and lowered production of IL-8, MCP-1 and ICAM-1 and show that procyanidins isolated from cocoa inhibit the expression of ErbB2 gene, decreasing cell proliferation and angiogenesis (Kenny, 2004);
- Demonstrate secretion of adipogenic factor(s) by microvascular endothelial cells
(Cllick to Enlarge) Cell Applications Dermal Microvascular Endothelial Cells / Human Microvascular Endothelial Cells (CADMEC / HMVEC) Mono-layer (L), vessel-like structures formed in an angiogenesis assay (M), and immunolabeled for CD31/PECAM (green). Nuclei are visualized with PI (red) (R).
Details
Tissue | Normal healthy human neonatal foreskin or adult skin capillaries |
QC | No bacteria, yeast, fungi, mycoplasma |
Character | Factor VIII-related Ag, DiI-Ac-LDL uptake |
| Bioassay | Attach, spread, proliferate in Growth Med |
Cryovial | 500,000 CADMEC frozen in Basal Med w/ 10% FBS, 10% DMSO |
Kit | Cryovial frozen CADMEC (100-05), Gr Med (112-500), Subcltr Rgnt Kit, 2 Attchmnt Factor-Coated T-25 Flasks (121-25-02), Attchmnt Fctr Soln (123-100) |
Proliferating | Shipped in Tsfr Med, 3rd psg (flasks or plates) |
Doublings | At least 16 |
Applications | Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use. |
Products
| Product | Size | CAT.# | Price | Quantity |
|---|---|---|---|---|
| Cryopreserved Dermal Microvascular Endothelial Cells (CADMEC/HMVEC) Total Kit, adult: 5x10^5 Cells (Adult), Medium & Subculture Reagents (See Details tab for specifics) | Size: 1 Kit | CAT.#: 100K-05a | Price: $972.00 | |
| Cryopreserved Dermal Microvascular Endothelial Cells (CADMEC), adult: Frozen CADMEC (5x10^5) | Size: 1 Cryovial | CAT.#: 100-05a | Price: $675.00 | |
| Proliferating Dermal Microvascular Endothelial Cells (CADMEC), adult: Actively growing, dividing cells in medium | Size: T-25 Flask | CAT.#: 101-25a | Price: $675.00 | |
| Proliferating Dermal Microvascular Endothelial Cells (CADMEC), adult: Actively growing, dividing cells in medium | Size: T-75 Flask | CAT.#: 101-75a | Price: $865.00 | |
| Proliferating Dermal Microvascular Endothelial Cells (CADMEC), adult: Actively growing, dividing cells in medium | Size: 24 Well | CAT.#: 101-24Wa | Price: $865.00 | |
| Proliferating Dermal Microvascular Endothelial Cells (CADMEC), adult: Actively growing, dividing cells in medium | Size: 96 Well | CAT.#: 101-96Wa | Price: $985.00 | |
| Cryopreserved Dermal Microvascular Endothelial Cells (CADMEC/HMVEC) Total Kit, neonatal: 5x10^5 Cells (Neonatal), Medium & Subculture Reagents (See Details tab for specifics) | Size: 1 Kit | CAT.#: 100K-05n | Price: $922.00 | |
| Cryopreserved Dermal Microvascular Endothelial Cells (CADMEC), neonatal: Frozen CADMEC (5x10^5) | Size: 1 Cryovial | CAT.#: 100-05n | Price: $625.00 | |
| Proliferating Dermal Microvascular Endothelial Cells (CADMEC), neonatal: Proliferating CADMEC | Size: T-25 Flask | CAT.#: 101-25n | Price: $625.00 | |
| Proliferating Dermal Microvascular Endothelial Cells (CADMEC), neonatal: Proliferating CADMEC | Size: T-75 Flask | CAT.#: 101-75n | Price: $815.00 | |
| Proliferating Dermal Microvascular Endothelial Cells (CADMEC), neonatal: Proliferating CADMEC | Size: 24 well | CAT.#: 101-24Wn | Price: $815.00 | |
| Proliferating Dermal Microvascular Endothelial Cells (CADMEC), neonatal: Actively growing, dividing cells, in medium | Size: 96 Well | CAT.#: 101-96Wn | Price: $935.00 | |
| Cryopreserved Pre-Screened Cryopreserved Dermal Microvascular Endothelial Cell Total Kit: 5x10^5 Cells (Pre-Screened, Adult), Medium & Subculture Reagents (See Details tab for specifics) | Size: 1 Kit | CAT.#: S100K-05a | Price: $1,122.00 | |
| Cryopreserved Dermal Microvascular Endothelial Cells (CADMEC), Pre-Screened, adult: Frozen CADMEC/HMVEC (5x10^5) | Size: 1 Cryovial | CAT.#: S100-05a | Price: $825.00 | |
| Cryopreserved Pre-Screened Cryopreserved Dermal Microvascular Endothelial Cell Total Kit: 5x10^5 Cells (Pre-Screened, Neonatal), Medium & Subculture Reagents (See Details tab for specifics) | Size: 1 Kit | CAT.#: S100K-05n | Price: $1,122.00 | |
| Cryopreserved Dermal Microvascular Endothelial Cells (CADMEC), Pre-Screened, neonatal: Frozen CADMEC (5x10^5) | Size: 1 Cryovial | CAT.#: S100-05n | Price: $825.00 | |
| Proliferating Dermal Microvascular Endothelial Cells (S-CADMEC), Pre-Screened, adult: Actively growing, dividing cells in medium | Size: T-25 Flask | CAT.#: S101-25a | Price: $825.00 | |
| Proliferating Dermal Microvascular Endothelial Cells (S-CADMEC), Pre-Screened, adult: Actively growing, dividing cells in medium | Size: T-75 Flask | CAT.#: S101-75a | Price: $1,015.00 | |
| Proliferating Dermal Microvascular Endothelial Cells (S-CADMEC), Pre-Screened, adult: Actively growing, dividing cells in medium | Size: 24 Well | CAT.#: S101-24Wa | Price: $1,015.00 | |
| Proliferating Dermal Microvascular Endothelial Cells (S-CADMEC), Pre-Screened, adult: Actively growing, dividing cells in medium | Size: 96 Well | CAT.#: S101-96Wa | Price: $1,135.00 |
Related Products
| Product | Size | CAT.# | Price | Quantity |
|---|---|---|---|---|
| CADMEC Growth Medium: All-in-one ready-to-use | Size: 500 ml | CAT.#: 112-500 | Price: $187.00 | |
| CADMEC Growth Medium Kit: Basal medium & growth supplement sold together packaged separately | Size: Yields 500 ml | CAT.#: 112K-500 | Price: $201.00 | |
| CADMEC Basal Medium: Basal medium (contains no growth supplement). Add GS before use. | Size: 500 ml | CAT.#: 110-500 | Price: $74.00 | |
| CADMEC Growth Supplement: Added to Basal Medium to create Growth Medium | Size: 30 ml | CAT.#: 112-GS | Price: $153.00 | |
| CADMEC Growth Medium wo Phenol Red: Growth Medium without phenol red | Size: 500 ml | CAT.#: 112PR-500 | Price: $233.00 | |
| CADMEC Growth Medium Kit wo Phenol Red: Growth Medium Kit without phenol red | Size: yields 500 ml | CAT.#: 112KPR-500 | Price: $246.00 | |
| CADMEC Growth Medium wo FBS: Growth medium without FBS | Size: 500 ml | CAT.#: 112F-500 | Price: $201.00 | |
| CADMEC Growth Medium wo Phosphate: Growth medium without phospate | Size: 500 ml | CAT.#: 112P-500 | Price: $233.00 | |
| CADMEC Basal Medium wo Phenol Red: Basal medium without phenol red | Size: 500 ml | CAT.#: 110PR-500 | Price: $95.00 | |
| CADMEC Cord Formation Med wo Serum, Growth Factors: Designed to induce tubule formation of CADMEC on Attachment Factor coated tissue culture ware in 50%-60% confluent culture. Does not contain serum and does not support EC growth. | Size: 500 ml | CAT.#: 114-500 | Price: $130.00 | |
| CADMEC Cord Formation Med wo Serum, Growth Factors, Phenol Red: Designed to induce tubule formation of CADMEC on Attachment Factor coated tissue culture ware in 50%-60% confluent culture. Does not contain serum or phenol red, and does not support EC growth. | Size: 500 ml | CAT.#: 114PR-500 | Price: $136.00 |
Extended Family Products
| Product | Size | CAT.# | Price | Quantity |
|---|---|---|---|---|
| Anti-ICAM-1: Rabbit Intercellular Adhesion Molecule-1 Antibody | Size: 100 ul | CAT.#: CG1238 | Price: $275.00 | |
| Polyclonal Vascular Endothelial Growth Factor Antibody: Polyclonal Vascular Endothelial Growth Factor Antibody | Size: 100 ul | CAT.#: CA1080 | Price: $302.00 | |
| Polyclonal Vascular Endothelial Growth Factor-C Antibody: Polyclonal Vascular Endothelial Growth Factor-C Antibody | Size: 100 ul | CAT.#: CB3778 | Price: $302.00 | |
| Polyclonal VEGF Receptor 1 Antibody: Polyclonal VEGF Receptor 1 Antibody | Size: 100 ul | CAT.#: CB3839 | Price: $333.00 | |
| Attachment Factor Solution (AFS): AFS, contains Bovine Gelatin | Size: 100 ml | CAT.#: 123-100 | Price: $22.00 | |
| Dermal Microvascular Endothelial Cell RNA (CADMEC RNA), Stimulated, Adult: Total RNA prepared from Human Dermal Microvascular Endothelial Cells, Stimulated, adult | Size: 10 ug | CAT.#: 100S-R10a | Price: $465.00 | |
| Dermal Microvascular Endothelial Cell RNA (CADMEC RNA), Stimulated, Adult: Total RNA prepared from Human Dermal Microvascular Endothelial Cells, Stimulated, adult | Size: 25 ug | CAT.#: 100S-R25a | Price: $930.00 | |
| Dermal Microvascular Endothelial Cell RNA (CADMEC RNA), Stimulated, Fetal: Total RNA prepared from Human Dermal Microvascular Endothelial Cells, Stimulated, neonatal | Size: 10 ug | CAT.#: 100S-R10n | Price: $465.00 | |
| Dermal Microvascular Endothelial Cell RNA (CADMEC RNA), Adult: Total RNA prepared from Human Dermal Microvascular Endothelial Cells, adult | Size: 10 ug | CAT.#: 100-R10a | Price: $398.00 | |
| Dermal Microvascular Endothelial Cell RNA (CADMEC RNA), Adult: Total RNA prepared from Human Dermal Microvascular Endothelial Cells, adult | Size: 25 ug | CAT.#: 100-R25a | Price: $796.00 | |
| Dermal Microvascular Endothelial Cell RNA (CADMEC RNA), Neonatal: Total RNA prepared from Human Dermal Microvscular Endothelial Cells, neonatal | Size: 10 ug | CAT.#: 100-R10n | Price: $398.00 | |
| Dermal Microvascular Endothelial Cell RNA (CADMEC RNA), Neonatal: Total RNA prepared from Human Dermal Microvscular Endothelial Cells, neonatal | Size: 25 ug | CAT.#: 100-R25n | Price: $796.00 | |
| Freezing Medium: For general cryopreservation of most primary cells. Contains FBS & DMSO. | Size: 50 ml | CAT.#: 040-50 | Price: $54.00 | |
| Cyto-X Cell Counting Reagent: 500 tests | Size: 1 Bottle | CAT.#: 028-01 | Price: $160.00 | |
| Cyto-X Cell Counting Reagent Sample: 100 tests | Size: Sample | CAT.#: 028-S | Price: $41.00 | |
| Cytofect Endothelial Cell Transfection Kit (250 x 24-Wells): 250 x 24-Well Rxns | Size: 1 Kit | CAT.#: TF101K | Price: $496.00 | |
| Cytofect Endothelial Cell Transfection Sample Kit (25 x 24-Wells): 25 x 24-Well Rxns | Size: 1 Sample Kit | CAT.#: TF101KS | Price: $62.00 | |
| Human E-Selectin ELISA Kit: Human E-Selectin ELISA Kit | Size: 96 Wells | CAT.#: CL0501 | Price: $587.00 | |
| Human ICAM-1 ELISA Kit: Human Intercellular Adhesion Molecule-1 ELISA Kit | Size: 96 Wells | CAT.#: CL0370 | Price: $484.00 | |
| Human Gamma-Interferon Inducible Protein 10 (IP-10 / CXCL10): Human gamma-Interferon Inducible Protein 10 | Size: 25 ug | CAT.#: RP1127-25 | Price: $194.00 | |
| Human Gamma-Interferon Inducible Protein 10 (IP-10 / CXCL10): Human gamma-Interferon Inducible Protein 10 | Size: 100 ug | CAT.#: RP1127-100 | Price: $484.00 | |
| Human Gamma-Interferon Inducible Protein 10 (IP-10 / CXCL10): Human gamma-Interferon Inducible Protein 10 | Size: 1000 ug | CAT.#: RP1127-1000 | Price: $3,175.00 | |
| Human P-Selectin ELISA Kit: Human P-Selectin ELISA Kit | Size: 96 wells | CAT.#: CL0505 | Price: $517.00 | |
| Subculture Reagent Kit: 100 ml each of HBSS, Trypsin/EDTA & Trypsin Neutralizing Solution | Size: 1 Kit | CAT.#: 090K | Price: $63.00 | |
| Human Vascular Endothelial Growth Factor-121 (VEGF-121): Human Vascular Endothelial Growth Factor-121 | Size: 10 ug | CAT.#: RP1116-10 | Price: $194.00 | |
| Human Vascular Endothelial Growth Factor-121 (VEGF-121): Human Vascular Endothelial Growth Factor-121 | Size: 100 ug | CAT.#: RP1116-100 | Price: $484.00 | |
| Human Vascular Endothelial Growth Factor-121 (VEGF-121): Human Vascular Endothelial Growth Factor-121 | Size: 1000 ug | CAT.#: RP1116-1000 | Price: $4,090.00 | |
| Human VEGF-c ELISA Kit: Human Vascular Endothelial Growth Factor C ELISA Kit | Size: 96 Wells | CAT.#: CL0588 | Price: $581.00 | |
| Human VEGF-121, Animal-Free: Human Vascular Endothelial Growth Factor-121, Animal-Free | Size: 10 ug | CAT.#: RP1116AF-10 | Price: $213.00 | |
| Human VEGF-121, Animal-Free: Human Vascular Endothelial Growth Factor-121, Animal-Free | Size: 100 ug | CAT.#: RP1116AF-100 | Price: $533.00 | |
| Human VEGF-121, Animal-Free: Human Vascular Endothelial Growth Factor-121, Animal-Free | Size: 1000 ug | CAT.#: RP1116AF-1000 | Price: $4,499.00 |
Resources/Documents
Citations
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2017
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2016
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2014
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2013
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2012
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2011
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2010
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2009
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Gupta, A., C. Lobocki, S. Singh, M. Robertson, O.A. Akadiri, G. Malhotra, and I.T. Jackson. 2009. Actions and Comparative Efficacy of Phosphatidylcholine Formulation and Isolated Sodium Deoxycholate for Different Cell Types. Aesth Plast Surg. 33:346-352.
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Wu, J.C., A. Chruscinski, V.A. De Jesus Perez, H. Singh, M. Pitsiouni, M. Rabinovitch, P.J. Utz, and J.P. Cooke. 2009. Cholinergic modulation of angiogenesis: role of the 7 nicotinic acetylcholine receptor. Journal of cellular biochemistry. 108:433-446.
2008
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2007
Coman, T. Comprises nucleotide sequences associated with expression vector coding endothelial growth factor for use in diagnosis and treatment of tumor angiogenesis, inflammation, diabetic retinopathy, arthritis and psoriasis; wound healing agent. Patent US 7273751 B2.
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2006
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Hu, J., C. Rosen, and L. Cao. 2006. Polypeptide for use in the treatment of inflammation, rheumatoid arritis, psoriasis, and diabetic retinopathy. Patent US 7153942 B2.
Li, H., M. Adams, V. Calenda, and V. Fataccioli. 2006. Stimulating angiogenesis enhancing the repair of connective and support tissue, promoting the attachment, fixation and stabilization of tissue implants and enhancing wound healing. Patent US 7026299 B2.
2005
Hu, C. Rosen, and L. Cao. 2005. Administering anti-Flt4 antibody or an anti-VEGF-C antibody that inhibits binding between Flt4 ligand protein and Flt4 expressed in cells to treat breast cancer characterized by endothelial cells that express Flt4 tyrosine kinase. Patent Application US 20060025331 A1.
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2004
Hu, J., L. Cao, and A. Rosen. 20045. Nucleotide sequences coding polypeptide for use in the diagnosis, prevention and treatment of cancer, inflammation, diabetic retinopathy, rheumatoid arthritis and psoriasis. Patent US 6734285 B2.
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2003
Duan, D., and S. Rosen. 2003. Bone marrow specific protein. Patent Application US 20030191062 A1.
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Hu, J., L. Cao, and C. Rosen. 2003. Comprises nucleotide sequences coding mitogens for treating psoriasis, vision defects, tumors and arthritis. Patent Application US 20040143103 A1.
2001
Li, H., M. Adams, V. Calenda, and V. Fataccioli. 2001. Connective tissue growth factor-2. Patent Application US 20030012768 A1.
Coleman, T. 2001. Vascular endothelial growth factor-2. Patent Application US 20030215921 A1.
Hutley, L.J., A.C. Herington, W. Shurety, C. Cheung, D.A. Vesey, D.P. Cameron, and J.B. Prins. 2001. Human adipose tissue endothelial cells promote preadipocyte proliferation. American Journal of Physiology-Endocrinology And Metabolism. 281:E1037-E1044.
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1997
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1996
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1995
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