Instructions RAOSMC
5 Important Cell Culture Rules
MSDS Cryopreserved Cells
Cell Apps Flyer Smooth Muscle Cells
Cell Apps Flyer Cardiovascular Cells
Cell Apps Poster Primary Cells
Cell Applications Inc Brochure
Description
Rat Aortic Smooth Muscle Cells (RAOSMC) provide an excellent model system to study all aspects of cardiovascular function and disease, especially those related to mechanisms of hyperplasia and hypertrophy of intimal smooth muscle cells leading to vascular occlusion in atherosclerosis and stent restenosis.
RAOSMC from Cell Applications, Inc. have been utilized in dozens of research studies to:
- Provide a gold standard control for smooth muscle markers α-SMA, calponin and caldesmon expression
- Elucidate cytokines and growth factors signaling pathways implicated in the molecular regulation of smooth muscle cell proliferation, migration, and overall vascular function
- Demonstrate that peach extract inhibits intracellular Ca2+ and reactive oxygen species, showing promise to prevent cardiovascular diseases
- Investigate extracellular matrix properties and its role in cardiovascular health, repair of damaged vasculature and successful tissue engineering
- Demonstrate that hyperglycemia-induced elastin degradation products lead to vascular smooth muscle cell calcification
- Identify periostin, also implicated in mechanical stress and inflammation responses, as an early marker for SMC calcification
- Develop advanced stent technology, including novel surface materials, and drug delivery systems to prevent restenosis and other occlusive vasculopathies
Characterization: positive for smooth muscle cell specific alpha-actin expression
(Click to Enlarge) Rat Aortic Smooth Muscle Cells: RAOSMC (L), immunolabeled for smooth muscle-specific alpha-actin using the ABC method (R).
Details
Tissue | Normal healthy adult rat aorta |
QC | No bacteria, yeast, fungi, mycoplasma |
Character | Smooth muscle specific α-actin positive |
Bioassay | Attach, spread, proliferate in Growth Med |
Cryovial | 500,000 RAOSMC (2nd passage) frozen in Basal Medium w/ 10% FBS, 10% DMSO |
Kit | Cryovial frozen RAOSMC (R354-05a), Grwth Med (R311-500), Subcltr Rgnt Kit (090K) |
Proliferating | Shipped in Gr Med, 3rd psg (flasks or plates) |
Doublings | At least 16 |
Applications | Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use. |
Products
| Product | Size | CAT.# | Price | Quantity |
|---|---|---|---|---|
| Cryopreserved Rat Aortic Smooth Muscle Cells Total Kit, adult: 5x10^5 Cells (Adult), Medium & Subculture Reagents (See Details tab for specifics) | Size: 1 Kit | CAT.#: R354K-05a | Price: $655.00 | |
| Cryopreserved Rat Aortic Smooth Muscle Cells (RAOSMC), adult: Frozen RAOSMC (5x10^5) | Size: 1 Cryovial | CAT.#: R354-05a | Price: $475.00 | |
| Proliferating Rat Aortic Smooth Muscle Cells (RAOSMC), adult: Actively growing, dividing cells in medium | Size: 24 Well | CAT.#: R355-24Wa | Price: $665.00 | |
| Proliferating Rat Aortic Smooth Muscle Cells (RAOSMC), adult: Actively growing, dividing cells in medium | Size: T-75 Flask | CAT.#: R355-75a | Price: $665.00 | |
| Proliferating Rat Aortic Smooth Muscle Cells (RAOSMC), adult: Actively growing, dividing cells in medium | Size: T-25 Flask | CAT.#: R355-25a | Price: $475.00 | |
| Proliferating Rat Aortic Smooth Muscle Cells (RAOSMC), adult: Actively growing, dividing cells in medium | Size: 96 Well | CAT.#: R355-96Wa | Price: $785.00 |
Related Products
| Product | Size | CAT.# | Price | Quantity |
|---|---|---|---|---|
| Rat SMC Basal Medium: Basal medium (contains no growth supplement). Add GS before use. | Size: 500 ml | CAT.#: R310-500 | Price: $78.00 | |
| Rat SMC Growth Medium: All-in-one ready-to-use | Size: 500 ml | CAT.#: R311-500 | Price: $127.00 | |
| Rat SMC Growth Medium Kit: Basal medium & growth supplement sold together packaged separately | Size: Yields 500 ml | CAT.#: R311K-500 | Price: $136.00 | |
| Rat SMC Growth Supplement: Added to Basal Medium to create Growth Medium | Size: 50 ml | CAT.#: R311-GS | Price: $77.00 | |
| Rat SMC Induction Medium: Provides signals that change cell behavior | Size: 250 ml | CAT.#: R311I-250 | Price: $78.00 |
Extended Family Products
| Product | Size | CAT.# | Price | Quantity |
|---|---|---|---|---|
| Freezing Medium: For general cryopreservation of most primary cells. Contains FBS & DMSO. | Size: 50 ml | CAT.#: 040-50 | Price: $54.00 | |
| Cytofect Smooth Muscle Cell Transfection Kit (125 x 24-Wells): 125 x 24-Well | Size: 1 Kit | CAT.#: TF350K | Price: $328.00 | |
| Cytofect Smooth Muscle Cell Transfection Sample Kit (25 x 24-Wells): 25 x 24-Well Rxns | Size: 1 Sample Kit | CAT.#: TF350KS | Price: $62.00 | |
| Mouse Interleukin-6 (IL-6): Mouse Interleukin-6 | Size: 10 ug | CAT.#: RP2002-10 | Price: $194.00 | |
| Mouse Interleukin-6 (IL-6): Mouse Interleukin-6 | Size: 100 ug | CAT.#: RP2002-100 | Price: $624.00 | |
| Mouse Interleukin-6 (IL-6): Mouse Interleukin-6 | Size: 1000 ug | CAT.#: RP2002-1000 | Price: $5,327.00 | |
| Rat IL-6 ELISA Kit: Rat Interleukin-6 ELISA Kit | Size: 96 Wells | CAT.#: CL0412 | Price: $484.00 | |
| Rat Aortic Smooth Muscle Cell RNA (RAOSMC RNA), Adult : Total RNA Prepared from Rat Aortic Smooth Muscle Cells | Size: 25 ug | CAT.#: R354-R25a | Price: $796.00 | |
| Rat Aortic Smooth Muscle Cell RNA (RAOSMC RNA), Adult : Total RNA prepared from Rat Aortic Smooth Muscle Cells | Size: 10 ug | CAT.#: R354-R10a | Price: $398.00 | |
| Subculture Reagent Kit: 100 ml each of HBSS, Trypsin/EDTA & Trypsin Neutralizing Solution | Size: 1 Kit | CAT.#: 090K | Price: $63.00 |
Resources/Documents
Citations
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2017
Meyers, M., J. Rink, Q. Jiang, M. Kelly, J. Vercammen, C. Thaxton and M. Kibbe. 2017. Systemically administered collagen‐targeted gold nanoparticles bind to arterial injury following vascular interventions. Physiological Reports, 5:e13128.
2016
Cooper, K., I. Chun, D. Colter, S. Dhanaraj, A. Gosiewska, A. Seyda, C. Fang and C. Yang. 2016. Tissue engineered blood vessel. Patent US 9290742 B2.
Kopaliani, I., M. Martin, B. Zatschler, B. Müller and A. Deussen. 2016. Whey peptide Isoleucine-Tryptophan inhibits expression and activity of matrix metalloproteinase-2 in rat aorta. Peptides, 82:52-59.
Kopaliani, I. M. Martin, B. Zatschler, B. Müller and A. Deussen. 2016. Data of the natural and pharmaceutical angiotensin-converting enzyme inhibitors as a potent blockers of matrix metalloproteinase-2 expression in rat aorta. Data in Brief, doi:10.1016/j.dib.2016.06.059.
Li, Y., L. McRobb and L. Khachigian. 2016. Inhibition of intimal thickening after vascular injury with a cocktail of vascular endothelial growth factor and cyclic Arg-Gly-Asp peptide. Intl J Cardiol, 220:185-191.
Otto, S., A. Deussen, B. Zatschler, B. Muller, A. Neisser, K. Barth, H. Morawietz and I. Kopaliani. 2016. A novel role of endothelium in activation of latent pro-membrane type 1 MMP and pro-MMP-2 in rat aorta. Cardiovascular Research, 109:409-418.
Pugh, R., J. Slee, S. Farwell, Y. Li, T. Barthol, W. Patton and L. Lowe-Krentz. 2016. Transmembrane protein 184A is a receptor required for vascular smooth muscle cell responses to heparin. JBC, doi: 10.1074/jbc.M115.681122.
2015
Bhatta, A., L. Yao, H. Toque, A. Shatanawi, Z. Xu, R. Caldwell and R. Caldwell. 2015. Angiotensin II-Induced Arterial Thickening, Fibrosis and Stiffening Involves Elevated Arginase Function. PLoS ONE, 10(3): e0121727.
Chuang, T., W. Pearce and O. Khorram. 2015. miR-29c induction contributes to downregulation of vascular extracellular matrix proteins by glucocorticoids. Am J Physiol – Cell Physiol, 309:C117-C125.
Jiang, Y. 2015. The Expression of MRTF-A and AQP1 Play Important Roles in the Pathological Vascular Remodeling. Asian Pac J Cancer Prev 16:1375-1383.
Otto, S., A. Deussen, B. Zatschler, B. Müller, A. Neisser, K. Barth, H. Morawietz and I. Kopaliani. 2015. A Novel Role of Endothelium in Activation of Latent Pro-Membrane Type 1 Matrix Metalloproteinase and Pro-Matrix Metalloproteinase-2 in Rat Aorta. Cardiovascular Research, DOI: http://dx.doi.org/10.1093/cvr/cvv256.
Ueda, K., K. Yoshimura, O. Yamashita, T. Harada, N. Morikage, and K. Hamano. 2015. Possible Dual Role of Decorin in Abdominal Aortic Aneurysm. PLoS ONE 10: e0120689.
Zhu, S., M. Zhang, J. Davis, W. Wu, K. Surrao, H. Wang, and G. Wu. 2015. A single mutation in helix 8 enhances the angiotensin II type 1a receptor transport and signaling. Cellular Signalling, 27:2371-2379.
2014
Kopaliani, I. M. Martin, B. Zatschler, K. Bortlik, B. Müller, and A. Deussen. 2014. Cell-specific and endothelium-dependent regulations of matrix metalloproteinase-2 in rat aorta. Basic Research in Cardiology, June, 109:419.
Shi, F., X. Long, A. Hendershot, J. Miano and J. Sottile. 2014. Fibronectin Matrix Polymerization Regulates Smooth Muscle Cell Phenotype through a Rac1 Dependent Mechanism. PLoS ONE, doi.org/10.1371/journal.pone.0094988.
2013
Kono, R., Y. Okuno, M. Nakamura, K.-i. Inada, A. Tokuda, M. Yamashita, R. Hidaka, and H. Utsunomiya. 2013. Peach (Prunus persica) extract inhibits angiotensin II-induced signal transduction in vascular smooth muscle cells. Food chemistry. 139:371-376.
Li, Y., R. Bhindi, Z.J. Deng, S.W. Morton, P.T. Hammond, and L.M. Khachigian. 2013. Inhibition of vein graft stenosis with a c-jun targeting DNAzyme in a cationic liposomal formulation containing 1,2-dioleoyl-3-trimethylammonium propane (DOTAP)/1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE). International Journal of Cardiology. 168:3659-3664.
Shanmugam, I., A. Sinha, R. Norris, R. Markwald, and N. Vyavahare. 2013. Periostin as an early marker for elastin mediated vascular smooth muscle cell calcification. Cardiovascular System. 1.
Sinha, A., and N.R. Vyavahare. 2013. High-glucose levels and elastin degradation products accelerate osteogenesis in vascular smooth muscle cells. Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease. 10:410-419.
Yamashita, O., K. Yoshimura, A. Nagasawa, K. Ueda, N. Morikage, Y. Ikeda, and K. Hamano. 2013. Periostin Links Mechanical Strain to Inflammation in Abdominal Aortic Aneurysm. PloS one. 8:e79753.
Yamauchi, H., N. Motomura, U.-i. Chung, M. Sata, D. Takai, A. Saito, M. Ono, and S. Takamoto. 2013. Growth-associated hyperphosphatemia in young recipients accelerates aortic allograft calcification in a rat model. The Journal of Thoracic and Cardiovascular Surgery. 145:522-530.
2012
Chiu, W., J. Juang, S. Chang, C. Wu, C. Tsai, Y. Tseng and F. Chiang. 2012. Angiotensin II regulates the LARG/RhoA/MYPT1 axis in rat vascular smooth muscle in vitro. Acta Pharmacolog Sinica 33:1502-1510.
Ko, W.-c., B.-c. Chen, M.-j. Hsu, C.-t. Tsai, C.-y. Hong, and C.-h. Lin. 2012. Thrombin induced connective tissue growth factor expression in rat vascular smooth muscle cells via the PAR-1/JNK/AP-1 pathway. Acta pharmacologica Sinica. 33:49-56.
Malabanan, K.P., A.V. Sheahan, and L.M. Khachigian. 2012. Platelet-Derived Growth Factor-BB Mediates Cell Migration through Induction of Activating Transcription Factor 4 and Tenascin-C. The American journal of pathology. 180:2590-2597.
Midwinter, R., G. Maghzal, J. Dennis, B. Wu, H. Cai, A. Kapralov, N. Beloikova, Y. Tyurina, L. Dong, L. Khachigian, J. Neuzil, V. Kagan and R. Stocker. 2012. Succinobucol induces apoptosis in vascular smooth muscle cells. Free Rad Biol & Med, 52:871-879.
Minami, T., K. Kuwahara, Y. Nakagawa, M. Takaoka, H. Kinoshita, K. Nakao, Y. Kuwabara, Y. Yamada, C. Yamada, J. Shibata, S. Usami, S. Yasuno, T. Nishikimi, K. Ueshima, M. Sata, H. Nakano, T. Seno, Y. Kawahito, K. Sobue, A. Kimura, R. Nagai, and K. Nakao. 2012. Reciprocal expression of MRTF‐A and myocardin is crucial for pathological vascular remodelling in mice. EMBO J., 31:4428-4440.
Santiago, F.S. 2012. Regulatory Mechanisms in Vascular Injury and Repair. University of New South Wales, PhD dissertation.
2011
Ko, W. 2011. Connective Tissue Growth Factor and Cardiovascular Disease－Focusing on the Mechanisms of Structural Remodeling in Atrial Fibrillation and Atherothrombosis. Dissertation, Graduate Institute of Clinical Medicine, U0007-1801201207171100.
Taite, L.J., and J.L. West. 2011. Sustained delivery of nitric oxide from poly (ethylene glycol) hydrogels enhances endothelialization in a rat carotid balloon injury model. Cardiovascular Engineering and Technology. 2:113-123.
2010
Cheluvaraju, C. 2010. Characterization of anti-proteolytic and anti-proliferative activities of pentagalloylglucose; its potential application as a therapeutic agent in vascular diseases. Clemson University, PhD Dissertation.
Imamura, H., T. Ohta, K. Tsunetoshi, K. Doi, K. Nozaki, Y. Takagi, and K.-i. Kikuta. 2010. Transdifferentiation of bone marrow-derived endothelial progenitor cells into the smooth muscle cell lineage mediated by transforming growth factor-β1. Atherosclerosis. 211:114-121.
Ni, J., A. Waldman, and L. Khachigian. 2010. c-Jun Regulates Shear- and Injury-inducible Egr-1 Expression, Vein Graft Stenosis after Autologous End-to-Side Transplantation in Rabbits, and Intimal Hyperplasia in Human Saphenous Veins. JBC, 285:4038-4048.
Pappan, K. 2010. Hmg-coa secondary metabolites and uses thereof. Patent Application US 20120121554 A1.
2009
Adams, J.W., J. Ramirez, Y. Shi, W. Thomsen, J. Frazer, M. Morgan, J.E. Edwards, W. Chen, B.R. Teegarden, and Y. Xiong. 2009. APD791, 3-methoxy-n-(3-(1-methyl-1h-pyrazol-5-yl)-4-(2-morpholinoethoxy) phenyl) benzamide, a novel 5-hydroxytryptamine 2A receptor antagonist: pharmacological profile, pharmacokinetics, platelet activity and vascular biology. Journal of Pharmacology and Experimental Therapeutics. 331:96-103.
Alexis, J., N. Wang, W. Che, N. Lerner-Marmarosh, A. Sahni, V. Korshunov, Y. Zou, B. Ding, C. Yan, B. Berk, and J. Abe. 2009. Bcr Kinase Activation by Angiotensin II Inhibits Peroxisome Proliferator-Activated Receptor γ Transcriptional Activity in Vascular Smooth Muscle Cells. Circulation Research, 104:67-78.
Cooper, K., I. Chun, D., Colter, D., Dhanaraj, S., Gosiewska, A., Seyda, A. Fang, C. and Ynag, C. Tissue engineered blood vessels. Patent US 20090275129 A1.
Guha, S. 2009. The Role of GSK-3 in Notch Signalling in Vascular Smooth Muscle Cells. PhD Dissertation, Dublin City University.
Khachigian, L. 2009. Antiproliferative agents; administering protein; restenosis, atherosclerosis; cancer. Patent US 7541343 B2.
Kothapalli, C.R., and A. Ramamurthi. 2009. Copper nanoparticle cues for biomimetic cellular assembly of crosslinked elastin fibers. Acta Biomaterialia. 5:541-553.
Kothapalli, C.R., C.E. Gacchina, and A. Ramamurthi. 2009. Utility of hyaluronan oligomers and transforming growth factor-beta1 factors for elastic matrix regeneration by aneurysmal rat aortic smooth muscle cells. Tissue engineering. Part A. 15:3247-3260.
Kothapalli, C.R., P.M. Taylor, R.T. Smolenski, M.H. Yacoub, and A. Ramamurthi. 2009. Transforming growth factor beta 1 and hyaluronan oligomers synergistically enhance elastin matrix regeneration by vascular smooth muscle cells. Tissue engineering. Part A. 15:501-511.
Liu, M.Y., and L.M. Khachigian. 2009. HDAC-1 is Enriched at the PDGF-D Promoter in Response to IL-1beta and Forms a Cytokine-Inducible Gene Silencing Complex with NF-kappaB p65 and IRF-1. Journal of Biological Chemistry:10.1074/jbc.M1109.061903.
McSpadden, L.C., R.D. Kirkton, and N. Bursac. 2009. Electrotonic loading of anisotropic cardiac monolayers by unexcitable cells depends on connexin type and expression level. American Journal of Physiology-Cell Physiology. 297:C339-C351.
Morrow, D., J.P. Cullen, W. Liu, S. Guha, C. Sweeney, Y.A. Birney, N. Collins, D. Walls, E.M. Redmond, and P.A. Cahill. 2009. Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A. Arterioscler Thromb Vasc Biol. 29:1112-1118.
2008
Adams, J.W., J. Ramirez, D. Ortuno, Y. Shi, W. Thomsen, J.G. Richman, M. Morgan, P. Dosa, B.R. Teegarden, H. Al-Shamma, D.P. Behan, and D.T. Connolly. 2008. Anti-thrombotic and vascular effects of AR246686, a novel 5-HT2A receptor antagonist. European journal of pharmacology. 586:234-243.
Atkins, D., A. Baker, L. Khachigian. 2008. Catalytic molecules. Patent US 7355035 B1.
Frew, R., Y. Wang, T.M. Weiss, P. Nelson, and T.W. Sawyer. 2008. Attenuation of maitotoxin-induced cytotoxicity in rat aortic smooth muscle cells by inhibitors of Na+/Ca2+ exchange, and calpain activation. Toxicon. 51:1400-1408.
Malabanan, K.P. 2008. Roles of Activation Transcription Factor 4 (ATF4) and YrdC in the Response of Vascular Smooth Muscle Cells to Injury. In Centre for Vascular Research, School of Medical Sciences. University of New South Wales, Australia, PhD dissertation.
Poletek, P. 2008. Signalwege der C-Peptid-induzierten Proliferation glatter Gefäßmuskelzellen. Dissertation, Universität Ulm.
Shi, F., and J. Sottile. 2008. Caveolin-1-dependent beta1 integrin endocytosis is a critical regulator of fibronectin turnover. Journal of cell science. 121:2360-2371.
Taite, L.J., P. Yang, H.-W. Jun, and J.L. West. 2008. Nitric oxide-releasing polyurethane–PEG copolymer containing the YIGSR peptide promotes endothelialization with decreased platelet adhesion. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 84B:108-116.
2007
Csiszar, A., N. Labinskyy, K. Smith, A. Rivera, Z. Orosz, and Z. Ungvari. 2007. Vasculoprotective Effects of Anti-Tumor Necrosis Factor-α Treatment in Aging. Am J Pathol, 1770:388-398.
2006
Csiszar, A., M. Ahmad, K.E. Smith, N. Labinskyy, Q. Gao, G. Kaley, J.G. Edwards, M.S. Wolin, and Z. Ungvari. 2006. Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype. The American journal of pathology. 168:629-638.
Joddar, B., and A. Ramamurthi. 2006. Elastogenic effects of exogenous hyaluronan oligosaccharides on vascular smooth muscle cells. Biomaterials. 27:5698-5707.
Joddar, B., and A. Ramamurthi. 2006. Fragment size- and dose-specific effects of hyaluronan on matrix synthesis by vascular smooth muscle cells. Biomaterials. 27:2994-3004.
Liu, M.Y., M. Eyries, C. Zhang, F.S. Santiago, and L.M. Khachigian. 2006. Inducible platelet-derived growth factor D-chain expression by angiotensin II and hydrogen peroxide involves transcriptional regulation by Ets-1 and Sp1. Blood. 107:2322-2329.
Nakane, M., T. Kolasa, R. Chang, L. Miller, R. Moreland, and J. Brioni. 2006. Acrylamide Analog as a Novel Nitric Oxide-Independent Soluble Guanylyl Cyclase Activator. J Pharmacol Sci, 102:231-238.
Ross, J.J., Z. Hong, B. Willenbring, L. Zeng, B. Isenberg, E.H. Lee, M. Reyes, S.A. Keirstead, E.K. Weir, and R.T. Tranquillo. 2006. Cytokine-induced differentiation of multipotent adult progenitor cells into functional smooth muscle cells. Journal of Clinical Investigation. 116:3139-3149.
Taite, L.J., and J.L. West. 2006. Poly(ethylene glycol)-lysine dendrimers for targeted delivery of nitric oxide. Journal of Biomaterials Science, Polymer Edition. 17:1159-1172.
West, S., E. Ogru, and R. Gianello. 2006. Compounds having anti-cancer properties. Patent Application US 20090233881 A1.
2005
Campagnolo, L., A. Leahy, S. Chitnis, S. Koschnick, M. Fitch, J. Fallon, D. Loskutoff, M. Taubman, and H. Stuhlmann. 2005. EGFL7 Is a Chemoattractant for Endothelial Cells and Is Up-Regulated in Angiogenesis and Arterial Injury. Am J Pathol, 167:275-284.
Morrow, D., C. Sweeney, Y.A. Birney, P.M. Cummins, D. Walls, E.M. Redmond, and P.A. Cahill. 2005. Cyclic strain inhibits Notch receptor signaling in vascular smooth muscle cells in vitro. Circulation research. 96:567-575.
Pintucci, G., P.-J. Yu, F. Saponara, D.L. Kadian-Dodov, A.C. Galloway, and P. Mignatti. 2005. PDGF-BB induces vascular smooth muscle cell expression of high molecular weight FGF-2, which accumulates in the nucleus. Journal of cellular biochemistry. 95:1292-1300.
Sato, Y., R. Nakamura, M. Satoh, K. Fujishita, S. Mori, S. Ishida, T. Yamaguchi, K. Inoue, T. Nagao, and Y. Ohno. 2005. Thyroid Hormone Targets Matrix Gla Protein Gene Associated With Vascular Smooth Muscle Calcification. Circulation research. 97:550-557.
Sottile, J., and J. Chandler. 2005. Fibronectin Matrix Turnover Occurs through a Caveolin-1–dependent Process. Molecular biology of the cell. 16:757-768.
2004
Deng, Y.-M., B.J. Wu, P.K. Witting, and R. Stocker. 2004. Probucol Protects Against Smooth Muscle Cell Proliferation by Upregulating Heme Oxygenase-1. Circulation. 110:1855-1860.
Santiago, F.S., and L.M. Khachigian. 2004. Ets-1 stimulates platelet-derived growth factor A-chain gene transcription and vascular smooth muscle cell growth via cooperative interactions with Sp1. Circulation research. 95:479-487.
West, S. and Ogru, E. 2004. Compounds having anti-proliferative properties. Patent Application US 20060241085 A1.
2002
Khachigian, L. 2002. Treatment of cancer. Patent Application US 20030203864 A1.
Khan, K.F., D.J. Falcone, and R. Kraemer. 2002. Nerve growth factor activation of Erk-1 and Erk-2 induces matrix metalloproteinase-9 expression in vascular smooth muscle cells. Journal of Biological Chemistry. 277:2353-2359.
2001
Andrade-Gordon, P., C.K. Derian, B.E. Maryanoff, H.-C. Zhang, M.F. Addo, W.-m. Cheung, B.P. Damiano, M.R. D'Andrea, A.L. Darrow, and L. de Garavilla. 2001. Administration of a potent antagonist of protease-activated receptor-1 (PAR-1) attenuates vascular restenosis following balloon angioplasty in rats. Journal of Pharmacology and Experimental Therapeutics. 298:34-42.
Santiago, F.S., H.C. Lowe, Y.V. Bobryshev, and L.M. Khachigian. 2001. Induction of the Transcriptional Repressor Yin Yang-1 by Vascular Cell Injury: AUTOCRINE/PARACRINE ROLE OF ENDOGENOUS FIBROBLAST GROWTH FACTOR-2. Journal of Biological Chemistry. 276:41143-41149.
1999
Andrade-Gordon, P., B.E. Maryanoff, C.K. Derian, H.-C. Zhang, M.F. Addo, A.L. Darrow, A.J. Eckardt, W.J. Hoekstra, D.F. McComsey, D. Oksenberg, E.E. Reynolds, R.J. Santulli, R.M. Scarborough, C.E. Smith, and K.B. White. 1999. Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor. Proceedings of the National Academy of Sciences. 96:12257-12262.
Day, F., L. Rafty, C. Chesterman, and L. Khachigian. 1999. Angiotensin II (ATII)-inducible Platelet-derived Growth Factor A-chain Gene Expression Is p42/44 Extracellular Signal-regulated Kinase-1/2 and Egr-1-dependent and Mediated via the ATII Type 1 but Not Type 2 Receptor. J Biol Chem, 274:23726-23733.
Santiago, F., D. Atkins, and nL. Khachigian. 1999. Vascular Smooth Muscle Cell Proliferation and Regrowth after Mechanical Injury in Vitro Are. Egr-1/NGFI-A-Dependent. Am J Pathol, 155:897-905.