5 Important Cell Culture Rules
MSDS Cryopreserved Cells
Cell Apps Flyer Smooth Muscle Cells
Cell Apps Flyer Cardiovascular Cells
Cell Apps Poster Primary Cells
Cell Applications Inc Brochure
Rat Aortic Smooth Muscle Cells (RAOSMC) provide an excellent model system to study all aspects of cardiovascular function and disease, especially those related to mechanisms of hyperplasia and hypertrophy of intimal smooth muscle cells leading to vascular occlusion in atherosclerosis and stent restenosis.
RAOSMC from Cell Applications, Inc. have been utilized in dozens of research studies to:
- Provide a gold standard control for smooth muscle markers α-SMA, calponin and caldesmon expression
- Elucidate cytokines and growth factors signaling pathways implicated in the molecular regulation of smooth muscle cell proliferation, migration, and overall vascular function
- Demonstrate that peach extract inhibits intracellular Ca2+ and reactive oxygen species, showing promise to prevent cardiovascular diseases
- Investigate extracellular matrix properties and its role in cardiovascular health, repair of damaged vasculature and successful tissue engineering
- Demonstrate that hyperglycemia-induced elastin degradation products lead to vascular smooth muscle cell calcification
- Identify periostin, also implicated in mechanical stress and inflammation responses, as an early marker for SMC calcification
- Develop advanced stent technology, including novel surface materials, and drug delivery systems to prevent restenosis and other occlusive vasculopathies
Characterization: positive for smooth muscle cell specific alpha-actin expression
Normal healthy adult rat aorta
No bacteria, yeast, fungi, mycoplasma
Smooth muscle specific α-actin positive
|Attach, spread, proliferate in Growth Med|
500,000 RAOSMC (2nd passage) frozen in Basal Medium w/ 10% FBS, 10% DMSO
Cryovial frozen RAOSMC (R354-05a), Grwth Med (R311-500), Subcltr Rgnt Kit (090K)
Shipped in Gr Med, 3rd psg (flasks or plates)
At least 16
Laboratory research use only (RUO). Not for human, clinical, diagnostic or veterinary use.
|Cryopreserved RAOSMC, Adult: 5x10^5 Cells (Adult), Medium & Subculture Reagents (See Details tab for specifics)||Size: 1 Kit||CAT.#: R354K-05a||Price: $635.00|
|Cryopreserved RAOSMC, Adult: Frozen RAOSMC (5x10^5)||Size: 1 Cryovial||CAT.#: R354-05a||Price: $475.00|
|Proliferating RAOSMC, Adult: Actively growing, dividing cells in medium||Size: T-25 Flask||CAT.#: R355-25a||Price: $475.00|
|Proliferating RAOSMC, Adult: Actively growing, dividing cells in medium||Size: 96 Well||CAT.#: R355-96Wa||Price: $785.00|
|Proliferating RAOSMC, Adult: Actively growing, dividing cells in medium||Size: 6 Well||CAT.#: R355-6Wa||Price: $665.00|
|Proliferating RAOSMC, Adult: Actively growing, dividing cells in medium||Size: T-75 Flask||CAT.#: R355-75a||Price: $665.00|
|Rat SMC Basal Medium: Basal medium (contains no growth supplement). Add GS before use.||Size: 500 ml||CAT.#: R310-500||Price: $60.00|
|Rat SMC Growth Medium: All-in-one ready-to-use||Size: 500 ml||CAT.#: R311-500||Price: $110.00|
|Rat SMC Growth Medium Kit: Basal medium & growth supplement sold together packaged separately||Size: Yields 500 ml||CAT.#: R311K-500||Price: $118.00|
|Rat SMC Growth Supplement: Added to Basal Medium to create Growth Medium||Size: 50 ml||CAT.#: R311-GS||Price: $59.00|
|Rat SMC Induction Medium: Provides signals that change cell behavior||Size: 250 ml||CAT.#: R311I-250||Price: $68.00|
Extended Family Products
|Cyto-X Cell Counting Reagent: 500 tests||Size: 1 Bottle||CAT.#: 028-01||Price: $139.00|
|Cyto-X Cell Counting Reagent Sample: 100 tests||Size: Sample||CAT.#: 028-S||Price: $36.00|
|Cytofect™ Smooth Muscle Cell Transfection Kit: 125 x 24-Well||Size: 1 Kit||CAT.#: TF350K||Price: $285.00|
|Cytofect™ Smooth Muscle Cell Transfection Kit: 25 x 24-Well Rxns||Size: 1 Sample Kit||CAT.#: TF350KS||Price: $54.00|
|Freezing Medium: For general cryopreservation of most primary cells. Contains FBS & DMSO.||Size: 50 ml||CAT.#: 040-50||Price: $54.00|
|Mouse Interleukin-6 (IL-6): Mouse Interleukin-6||Size: 10 ug||CAT.#: RP2002-10||Price: $194.00|
|Mouse Interleukin-6 (IL-6): Mouse Interleukin-6||Size: 100 ug||CAT.#: RP2002-100||Price: $624.00|
|Mouse Interleukin-6 (IL-6): Mouse Interleukin-6||Size: 1000 ug||CAT.#: RP2002-1000||Price: $5,327.00|
|RAOSMC RNA, Adult : Total RNA prepared from Rat Aortic Smooth Muscle Cells||Size: 10 ug||CAT.#: R354-R10a||Price: $350.00|
|RAOSMC RNA, Adult : Total RNA Prepared from Rat Aortic Smooth Muscle Cells||Size: 25 ug||CAT.#: R354-R25a||Price: $700.00|
|Rat IL-6 ELISA Kit: Rat Interleukin-6 ELISA Kit||Size: 96 Wells||CAT.#: CL0412||Price: $484.00|
|Subculture Reagent Kit: 100 ml each of HBSS, Trypsin/EDTA & Trypsin Neutralizing Solution||Size: 1 Kit||CAT.#: 090K||Price: $55.00|
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Shi, F., X. Long, A. Hendershot, J. Miano and J. Sottile. 2014. Fibronectin Matrix Polymerization Regulates Smooth Muscle Cell Phenotype through a Rac1 Dependent Mechanism. PLoS ONE, doi.org/10.1371/journal.pone.0094988.
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Yamashita, O., K. Yoshimura, A. Nagasawa, K. Ueda, N. Morikage, Y. Ikeda, and K. Hamano. 2013. Periostin Links Mechanical Strain to Inflammation in Abdominal Aortic Aneurysm. PloS one. 8:e79753.
Yamauchi, H., N. Motomura, U.-i. Chung, M. Sata, D. Takai, A. Saito, M. Ono, and S. Takamoto. 2013. Growth-associated hyperphosphatemia in young recipients accelerates aortic allograft calcification in a rat model. The Journal of Thoracic and Cardiovascular Surgery. 145:522-530.
Chiu, W., J. Juang, S. Chang, C. Wu, C. Tsai, Y. Tseng and F. Chiang. 2012. Angiotensin II regulates the LARG/RhoA/MYPT1 axis in rat vascular smooth muscle in vitro. Acta Pharmacolog Sinica 33:1502-1510.
Ko, W.-c., B.-c. Chen, M.-j. Hsu, C.-t. Tsai, C.-y. Hong, and C.-h. Lin. 2012. Thrombin induced connective tissue growth factor expression in rat vascular smooth muscle cells via the PAR-1/JNK/AP-1 pathway. Acta pharmacologica Sinica. 33:49-56.
Malabanan, K.P., A.V. Sheahan, and L.M. Khachigian. 2012. Platelet-Derived Growth Factor-BB Mediates Cell Migration through Induction of Activating Transcription Factor 4 and Tenascin-C. The American journal of pathology. 180:2590-2597.
Midwinter, R., G. Maghzal, J. Dennis, B. Wu, H. Cai, A. Kapralov, N. Beloikova, Y. Tyurina, L. Dong, L. Khachigian, J. Neuzil, V. Kagan and R. Stocker. 2012. Succinobucol induces apoptosis in vascular smooth muscle cells. Free Rad Biol & Med, 52:871-879.
Minami, T., K. Kuwahara, Y. Nakagawa, M. Takaoka, H. Kinoshita, K. Nakao, Y. Kuwabara, Y. Yamada, C. Yamada, J. Shibata, S. Usami, S. Yasuno, T. Nishikimi, K. Ueshima, M. Sata, H. Nakano, T. Seno, Y. Kawahito, K. Sobue, A. Kimura, R. Nagai, and K. Nakao. 2012. Reciprocal expression of MRTF‐A and myocardin is crucial for pathological vascular remodelling in mice. EMBO J., 31:4428-4440.
Santiago, F.S. 2012. Regulatory Mechanisms in Vascular Injury and Repair. University of New South Wales, PhD dissertation.
Ko, W. 2011. Connective Tissue Growth Factor and Cardiovascular Disease－Focusing on the Mechanisms of Structural Remodeling in Atrial Fibrillation and Atherothrombosis. Dissertation, Graduate Institute of Clinical Medicine, U0007-1801201207171100.
Taite, L.J., and J.L. West. 2011. Sustained delivery of nitric oxide from poly (ethylene glycol) hydrogels enhances endothelialization in a rat carotid balloon injury model. Cardiovascular Engineering and Technology. 2:113-123.
Cheluvaraju, C. 2010. Characterization of anti-proteolytic and anti-proliferative activities of pentagalloylglucose; its potential application as a therapeutic agent in vascular diseases. Clemson University, PhD Dissertation.
Imamura, H., T. Ohta, K. Tsunetoshi, K. Doi, K. Nozaki, Y. Takagi, and K.-i. Kikuta. 2010. Transdifferentiation of bone marrow-derived endothelial progenitor cells into the smooth muscle cell lineage mediated by transforming growth factor-β1. Atherosclerosis. 211:114-121.
Ni, J., A. Waldman, and L. Khachigian. 2010. c-Jun Regulates Shear- and Injury-inducible Egr-1 Expression, Vein Graft Stenosis after Autologous End-to-Side Transplantation in Rabbits, and Intimal Hyperplasia in Human Saphenous Veins. JBC, 285:4038-4048.
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Alexis, J., N. Wang, W. Che, N. Lerner-Marmarosh, A. Sahni, V. Korshunov, Y. Zou, B. Ding, C. Yan, B. Berk, and J. Abe. 2009. Bcr Kinase Activation by Angiotensin II Inhibits Peroxisome Proliferator-Activated Receptor γ Transcriptional Activity in Vascular Smooth Muscle Cells. Circulation Research, 104:67-78.
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Guha, S. 2009. The Role of GSK-3 in Notch Signalling in Vascular Smooth Muscle Cells. PhD Dissertation, Dublin City University.
Khachigian, L. 2009. Antiproliferative agents; administering protein; restenosis, atherosclerosis; cancer. Patent US 7541343 B2.
Kothapalli, C.R., and A. Ramamurthi. 2009. Copper nanoparticle cues for biomimetic cellular assembly of crosslinked elastin fibers. Acta Biomaterialia. 5:541-553.
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Liu, M.Y., and L.M. Khachigian. 2009. HDAC-1 is Enriched at the PDGF-D Promoter in Response to IL-1beta and Forms a Cytokine-Inducible Gene Silencing Complex with NF-kappaB p65 and IRF-1. Journal of Biological Chemistry:10.1074/jbc.M1109.061903.
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Atkins, D., A. Baker, L. Khachigian. 2008. Catalytic molecules. Patent US 7355035 B1.
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Nakane, M., T. Kolasa, R. Chang, L. Miller, R. Moreland, and J. Brioni. 2006. Acrylamide Analog as a Novel Nitric Oxide-Independent Soluble Guanylyl Cyclase Activator. J Pharmacol Sci, 102:231-238.
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Taite, L.J., and J.L. West. 2006. Poly(ethylene glycol)-lysine dendrimers for targeted delivery of nitric oxide. Journal of Biomaterials Science, Polymer Edition. 17:1159-1172.
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Campagnolo, L., A. Leahy, S. Chitnis, S. Koschnick, M. Fitch, J. Fallon, D. Loskutoff, M. Taubman, and H. Stuhlmann. 2005. EGFL7 Is a Chemoattractant for Endothelial Cells and Is Up-Regulated in Angiogenesis and Arterial Injury. Am J Pathol, 167:275-284.
Morrow, D., C. Sweeney, Y.A. Birney, P.M. Cummins, D. Walls, E.M. Redmond, and P.A. Cahill. 2005. Cyclic strain inhibits Notch receptor signaling in vascular smooth muscle cells in vitro. Circulation research. 96:567-575.
Pintucci, G., P.-J. Yu, F. Saponara, D.L. Kadian-Dodov, A.C. Galloway, and P. Mignatti. 2005. PDGF-BB induces vascular smooth muscle cell expression of high molecular weight FGF-2, which accumulates in the nucleus. Journal of cellular biochemistry. 95:1292-1300.
Sato, Y., R. Nakamura, M. Satoh, K. Fujishita, S. Mori, S. Ishida, T. Yamaguchi, K. Inoue, T. Nagao, and Y. Ohno. 2005. Thyroid Hormone Targets Matrix Gla Protein Gene Associated With Vascular Smooth Muscle Calcification. Circulation research. 97:550-557.
Sottile, J., and J. Chandler. 2005. Fibronectin Matrix Turnover Occurs through a Caveolin-1–dependent Process. Molecular biology of the cell. 16:757-768.
Deng, Y.-M., B.J. Wu, P.K. Witting, and R. Stocker. 2004. Probucol Protects Against Smooth Muscle Cell Proliferation by Upregulating Heme Oxygenase-1. Circulation. 110:1855-1860.
Santiago, F.S., and L.M. Khachigian. 2004. Ets-1 stimulates platelet-derived growth factor A-chain gene transcription and vascular smooth muscle cell growth via cooperative interactions with Sp1. Circulation research. 95:479-487.
West, S. and Ogru, E. 2004. Compounds having anti-proliferative properties. Patent Application US 20060241085 A1.
Khachigian, L. 2002. Treatment of cancer. Patent Application US 20030203864 A1.
Khan, K.F., D.J. Falcone, and R. Kraemer. 2002. Nerve growth factor activation of Erk-1 and Erk-2 induces matrix metalloproteinase-9 expression in vascular smooth muscle cells. Journal of Biological Chemistry. 277:2353-2359.
Andrade-Gordon, P., C.K. Derian, B.E. Maryanoff, H.-C. Zhang, M.F. Addo, W.-m. Cheung, B.P. Damiano, M.R. D'Andrea, A.L. Darrow, and L. de Garavilla. 2001. Administration of a potent antagonist of protease-activated receptor-1 (PAR-1) attenuates vascular restenosis following balloon angioplasty in rats. Journal of Pharmacology and Experimental Therapeutics. 298:34-42.
Santiago, F.S., H.C. Lowe, Y.V. Bobryshev, and L.M. Khachigian. 2001. Induction of the Transcriptional Repressor Yin Yang-1 by Vascular Cell Injury: AUTOCRINE/PARACRINE ROLE OF ENDOGENOUS FIBROBLAST GROWTH FACTOR-2. Journal of Biological Chemistry. 276:41143-41149.
Andrade-Gordon, P., B.E. Maryanoff, C.K. Derian, H.-C. Zhang, M.F. Addo, A.L. Darrow, A.J. Eckardt, W.J. Hoekstra, D.F. McComsey, D. Oksenberg, E.E. Reynolds, R.J. Santulli, R.M. Scarborough, C.E. Smith, and K.B. White. 1999. Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor. Proceedings of the National Academy of Sciences. 96:12257-12262.
Day, F., L. Rafty, C. Chesterman, and L. Khachigian. 1999. Angiotensin II (ATII)-inducible Platelet-derived Growth Factor A-chain Gene Expression Is p42/44 Extracellular Signal-regulated Kinase-1/2 and Egr-1-dependent and Mediated via the ATII Type 1 but Not Type 2 Receptor. J Biol Chem, 274:23726-23733.
Santiago, F., D. Atkins, and nL. Khachigian. 1999. Vascular Smooth Muscle Cell Proliferation and Regrowth after Mechanical Injury in Vitro Are. Egr-1/NGFI-A-Dependent. Am J Pathol, 155:897-905.